5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID
- Product Name
- 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID
- CAS No.
- 10406-06-1
- Chemical Name
- 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID
- Synonyms
- RARECHEM AL BE 0374;5-BroMo-3-indolecarboxylic Acid;5-BROMOINDOLE-3-CARBOXYLIC ACID;5-Bromoindole-3-carboxylicAcid>5-Bromoindole-3-carboxylicacid,97%;5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylic acid, 5-broMo-
- CBNumber
- CB7142938
- Molecular Formula
- C9H6BrNO2
- Formula Weight
- 240.05
- MOL File
- 10406-06-1.mol
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID Property
- Melting point:
- 238-240 °C (decomp)
- Boiling point:
- 240°C(lit.)
- Density
- 1.838±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3.68±0.30(Predicted)
- form
- Solid
- color
- White to Light yellow
- InChI
- InChI=1S/C9H6BrNO2/c10-5-1-2-8-6(3-5)7(4-11-8)9(12)13/h1-4,11H,(H,12,13)
- InChIKey
- JVZMBSGNSAHFCY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(Br)C=C2)C(C(O)=O)=C1
- CAS DataBase Reference
- 10406-06-1(CAS DataBase Reference)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B4790
- Product name
- 5-Bromoindole-3-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $126
- Updated
- 2025/07/31
- Product number
- B4790
- Product name
- 5-Bromoindole-3-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $504
- Updated
- 2025/07/31
- Product number
- B694523
- Product name
- 5-Bromo-1H-indole-3-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB33252
- Product name
- 5-Bromo-1H-indole-3-carboxylic acid
- Packaging
- 100mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 072991
- Product name
- 5-Bromo-1H-indole-3-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
5-Bromo-1H-indole-3-carboxylic Acid is a useful intermediate used in the synthesis of indole derivatives that functions as inhibitors for the vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase.
Synthesis
10075-50-0
124-38-9
10406-06-1
Lithium tert-butoxide (LiOtBu, 160 mg, 2.00 mmol) and 5-bromoindole (23.4 mg, 0.4 mmol) were added to a dry two-neck flask. The reaction vessel was evacuated and filled with carbon dioxide gas. Subsequently, N,N-dimethylformamide (DMF, 2 mL) was added and the mixture was stirred and reacted at 100 °C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature, the reaction was carefully quenched with 2N hydrochloric acid solution and extracted with ethyl acetate (5 x 5 mL). The organic phases were combined, washed sequentially with water (2 x 5 mL) and saturated saline (1 x 5 mL) and dried over anhydrous magnesium sulfate. The dried organic phases were concentrated under reduced pressure and the residue was purified by preparative thin layer chromatography (Spreader: hexane/acetone=1:1, v/v) to afford the target compound 5-bromo-1H-indole-3-carboxylic acid (153.0 mg, 95% yield) as a white solid.
References
[1] Organic Letters, 2012, vol. 14, # 20, p. 5326 - 5329,4
[2] Heterocycles, 2015, vol. 90, # 2, p. 1196 - 1204
5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
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View Lastest Price from 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID manufacturers
- Product
- 5-BROMO-1H-INDOLE-3-CARBOXYLIC ACID 10406-06-1
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25