ChemicalBook > CAS DataBase List > 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
- Product Name
- 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
- CAS No.
- 2897-43-0
- Chemical Name
- 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
- Synonyms
- 2,6-Dichloro-3-nitropyridin-4-amine;2,6-Dichloro-3-nitro-pyridin-4-ylamine;NSC 136572;PYRIDINE DERIVATIVE2897-43-0;6-DICHLORO-3-NITRO-4-AMINOPYRIDINE;2,6-dichloro-3-nitro-4-Pyridinamine;2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE;2,6-dichloro-4-aMino-3-nitropyridine;2,6-Dichloro-4-amino-5-nitropyridine;5-Amino-2,6-dichloro-3-nitropyridine
- CBNumber
- CB71076007
- Molecular Formula
- C5H3Cl2N3O2
- Formula Weight
- 208
- MOL File
- 2897-43-0.mol
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2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE Property
- Melting point:
- 148-150°C
- Boiling point:
- 426.6±40.0 °C(Predicted)
- Density
- 1.723
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- soluble in Chloroform, Methanol
- pka
- -3.65±0.50(Predicted)
- form
- powder
- color
- Light yellow to light beige
- InChI
- InChI=1S/C5H3Cl2N3O2/c6-3-1-2(8)4(10(11)12)5(7)9-3/h1H,(H2,8,9)
- InChIKey
- KJVKGYRFRFXCQQ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC(N)=C1[N+]([O-])=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- A604660
- Product name
- 4-Amino-2,6-dichloro-3-nitropyridine
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
TRC
- Product number
- A604660
- Product name
- 4-Amino-2,6-dichloro-3-nitropyridine
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
TRC
- Product number
- A604660
- Product name
- 4-Amino-2,6-dichloro-3-nitropyridine
- Packaging
- 2g
- Price
- $270
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA14524
- Product name
- 4-Amino-2,6-dichloro-3-nitropyridine
- Packaging
- 2g
- Price
- $50
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W003036
- Product name
- 2,6-Dichloro-3-nitropyridin-4-amine
- Purity
- 99.03%
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
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2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
Light Yellow to Beige Solid
Uses
2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE is a synthetic compound that inhibits tyrosine kinases. It is an isomer of 2,6-Dichloropyridine and has been shown to inhibit the growth of lymphoma cells in vitro. 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE has three substitutions on the pyridine ring as compared to 2,6-Dichloropyridine. The substitutions are thought to be responsible for the increased hydrophilic properties of this compound. This may lead to increased cellular uptake and better bioavailability.
Synthesis
2587-03-3
2897-43-0
2,6-Dichloro-4-nitroaminopyridine (CAS: 2587-03-3, 1.66 g, 7.98 mmol) was used as a raw material, which was slowly added to 11 mL of concentrated sulfuric acid and stirred until completely dissolved. The reaction mixture was heated on a steam bath for 30 min. Upon completion of the reaction, the solution was cooled to room temperature and slowly poured into 28 g of crushed ice, which immediately formed a brown precipitate. The mixture was further cooled in an ice bath and the pH was adjusted dropwise to 7 by adding concentrated ammonium hydroxide solution.Subsequently, the reaction slurry was allowed to stand at -10 °C overnight. On the following day, the precipitate was collected by filtration through a Büchner funnel, washed thoroughly with pre-cooled deionized water and finally dried in a vacuum drying oven to afford the target product 4-amino-2,6-dichloro-3-nitropyridine (1.30 g, 78% yield) as a light tan solid.
References
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 3, p. 1511 - 1530
[2] Patent: WO2006/13195, 2006, A1. Location in patent: Page/Page column 44
[3] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51; 53
[4] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58-60
[5] Patent: WO2017/216293, 2017, A1. Location in patent: Page/Page column 67
2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE manufacturers
Hubei Lidu New Material Technology Co., Ltd
- Product
- 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE 2897-43-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20t
- Release date
- 2024-12-11
Dideu Industries Group Limited
- Product
- 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE 2897-43-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-08
Career Henan Chemical Co
- Product
- 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE 2897-43-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07
2897-43-0, 2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINERelated Search:
4-AMINO-2,6-DICHLOROPHENOL HYDROCHLORIDE
4-AMINO-2,6-DIFLUOROPHENOL
N2-ethylpyridine-2,4-diamine
4-Amino-2-(methylthio)pyrimidine-5-carbaldehyde
4-Pyrimidinamine, 2-methoxy- (9CI)
4-AMINO-2,6-DIBROMOPHENOL TIN(II)CHLORIDE HYDROCHLORIDE
ethyl 4-amino-2-methylpyrimidine-5-carboxylate
2-Chloro-3,4-diaminopyridine
(3alpha)-3-chloro-Cholest-4-ene
2-Chloro-5-nitropyridin-4-amine
6-chloropyridine-3,4-diamine hydrochloride
4-Amino-2-chloro-3-nitropyridine
6-CHLORO-3,4-PYRIDINEDIAMINE
2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE
2,6-Dichloropyridin-3-amine
2-CHLORO-3-NITROPYRIDINE
2,6-DICHLOROPYRIDINE-3,4-DIAMINE
2,6-DICHLORO-3,5-DINITRO-4-AMINOPYRIDINE