ChemicalBook > CAS DataBase List > 5-BROMO-1-METHYL-1H-INDAZOLE

5-BROMO-1-METHYL-1H-INDAZOLE

Product Name: 5-BROMO-1-METHYL-1H-INDAZOLE
CAS No.: 465529-57-1
Chemical Name: 5-BROMO-1-METHYL-1H-INDAZOLE
Synonyms: SW-5;SWF-5;Orforglipron impurity 27;5-BROMO-1-METHYLINDAZOLE;1-Methyl-5-bromoindazole;1-Methyl-5-bromo-1H-indazole;5-BROMO-1-METHYL-1H-INDAZOLE;5-Bromo-1-mehtyl-1H-indazole;1H-INDAZOLE, 5-BROMO-1-METHYL-;5-bromo-1-methyl-1H-indazole, N1-methyl-5-bromoindazole, 5-bromo-1-methylindazole, 5-bromo-1-methyl-1H-indazole, 5-Brom-1-methyl-1H-indazol, N-1-methyl-5-bromoindazole
CBNumber: CB71499813
Molecular Formula: C8H7BrN2
Formula Weight: 211.06
MOL File: 465529-57-1.mol

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5-BROMO-1-METHYL-1H-INDAZOLE Property

Melting point:: 111-112 °C(Solv: ligroine (8032-32-4))
Boiling point:: 293.6±13.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 0.36±0.30(Predicted)
color: Orange
InChI: InChI=1S/C8H7BrN2/c1-11-8-3-2-7(9)4-6(8)5-10-11/h2-5H,1H3
InChIKey: RMCHMXPTUMFFBZ-UHFFFAOYSA-N
SMILES: N1(C)C2=C(C=C(Br)C=C2)C=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B688985
Product name: 5-Bromo-1-methyl-1H-indazole
Packaging: 1g
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 284448
Product name: 1-Methyl-5-bromoindazole
Packaging: 250mg
Price: $350
Updated: 2021/12/16

TRC

Product number: B688985
Product name: 5-Bromo-1-methyl-1H-indazole
Packaging: 10g
Price: $440
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0359221
Product name: 5-BROMO-1-METHYL-1H-INDAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $495.81
Updated: 2021/12/16

Matrix Scientific

Product number: 069656
Product name: 5-Bromo-1-methyl-1H-indazole
Purity: 98%
Packaging: 1g
Price: $341
Updated: 2021/12/16

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5-BROMO-1-METHYL-1H-INDAZOLE Chemical Properties,Usage,Production

Uses

5-?Bromo-?1-?methyl-1H-?indazole is an antibacterial drugs with inhibitory activity against multidrug-resistant (MDR) pathogens.

Synthesis

53857-57-1

74-88-4

465529-56-0

465529-57-1

5-Bromoindazole (590 mg, 2.99 mmol) was dissolved in tetrahydrofuran (10 mL) and stirred under ice bath conditions and sodium hydride (180 mg, 80% dispersed in mineral oil, 6.00 mmol) was added slowly. After stirring for 30 minutes, iodomethane (468 mg, 3.30 mmol) was added and stirring was continued for 3 hours. After completion of the reaction, the reaction mixture was warmed to room temperature and the reaction was quenched by the addition of water (20 mL). The reaction was extracted with ethyl acetate (20 mL × 3), and the organic phases were combined and washed with saturated saline (50 mL × 3). The organic phase was dried with anhydrous sodium sulfate, filtered and the solvent was removed by rotary evaporation. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 3:1) to afford 5-bromo-2-methyl-2H-indazole (A14-2, 230 mg, 36%) and 1-methyl-5-bromo-1H-indazole (A14-3, 330 mg, 52%).A14-2 was an off-white solid, 1H NMR (400 MHz, DMSO ) δ 8.33 (s, 1H), 7.96-7.95 (m, 1H), 7.57 (d, J = 9.2 Hz, 1H), 7.31-7.28 (m, 1H), 4.16 (s, 3H).A14-3 is a white solid.

References

[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0131; 0132; 0133; 0134; 0135
[2] Journal of Organic Chemistry, 2018, vol. 83, # 12, p. 6334 - 6353
[3] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 60-61
[4] Patent: WO2011/20861, 2011, A1. Location in patent: Page/Page column 59
[5] Chemische Berichte, 1922, vol. 55, p. 1141,1157

5-BROMO-1-METHYL-1H-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-BROMO-1-METHYL-1H-INDAZOLE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-1-METHYL-1H-INDAZOLE 465529-57-1
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

465529-57-1, 5-BROMO-1-METHYL-1H-INDAZOLERelated Search:

5-Bromo-2-methoxyphenol 6-BROMO-1-METHYL-1H-INDAZOLE 5-BROMO-2-METHYL-2H-INDAZOLE 5-BROMO-7-METHYL-1H-INDOLE-2,3-DIONE 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 1-METHYL-5-NITRO-1H-INDAZOLE 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl No Chinese name (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate 3-Fluoro-4-broMo-6-aMinotoluene 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Pyrrolidine-3-carboxaMide hydrochloride 5-Bromoindazole (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate 2-cyclopylcyclopropane-1-carboxylic acid

5-BROMO-1-METHYL-1H-INDAZOLE

1H-INDAZOLE, 5-BROMO-1-METHYL-

5-BROMO-1-METHYLINDAZOLE

5-Bromo-1-mehtyl-1H-indazole

1-Methyl-5-bromoindazole

1-Methyl-5-bromo-1H-indazole

5-bromo-1-methyl-1H-indazole, N1-methyl-5-bromoindazole, 5-bromo-1-methylindazole, 5-bromo-1-methyl-1H-indazole, 5-Brom-1-methyl-1H-indazol, N-1-methyl-5-bromoindazole

SWF-5

SW-5

Orforglipron impurity 27

465529-57-1

Indazoles

Indazole

Organohalides