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5-BROMO-1-METHYL-1H-INDAZOLE

Product Name
5-BROMO-1-METHYL-1H-INDAZOLE
CAS No.
465529-57-1
Chemical Name
5-BROMO-1-METHYL-1H-INDAZOLE
Synonyms
SW-5;SWF-5;Orforglipron impurity 27;5-BROMO-1-METHYLINDAZOLE;1-Methyl-5-bromoindazole;1-Methyl-5-bromo-1H-indazole;5-BROMO-1-METHYL-1H-INDAZOLE;5-Bromo-1-mehtyl-1H-indazole;1H-INDAZOLE, 5-BROMO-1-METHYL-;5-bromo-1-methyl-1H-indazole, N1-methyl-5-bromoindazole, 5-bromo-1-methylindazole, 5-bromo-1-methyl-1H-indazole, 5-Brom-1-methyl-1H-indazol, N-1-methyl-5-bromoindazole
CBNumber
CB71499813
Molecular Formula
C8H7BrN2
Formula Weight
211.06
MOL File
465529-57-1.mol
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5-BROMO-1-METHYL-1H-INDAZOLE Property

Melting point:
111-112 °C(Solv: ligroine (8032-32-4))
Boiling point:
293.6±13.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
0.36±0.30(Predicted)
color 
Orange
InChI
InChI=1S/C8H7BrN2/c1-11-8-3-2-7(9)4-6(8)5-10-11/h2-5H,1H3
InChIKey
RMCHMXPTUMFFBZ-UHFFFAOYSA-N
SMILES
N1(C)C2=C(C=C(Br)C=C2)C=N1
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Safety

Hazard Codes 
Xn
Risk Statements 
22
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B688985
Product name
5-​Bromo-​1-​methyl-1H-​indazole
Packaging
1g
Price
$120
Updated
2021/12/16
Usbiological
Product number
284448
Product name
1-Methyl-5-bromoindazole
Packaging
250mg
Price
$350
Updated
2021/12/16
TRC
Product number
B688985
Product name
5-​Bromo-​1-​methyl-1H-​indazole
Packaging
10g
Price
$440
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0359221
Product name
5-BROMO-1-METHYL-1H-INDAZOLE
Purity
95.00%
Packaging
5MG
Price
$495.81
Updated
2021/12/16
Matrix Scientific
Product number
069656
Product name
5-Bromo-1-methyl-1H-indazole
Purity
98%
Packaging
1g
Price
$341
Updated
2021/12/16
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5-BROMO-1-METHYL-1H-INDAZOLE Chemical Properties,Usage,Production

Uses

5-?Bromo-?1-?methyl-1H-?indazole is an antibacterial drugs with inhibitory activity against multidrug-resistant (MDR) pathogens.

Synthesis

53857-57-1

74-88-4

465529-56-0

465529-57-1

5-Bromoindazole (590 mg, 2.99 mmol) was dissolved in tetrahydrofuran (10 mL) and stirred under ice bath conditions and sodium hydride (180 mg, 80% dispersed in mineral oil, 6.00 mmol) was added slowly. After stirring for 30 minutes, iodomethane (468 mg, 3.30 mmol) was added and stirring was continued for 3 hours. After completion of the reaction, the reaction mixture was warmed to room temperature and the reaction was quenched by the addition of water (20 mL). The reaction was extracted with ethyl acetate (20 mL × 3), and the organic phases were combined and washed with saturated saline (50 mL × 3). The organic phase was dried with anhydrous sodium sulfate, filtered and the solvent was removed by rotary evaporation. The residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 3:1) to afford 5-bromo-2-methyl-2H-indazole (A14-2, 230 mg, 36%) and 1-methyl-5-bromo-1H-indazole (A14-3, 330 mg, 52%).A14-2 was an off-white solid, 1H NMR (400 MHz, DMSO ) δ 8.33 (s, 1H), 7.96-7.95 (m, 1H), 7.57 (d, J = 9.2 Hz, 1H), 7.31-7.28 (m, 1H), 4.16 (s, 3H).A14-3 is a white solid.

References

[1] Patent: CN105254613, 2016, A. Location in patent: Paragraph 0131; 0132; 0133; 0134; 0135
[2] Journal of Organic Chemistry, 2018, vol. 83, # 12, p. 6334 - 6353
[3] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 60-61
[4] Patent: WO2011/20861, 2011, A1. Location in patent: Page/Page column 59
[5] Chemische Berichte, 1922, vol. 55, p. 1141,1157

5-BROMO-1-METHYL-1H-INDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-BROMO-1-METHYL-1H-INDAZOLE Suppliers

China 136 Germany 1 India 3 United Kingdom 1 United States 15 Global 156
Vignasai Laboratories Private Limited
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India
ProdList
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Advantage
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A.J Chemicals
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Email
sales@ajchem.in
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India
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View Lastest Price from 5-BROMO-1-METHYL-1H-INDAZOLE manufacturers

Career Henan Chemical Co
Product
5-BROMO-1-METHYL-1H-INDAZOLE 465529-57-1
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-04

465529-57-1, 5-BROMO-1-METHYL-1H-INDAZOLERelated Search:

5-Bromo-2-methoxyphenol 6-BROMO-1-METHYL-1H-INDAZOLE 5-BROMO-2-METHYL-2H-INDAZOLE 5-BROMO-7-METHYL-1H-INDOLE-2,3-DIONE 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 1-METHYL-5-NITRO-1H-INDAZOLE 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl No Chinese name (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate 3-Fluoro-4-broMo-6-aMinotoluene 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- Pyrrolidine-3-carboxaMide hydrochloride 5-Bromoindazole (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate 2-cyclopylcyclopropane-1-carboxylic acid

  • 5-BROMO-1-METHYL-1H-INDAZOLE
  • 1H-INDAZOLE, 5-BROMO-1-METHYL-
  • 5-BROMO-1-METHYLINDAZOLE
  • 5-Bromo-1-mehtyl-1H-indazole
  • 1-Methyl-5-bromoindazole
  • 1-Methyl-5-bromo-1H-indazole
  • 5-bromo-1-methyl-1H-indazole, N1-methyl-5-bromoindazole, 5-bromo-1-methylindazole, 5-bromo-1-methyl-1H-indazole, 5-Brom-1-methyl-1H-indazol, N-1-methyl-5-bromoindazole
  • SWF-5
  • SW-5
  • Orforglipron impurity 27
  • 465529-57-1
  • Indazoles
  • Indazole
  • Organohalides