4-Amino-2-chloro-3-nitropyridine

Product Name: 4-Amino-2-chloro-3-nitropyridine
CAS No.: 2789-25-5
Chemical Name: 4-Amino-2-chloro-3-nitropyridine
Synonyms: 2-chloro-3-nitro-;2-CHLORO-3-NITROPYRIDIN-4-AMINE;2-Chloro-3-nitro-4-pyridinamine;4-Amino-3-nitro-2-chloropyridine;4-AMINO-2-CHLORO-3-NITROPYRIDINE;2-Chloro-4-aMino-3-nitropyridine;2-Chloro-3-nitro-4-aminopyridine;4-Pyridinamine, 2-chloro-3-nitro-;2-Chloro-3-nitro-pyridin-4-ylaMine;2-Chloro-3-nitropyridin-4-amine ,98%
CBNumber: CB7304271
Molecular Formula: C5H4ClN3O2
Formula Weight: 173.56
MOL File: 2789-25-5.mol

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4-Amino-2-chloro-3-nitropyridine Property

Melting point:: 205-207 °C (decomp)
Boiling point:: 392.8±37.0 °C(Predicted)
Density: 1.596±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: powder to crystal
pka: 0.63±0.42(Predicted)
color: White to Yellow
λmax: 238nm(H2O)(lit.)
CAS DataBase Reference: 2789-25-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-43-36/37/38
Safety Statements: 36/37-37/39-26
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2798
Product name: 4-Amino-2-chloro-3-nitropyridine
Purity: >97.0%(GC)(T)
Packaging: 200mg
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: A2798
Product name: 4-Amino-2-chloro-3-nitropyridine
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $196
Updated: 2025/07/31

TRC

Product number: A604200
Product name: 4-Amino-2-chloro-3-nitropyridine
Packaging: 1g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA30254
Product name: 4-Amino-2-chloro-3-nitro pyridine
Packaging: 5G
Price: $230
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA30254
Product name: 4-Amino-2-chloro-3-nitro pyridine
Packaging: 10g
Price: $375
Updated: 2021/12/16

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4-Amino-2-chloro-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

4-Amino-2-chloro-3-nitropyridine is used as a reagent in the synthesis of imidazopyridine-based fatty acid synthase inhibitors which show anti-HCV activity. Also used as a reagent in the synthesis of acyclic nucleotides that are related to clitocine, which exhibit antiviral activity.

Synthesis

14432-13-4

2604-39-9

2789-25-5

2-Chloro-4-nitroaminopyridine (CAS: 14432-13-4, 10.0 g) was used as a raw material, which was slowly dissolved in 100 mL of concentrated sulfuric acid at room temperature, followed by heating the reaction mixture to 100 °C and maintaining it for 1 hour. Upon completion of the reaction, the solution was cooled to room temperature and slowly poured into 250 g of crushed ice. The pH of the mixture was adjusted to 3 with concentrated ammonium hydroxide under cooling in an ice bath while ensuring that the temperature did not exceed 20°C. The precipitated yellow solid was separated by filtration and the aqueous phase was extracted with ethyl acetate (200 mL × 3). The organic layers were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography with an eluent ratio of hexane:ethyl acetate (4:1 to pure ethyl acetate, v/v) to give 4-amino-2-chloro-3-nitropyridine (6.0 g, 70% yield) and 4-amino-2-chloro-5-nitropyridine (2.0 g, 25% yield). 4-amino-2-chloro-3-nitropyridine The physical properties were as follows: melting point 179-181 °C; UV (H2O) λmax 238.0 nm (ε 13586, pH 11); 1H-NMR (DMSO-d6, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 13C-NMR (DMSO-d6, 125 MHz) δ 149.54, 149.24, 142.69, 142.33, 122.45. 1H-NMR (DMSO-d6, 500 MHz) δ 8.85 (s, 1H), 7.37 (s, 2H), 6.96 (s, 1H) for 4-amino-2-chloro-5-nitropyridine.

References

[1] Patent: WO2007/47793, 2007, A2. Location in patent: Page/Page column 87
[2] Roczniki Chemii, 1956, vol. 30, p. 1139,1144
[3] Chem.Abstr., 1957, p. 12089
[4] Nucleosides, nucleotides and nucleic acids, 2004, vol. 23, # 1-2, p. 67 - 76
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 38, p. 6526 - 6545

4-Amino-2-chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

4-Amino-2-chloropyridine Ethanol Chloroform Nitric acid Sulfuric acid Ammonia

Preparation Products

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4-Amino-2-chloro-3-nitropyridine Suppliers

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View Lastest Price from 4-Amino-2-chloro-3-nitropyridine manufacturers

Dideu Industries Group Limited

Product: 4-Amino-2-chloro-3-nitropyridine 2789-25-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-08

Career Henan Chemical Co

Product: 4-Amino-2-chloro-3-nitropyridine 2789-25-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99.99%
Supply Ability: 1kg-10MT
Release date: 2019-05-24

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4-Amino-2-chloro-3-nitropyridine ISO 9001：2015 REACH

2789-25-5

Heterocycle-Pyridine series

amine|alkyl chloride |nitro-compound

Pyridine

Pyridines