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ChemicalBook > CAS DataBase List > 2-Chloro-5-nitropyridin-4-amine

2-Chloro-5-nitropyridin-4-amine

Uses
Product Name
2-Chloro-5-nitropyridin-4-amine
CAS No.
2604-39-9
Chemical Name
2-Chloro-5-nitropyridin-4-amine
Synonyms
2-Chloro-5-nitropyridin-4-amine;2-Chloro-4-aMino-5-nitropyridine;4-Pyridinamine,2-chloro-5-nitro-;4-Amino-2-chloro-5-nitro-pyridine;2-Chloro-5-nitro-pyridin-4-ylamine;4-Amino-2-chloro-5-nitropyridine 98%;2-chloro-5-nitropyridin-4-amine, 98%min;2-Chloro-5-nitropyridin-4-amine ISO 9001：2015 REACH
CBNumber
CB81010059
Molecular Formula
C5H4ClN3O2
Formula Weight
173.56
MOL File
2604-39-9.mol
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2-Chloro-5-nitropyridin-4-amine Property

Melting point:
155-156 °C
Boiling point:
388.5±37.0 °C(Predicted)
Density 
1.596±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
0.63±0.42(Predicted)
color 
Brown
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Safety

Hazard Codes 
Xn
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C367558
Product name
2-Chloro-5-nitropyridin-4-amine
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR15938
Product name
4-Amino-2-chloro-5-nitropyridine
Purity
98%
Packaging
100mg
Price
$18
Updated
2021/12/16
SynQuest Laboratories
Product number
4H55-5-X8
Product name
4-Amino-2-chloro-5-nitropyridine
Packaging
100mg
Price
$20
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA55677
Product name
4-Amino-2-chloro-5-nitropyridine
Packaging
500mg
Price
$40
Updated
2021/12/16
Apolloscientific
Product number
OR15938
Product name
4-Amino-2-chloro-5-nitropyridine
Purity
98%
Packaging
1g
Price
$43
Updated
2021/12/16
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2-Chloro-5-nitropyridin-4-amine Chemical Properties,Usage,Production

Uses

2-Chloro-4-amino-5-nitropyridine is an intermediate of benzimidazole derivatives used to treat diseases such as bone development disorders; it is also an intermediate of a PLK1 recombinant protein inhibitor used to treat cell proliferation disorders, especially cancer.

Chemical Properties

white to light yellow crystal powder

Synthesis

14432-13-4

2604-39-9

2789-25-5

2-Chloro-4-nitroaminopyridine (CAS: 14432-13-4, 10.0 g) was used as a raw material, which was carefully dissolved in 100 mL of concentrated sulfuric acid at room temperature, followed by heating the reaction at 100 °C for 1 h. The reaction was carried out at room temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into 250 g of crushed ice. The pH of the mixture was adjusted to 3 with concentrated ammonium hydroxide under ice bath conditions, ensuring that the temperature was maintained below 20 °C. Subsequently, the resulting yellow solid was separated and the aqueous layer was extracted with ethyl acetate (200 mL × 3). The organic layers were combined, concentrated, and the residue was purified by silica gel column chromatography (eluent ratio: hexane:EtOAc = 4:1 to pure EtOAc, v/v) to give 6.0 g of 4-amino-2-chloro-3-nitropyridine in 70% yield and 2.0 g of 4-amino-2-chloro-5-nitropyridine in 25% yield. The properties of 4-amino-2-chloro-3-nitropyridine were as follows: melting point 179-181 °C; UV(H2O) λmax 238.0 nm (ε 13586, pH 11); 1H-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 13C-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 1.0 g 4-amino-2-chloro-5-nitropyridine, yield 25%. 1H); 13C-NMR (DMSO, 125 MHz) δ 149.54, 149.24, 142.69, 142.33, 122.45. The 1H-NMR (DMSO, 500 MHz) data of 4-amino-2-chloro-5-nitropyridine were as follows: δ 8.85 (s, 1H), 7.37 (s, 2H), 6.96 (s, 1H).

References

[1] Patent: WO2007/47793, 2007, A2. Location in patent: Page/Page column 87
[2] Roczniki Chemii, 1956, vol. 30, p. 1139,1144
[3] Chem.Abstr., 1957, p. 12089
[4] Nucleosides, nucleotides and nucleic acids, 2004, vol. 23, # 1-2, p. 67 - 76
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 38, p. 6526 - 6545

2-Chloro-5-nitropyridin-4-amine Preparation Products And Raw materials

Raw materials

4-Amino-2-chloropyridine Ammonium hydroxide Ethyl acetate Nitric acid PETROLEUM ETHER Sulfuric acid

Preparation Products

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2-Chloro-5-nitropyridin-4-amine Suppliers

China 162 Germany 1 India 5 United Kingdom 3 United States 16 Global 187
Jiaxing Rich Biological Technology Co., Ltd.
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0573-11111111-1111 18969316891
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richmol@163.com
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China
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50
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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JinYan Chemicals(ShangHai) Co.,Ltd.
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13817811078
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86-021-50426522,50426273
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sales@jingyan-chemical.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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sales@chemreagents.com
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United States
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005 13585536065
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021-58099609
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bin.wu@shlschem.com
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China
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9883
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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China
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
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China
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View Lastest Price from 2-Chloro-5-nitropyridin-4-amine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Chloro-5-nitropyridin-4-amine 2604-39-9
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-26
Dideu Industries Group Limited
Product
2-Chloro-5-nitropyridin-4-amine 2604-39-9
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-08
Career Henan Chemical Co
Product
2-Chloro-5-nitropyridin-4-amine 2604-39-9
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-08

2604-39-9, 2-Chloro-5-nitropyridin-4-amineRelated Search:

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  • 2-Chloro-5-nitropyridin-4-amine ISO 9001：2015 REACH
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