2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE

Product Name: 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
CAS No.: 2897-43-0
Chemical Name: 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
Synonyms: 2,6-Dichloro-3-nitropyridin-4-amine;2,6-Dichloro-3-nitro-pyridin-4-ylamine;NSC 136572;PYRIDINE DERIVATIVE2897-43-0;6-DICHLORO-3-NITRO-4-AMINOPYRIDINE;2,6-dichloro-3-nitro-4-Pyridinamine;2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE;2,6-dichloro-4-aMino-3-nitropyridine;2,6-Dichloro-4-amino-5-nitropyridine;5-Amino-2,6-dichloro-3-nitropyridine
CBNumber: CB71076007
Molecular Formula: C5H3Cl2N3O2
Formula Weight: 208
MOL File: 2897-43-0.mol

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2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE Property

Melting point:: 148-150°C
Boiling point:: 426.6±40.0 °C(Predicted)
Density: 1.723
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: soluble in Chloroform, Methanol
pka: -3.65±0.50(Predicted)
form: powder
color: Light yellow to light beige
InChI: InChI=1S/C5H3Cl2N3O2/c6-3-1-2(8)4(10(11)12)5(7)9-3/h1H,(H2,8,9)
InChIKey: KJVKGYRFRFXCQQ-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=CC(N)=C1[N+]([O-])=O

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A604660
Product name: 4-Amino-2,6-dichloro-3-nitropyridine
Packaging: 250mg
Price: $60
Updated: 2021/12/16

TRC

Product number: A604660
Product name: 4-Amino-2,6-dichloro-3-nitropyridine
Packaging: 500mg
Price: $95
Updated: 2021/12/16

TRC

Product number: A604660
Product name: 4-Amino-2,6-dichloro-3-nitropyridine
Packaging: 2g
Price: $270
Updated: 2021/12/16

ChemScene

Product number: CS-W003036
Product name: 2,6-Dichloro-3-nitropyridin-4-amine
Purity: 99.03%
Packaging: 25g
Price: $167
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA14524
Product name: 4-Amino-2,6-dichloro-3-nitropyridine
Packaging: 25g
Price: $375
Updated: 2021/12/16

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2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Light Yellow to Beige Solid

Uses

2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE is a synthetic compound that inhibits tyrosine kinases. It is an isomer of 2,6-Dichloropyridine and has been shown to inhibit the growth of lymphoma cells in vitro. 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE has three substitutions on the pyridine ring as compared to 2,6-Dichloropyridine. The substitutions are thought to be responsible for the increased hydrophilic properties of this compound. This may lead to increased cellular uptake and better bioavailability.

Synthesis

2587-03-3

2897-43-0

2,6-Dichloro-4-nitroaminopyridine (CAS: 2587-03-3, 1.66 g, 7.98 mmol) was used as a raw material, which was slowly added to 11 mL of concentrated sulfuric acid and stirred until completely dissolved. The reaction mixture was heated on a steam bath for 30 min. Upon completion of the reaction, the solution was cooled to room temperature and slowly poured into 28 g of crushed ice, which immediately formed a brown precipitate. The mixture was further cooled in an ice bath and the pH was adjusted dropwise to 7 by adding concentrated ammonium hydroxide solution.Subsequently, the reaction slurry was allowed to stand at -10 °C overnight. On the following day, the precipitate was collected by filtration through a Büchner funnel, washed thoroughly with pre-cooled deionized water and finally dried in a vacuum drying oven to afford the target product 4-amino-2,6-dichloro-3-nitropyridine (1.30 g, 78% yield) as a light tan solid.

References

[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1511 - 1530
[2] Patent: WO2006/13195, 2006, A1. Location in patent: Page/Page column 44
[3] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51; 53
[4] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58-60
[5] Patent: WO2017/216293, 2017, A1. Location in patent: Page/Page column 67

2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE Suppliers

Canada 1 China 152 India 11 Switzerland 1 United Kingdom 3 United States 18 Global 186

Suzhou Sino Rare Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Energy Chemical

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Pure Chemistry Scientific Inc.

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Accela ChemBio Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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View Lastest Price from 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE manufacturers

Hubei Lidu New Material Technology Co., Ltd

Product: 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE 2897-43-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20t
Release date: 2024-12-11

Dideu Industries Group Limited

Product: 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE 2897-43-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-08

Career Henan Chemical Co

Product: 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE 2897-43-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

2897-43-0, 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINERelated Search:

4-AMINO-2,6-DICHLOROPHENOL HYDROCHLORIDE 4-AMINO-2,6-DIFLUOROPHENOL N2-ethylpyridine-2,4-diamine 4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde 4-Pyrimidinamine, 2-methoxy- (9CI) 4-AMINO-2,6-DIBROMOPHENOL TIN(II)CHLORIDE HYDROCHLORIDE ethyl 4-amino-2-methylpyrimidine-5-carboxylate 2-Chloro-3,4-diaminopyridine (3alpha)-3-chloro-Cholest-4-ene 2-Chloro-5-nitropyridin-4-amine 6-chloropyridine-3,4-diamine hydrochloride 4-Amino-2-chloro-3-nitropyridine 6-CHLORO-3,4-PYRIDINEDIAMINE 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE 2,6-Dichloropyridin-3-amine 2-CHLORO-3-NITROPYRIDINE 2,6-DICHLOROPYRIDINE-3,4-DIAMINE 2,6-DICHLORO-3,5-DINITRO-4-AMINOPYRIDINE

2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE

2,6-dichloro-3-nitro-4-Pyridinamine

2,6-Dichloro-3-nitropyridin-4-amine

2,6-Dichloro-3-nitro-pyridin-4-ylamine

NSC 136572

(2,6-dichloro-3-nitro-4-pyridyl)amine

2,6-Dichloro-4-amino-5-nitropyridine

2,6-dichloro-4-aMino-3-nitropyridine

4-Pyridinamine, 2,6-dichloro-3-nitro-

4-amino-2,6-dichloro-3-nitropyrimidine

2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE ISO 9001：2015 REACH

6-DICHLORO-3-NITRO-4-AMINOPYRIDINE

5-Amino-2,6-dichloro-3-nitropyridine

PYRIDINE DERIVATIVE2897-43-0

4-AMINO-2,6-DICHLORO-3-NITROPYRIDINE 95%

2897-43-0

Heterocycle-Pyridine series

Heterocycles

Pyridine

Bases & Related Reagents

Nucleotides

Nucleotides and Nucleosides

Amines

Aromatics