2-FLUORO-5-METHOXYBENZOIC ACID

Product Name: 2-FLUORO-5-METHOXYBENZOIC ACID
CAS No.: 367-83-9
Chemical Name: 2-FLUORO-5-METHOXYBENZOIC ACID
Synonyms: BUTTPARK 45\01-62;RARECHEM AL BO 0748;2-Fluoro-5-methoxybenzoicaci;2-FLUORO-5-METHOXYBENZOIC ACID;6-Fluoro-3-methoxybenzoic acid;Benzoic acid, 2-fluoro-5-methoxy-;2-Fluoro-5-(methyloxy)benzoic acid;2-Fluoro-5-Methoxybenzoic acid, 97+%;3-Carboxy-4-fluoroanisole, 6-Fluoro-m-anisic acid
CBNumber: CB7141401
Molecular Formula: C8H7FO3
Formula Weight: 170.14
MOL File: 367-83-9.mol

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2-FLUORO-5-METHOXYBENZOIC ACID Property

Melting point:: 146-150
Boiling point:: 302.7±22.0 °C(Predicted)
Density: 1.307
storage temp.: Sealed in dry,Room Temperature
pka: 3.15±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 367-83-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36
Hazard Note: Irritant
HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: F599343
Product name: 2-Fluoro-5-methoxybenzoicAcid
Packaging: 5g
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2621-3-25
Product name: 2-Fluoro-5-methoxybenzoic acid
Purity: 97%
Packaging: 1g
Price: $20
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2621-3-25
Product name: 2-Fluoro-5-methoxybenzoic acid
Purity: 97%
Packaging: 5G
Price: $40
Updated: 2021/12/16

Apolloscientific

Product number: PC8208
Product name: 2-Fluoro-5-methoxybenzoicacid
Packaging: 250mg
Price: $44
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2621-3-25
Product name: 2-Fluoro-5-methoxybenzoic acid
Purity: 97%
Packaging: 25g
Price: $75
Updated: 2021/12/16

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2-FLUORO-5-METHOXYBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

Class white powder

Uses

2-Fluoro-5-methoxybenzoic acid is used as an organic chemical synthesis intermediate.

Synthesis

459-60-9

124-38-9

367-83-9

The general procedure for the synthesis of 2-fluoro-5-methoxybenzoic acid from 4-fluoroanisole and carbon dioxide was as follows: 1-fluoro-4-methoxybenzene (5 g, 39.6 mmol, 1.0 eq.) and PMDTA (7.56 g, 43.62 mmol, 1.1 eq.) were dissolved in anhydrous THF (100 mL) under nitrogen protection and cooled to -60 °C. A solution of s-BuLi (1.3 M, 36.6 mL, 47.5 mmol, 1.2 eq.) was added slowly over 1 hr. The reaction mixture continued to be stirred at -60 °C for 2 hours. Subsequently, carbon dioxide gas was passed into the solution for 1 hour. After completion of the reaction, the mixture was slowly warmed to room temperature, acidified with 1 M HCl solution and extracted with EtOAc. The organic phases were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: EtOAc/petroleum ether, gradient from 0:1 to 1:1) to afford 2-fluoro-5-methoxybenzoic acid as a yellow solid (5.4 g, 80% yield).LC-MS: m/z 171.1 [M+H]+, 193.0 [M+Na]+. 1H NMR (400 MHz, DMSO-d6) δ. 13.33 (s, 1H), 7.31 (m, 1H), 7.24 (m, 1H), 7.20-7.16 (m, 1H), 3.78 (s, 3H).

References

[1] Journal of Organic Chemistry, 2007, vol. 72, # 4, p. 1271 - 1275
[2] Patent: WO2013/37705, 2013, A2. Location in patent: Page/Page column 61; 62
[3] Patent: WO2004/14856, 2004, A1. Location in patent: Page 21
[4] Tetrahedron Letters, 1992, vol. 33, # 49, p. 7495 - 7498

2-FLUORO-5-METHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

4-Fluoroanisole Carbon dioxide Tetrahydrofuran Diethyl ether Sodium hydroxide n-Butyllithium Citric acid

Preparation Products

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2-FLUORO-5-METHOXYBENZOIC ACID Suppliers

China 95 France 1 Germany 2 India 3 Italy 1 United Kingdom 8 United States 14 Global 124

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View Lastest Price from 2-FLUORO-5-METHOXYBENZOIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-FLUORO-5-METHOXYBENZOIC ACID 367-83-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 2-FLUORO-5-METHOXYBENZOIC ACID 367-83-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

367-83-9, 2-FLUORO-5-METHOXYBENZOIC ACIDRelated Search:

2-FLUORO-5-METHOXYBENZOIC ACID

BUTTPARK 45\01-62

RARECHEM AL BO 0748

3-Carboxy-4-fluoroanisole, 6-Fluoro-m-anisic acid

2-Fluoro-5-(methyloxy)benzoic acid

6-Fluoro-3-methoxybenzoic acid

2-Fluoro-5-Methoxybenzoic acid, 97+%

Benzoic acid, 2-fluoro-5-methoxy-

2-Fluoro-5-methoxybenzoicaci

367-83-9

Fluorine series

Benzoic acid

Acids & Esters

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds