2-Chloro-5-nitropyridin-4-amine
Uses- Product Name
- 2-Chloro-5-nitropyridin-4-amine
- CAS No.
- 2604-39-9
- Chemical Name
- 2-Chloro-5-nitropyridin-4-amine
- Synonyms
- 2-Chloro-5-nitropyridin-4-amine;2-Chloro-4-aMino-5-nitropyridine;4-Pyridinamine,2-chloro-5-nitro-;4-Amino-2-chloro-5-nitro-pyridine;2-Chloro-5-nitro-pyridin-4-ylamine;4-Amino-2-chloro-5-nitropyridine 98%;2-chloro-5-nitropyridin-4-amine, 98%min;2-Chloro-5-nitropyridin-4-amine ISO 9001：2015 REACH
- CBNumber
- CB81010059
- Molecular Formula
- C5H4ClN3O2
- Formula Weight
- 173.56
- MOL File
- 2604-39-9.mol
2-Chloro-5-nitropyridin-4-amine Property
- Melting point:
- 155-156 °C
- Boiling point:
- 388.5±37.0 °C(Predicted)
- Density
- 1.596±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 0.63±0.42(Predicted)
- color
- Brown
Safety
- Hazard Codes
- Xn
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C367558
- Product name
- 2-Chloro-5-nitropyridin-4-amine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W4940
- Product name
- 4-Amino-2-chloro-5-nitropyridine
- Packaging
- 1g
- Price
- $97
- Updated
- 2021/12/16
- Product number
- FA55677
- Product name
- 4-Amino-2-chloro-5-nitropyridine
- Packaging
- 500mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- OR15938
- Product name
- 4-Amino-2-chloro-5-nitropyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- 4H55-5-X8
- Product name
- 4-Amino-2-chloro-5-nitropyridine
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
2-Chloro-5-nitropyridin-4-amine Chemical Properties,Usage,Production
Uses
2-Chloro-4-amino-5-nitropyridine is an intermediate of benzimidazole derivatives used to treat diseases such as bone development disorders; it is also an intermediate of a PLK1 recombinant protein inhibitor used to treat cell proliferation disorders, especially cancer.
Chemical Properties
white to light yellow crystal powder
Synthesis
14432-13-4
2604-39-9
2789-25-5
2-Chloro-4-nitroaminopyridine (CAS: 14432-13-4, 10.0 g) was used as a raw material, which was carefully dissolved in 100 mL of concentrated sulfuric acid at room temperature, followed by heating the reaction at 100 °C for 1 h. The reaction was carried out at room temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into 250 g of crushed ice. The pH of the mixture was adjusted to 3 with concentrated ammonium hydroxide under ice bath conditions, ensuring that the temperature was maintained below 20 °C. Subsequently, the resulting yellow solid was separated and the aqueous layer was extracted with ethyl acetate (200 mL × 3). The organic layers were combined, concentrated, and the residue was purified by silica gel column chromatography (eluent ratio: hexane:EtOAc = 4:1 to pure EtOAc, v/v) to give 6.0 g of 4-amino-2-chloro-3-nitropyridine in 70% yield and 2.0 g of 4-amino-2-chloro-5-nitropyridine in 25% yield. The properties of 4-amino-2-chloro-3-nitropyridine were as follows: melting point 179-181 °C; UV(H2O) λmax 238.0 nm (ε 13586, pH 11); 1H-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 13C-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 1.0 g 4-amino-2-chloro-5-nitropyridine, yield 25%. 1H); 13C-NMR (DMSO, 125 MHz) δ 149.54, 149.24, 142.69, 142.33, 122.45. The 1H-NMR (DMSO, 500 MHz) data of 4-amino-2-chloro-5-nitropyridine were as follows: δ 8.85 (s, 1H), 7.37 (s, 2H), 6.96 (s, 1H).
References
[1] Patent: WO2007/47793, 2007, A2. Location in patent: Page/Page column 87
[2] Roczniki Chemii, 1956, vol. 30, p. 1139,1144
[3] Chem.Abstr., 1957, p. 12089
[4] Nucleosides, nucleotides and nucleic acids, 2004, vol. 23, # 1-2, p. 67 - 76
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 38, p. 6526 - 6545
2-Chloro-5-nitropyridin-4-amine Preparation Products And Raw materials
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View Lastest Price from 2-Chloro-5-nitropyridin-4-amine manufacturers
- Product
- 2-Chloro-5-nitropyridin-4-amine 2604-39-9
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-26
- Product
- 2-Chloro-5-nitropyridin-4-amine 2604-39-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-08
- Product
- 2-Chloro-5-nitropyridin-4-amine 2604-39-9
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-08