4-NITRO-PYRIDIN-2-YLAMINE
- Product Name
- 4-NITRO-PYRIDIN-2-YLAMINE
- CAS No.
- 4487-50-7
- Chemical Name
- 4-NITRO-PYRIDIN-2-YLAMINE
- Synonyms
- 4-NITROPYRIDIN-2-AMINE;4-NITRO-2-PYRIDINAMINE;2-AMINO-4-NITROPYRIDINE;2-PyridinaMine, 4-nitro-;4-NITRO-PYRIDIN-2-YLAMINE;2-Amino-4-nitropyridine97%;2-AMINO-4-NITROPYRIDINE 97%;2-Pyridinamine,4-nitro-(9CI);4-NITRO-PYRIDIN-2-YLAMINE ISO 9001：2015 REACH
- CBNumber
- CB7145661
- Molecular Formula
- C5H5N3O2
- Formula Weight
- 139.11
- MOL File
- 4487-50-7.mol
4-NITRO-PYRIDIN-2-YLAMINE Property
- Melting point:
- 96 °C
- Boiling point:
- 339.0±22.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 3.43±0.11(Predicted)
- color
- Light yellow to orange
- CAS DataBase Reference
- 4487-50-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N519915
- Product name
- 4-Nitropyridin-2-amine
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-W019623
- Product name
- 2-Amino-4-nitropyridine
- Purity
- 99.81%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- OR13602
- Product name
- 2-Amino-4-nitropyridine
- Packaging
- 250mg
- Price
- $47
- Updated
- 2021/12/16
- Product number
- R734
- Product name
- 2-Amino-4-nitropyridine
- Packaging
- 5g
- Price
- $451
- Updated
- 2021/12/16
- Product number
- CS-W019623
- Product name
- 2-Amino-4-nitropyridine
- Purity
- 99.81%
- Packaging
- 10g
- Price
- $530
- Updated
- 2021/12/16
4-NITRO-PYRIDIN-2-YLAMINE Chemical Properties,Usage,Production
Uses
4-Nitropyridin-2-amine is used to synthesize tetrahydronaphthalene Raf inhibitors.
Synthesis
942076-74-6
4487-50-7
Step 3: Synthesis of 4-nitropyridine-2-amino intermediate-22 N-(4-methoxybenzyl)-4-nitropyridin-2-amine (Int-21, 27.8 g, 0.11 mol) and anisole (13 mL, 0.12 mol) were dissolved in trifluoroacetic acid (112 mL) and the reaction was heated at 80 °C for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated. The resulting residue was ground with EtOAc and hexane to give a pale yellow solid, which was separated by filtration. The filtrate was allowed to stand overnight to precipitate a second batch of crystals. The two solid batches were combined, dissolved in 1N NaOH solution (250 mL) and extracted with EtOAc (2 x 250 mL). The organic phases were combined, dried over magnesium sulfate, filtered and concentrated to give 4-nitropyridin-2-amine as an orange solid (10.2 g, 67% yield). LCMS (FA) ES+: m/z 140. 1H NMR (400 MHz, CD3OD) δ ppm: 8.15 (dd, J = 5.7, 0.6 Hz, 1H), 7.23 (dd, J = 2.0, 0.6 Hz, 1H), 7.20 (dd, J = 5.7, 2.0 Hz, 1H).
References
[1] Patent: WO2011/146591, 2011, A1. Location in patent: Page/Page column 72-73
[2] Patent: US2012/15942, 2012, A1. Location in patent: Page/Page column 51
[3] Patent: EP3305788, 2018, A1. Location in patent: Paragraph 0059; 0062
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 6, p. 1836 - 1846
4-NITRO-PYRIDIN-2-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-NITRO-PYRIDIN-2-YLAMINE manufacturers
- Product
- 4-NITRO-PYRIDIN-2-YLAMINE 4487-50-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-08
- Product
- 4-NITRO-PYRIDIN-2-YLAMINE 4487-50-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99.99%
- Supply Ability
- 1kg-10MT
- Release date
- 2019-05-24