4-Amino-2-chloro-3-nitropyridine
- Product Name
- 4-Amino-2-chloro-3-nitropyridine
- CAS No.
- 2789-25-5
- Chemical Name
- 4-Amino-2-chloro-3-nitropyridine
- Synonyms
- 2-chloro-3-nitro-;2-CHLORO-3-NITROPYRIDIN-4-AMINE;2-Chloro-3-nitro-4-pyridinamine;4-Amino-3-nitro-2-chloropyridine;4-AMINO-2-CHLORO-3-NITROPYRIDINE;2-Chloro-4-aMino-3-nitropyridine;2-Chloro-3-nitro-4-aminopyridine;4-Pyridinamine, 2-chloro-3-nitro-;2-Chloro-3-nitro-pyridin-4-ylaMine;2-Chloro-3-nitropyridin-4-amine ,98%
- CBNumber
- CB7304271
- Molecular Formula
- C5H4ClN3O2
- Formula Weight
- 173.56
- MOL File
- 2789-25-5.mol
4-Amino-2-chloro-3-nitropyridine Property
- Melting point:
- 205-207 °C (decomp)
- Boiling point:
- 392.8±37.0 °C(Predicted)
- Density
- 1.596±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- 0.63±0.42(Predicted)
- color
- White to Yellow
- λmax
- 238nm(H2O)(lit.)
- CAS DataBase Reference
- 2789-25-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-43-36/37/38
- Safety Statements
- 36/37-37/39-26
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- A2798
- Product name
- 4-Amino-2-chloro-3-nitropyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 200mg
- Price
- $65
- Updated
- 2025/07/31
- Product number
- A2798
- Product name
- 4-Amino-2-chloro-3-nitropyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $196
- Updated
- 2025/07/31
- Product number
- A604200
- Product name
- 4-Amino-2-chloro-3-nitropyridine
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 072546
- Product name
- 4-Amino-2-chloro-3-nitropyridine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 4H55-5-Y2
- Product name
- 4-Amino-2-chloro-3-nitropyridine
- Packaging
- 500mg
- Price
- $16
- Updated
- 2021/12/16
4-Amino-2-chloro-3-nitropyridine Chemical Properties,Usage,Production
Chemical Properties
Yellow solid
Uses
4-Amino-2-chloro-3-nitropyridine is used as a reagent in the synthesis of imidazopyridine-based fatty acid synthase inhibitors which show anti-HCV activity. Also used as a reagent in the synthesis of acyclic nucleotides that are related to clitocine, which exhibit antiviral activity.
Synthesis
14432-13-4
2604-39-9
2789-25-5
2-Chloro-4-nitroaminopyridine (CAS: 14432-13-4, 10.0 g) was used as a raw material, which was slowly dissolved in 100 mL of concentrated sulfuric acid at room temperature, followed by heating the reaction mixture to 100 °C and maintaining it for 1 hour. Upon completion of the reaction, the solution was cooled to room temperature and slowly poured into 250 g of crushed ice. The pH of the mixture was adjusted to 3 with concentrated ammonium hydroxide under cooling in an ice bath while ensuring that the temperature did not exceed 20°C. The precipitated yellow solid was separated by filtration and the aqueous phase was extracted with ethyl acetate (200 mL × 3). The organic layers were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography with an eluent ratio of hexane:ethyl acetate (4:1 to pure ethyl acetate, v/v) to give 4-amino-2-chloro-3-nitropyridine (6.0 g, 70% yield) and 4-amino-2-chloro-5-nitropyridine (2.0 g, 25% yield). 4-amino-2-chloro-3-nitropyridine The physical properties were as follows: melting point 179-181 °C; UV (H2O) λmax 238.0 nm (ε 13586, pH 11); 1H-NMR (DMSO-d6, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 13C-NMR (DMSO-d6, 125 MHz) δ 149.54, 149.24, 142.69, 142.33, 122.45. 1H-NMR (DMSO-d6, 500 MHz) δ 8.85 (s, 1H), 7.37 (s, 2H), 6.96 (s, 1H) for 4-amino-2-chloro-5-nitropyridine.
References
[1] Patent: WO2007/47793, 2007, A2. Location in patent: Page/Page column 87
[2] Roczniki Chemii, 1956, vol. 30, p. 1139,1144
[3] Chem.Abstr., 1957, p. 12089
[4] Nucleosides, nucleotides and nucleic acids, 2004, vol. 23, # 1-2, p. 67 - 76
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 38, p. 6526 - 6545
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View Lastest Price from 4-Amino-2-chloro-3-nitropyridine manufacturers
- Product
- 4-Amino-2-chloro-3-nitropyridine 2789-25-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-08
- Product
- 4-Amino-2-chloro-3-nitropyridine 2789-25-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99.99%
- Supply Ability
- 1kg-10MT
- Release date
- 2019-05-24