3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane

Product Name: 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane
CAS No.: 114214-49-2
Chemical Name: 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane
Synonyms: SW-39;SWF-39;VOSA-011;o[3.1.0]hexane;3-Boc-6-oxa-3-azabicycL;3-Boc-6-oxa-3-aza-bicyclo;1-Boc-3,4-epoxypyrrolidine;N-Boc-6-Oxa-3-azabicyclo[3.1.0]hexane;3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane;1-(tert-Butoxycarbonyl)-3,4-epoxypyrrolidine
CBNumber: CB71501400
Molecular Formula: C9H15NO3
Formula Weight: 185.22
MOL File: 114214-49-2.mol

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3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane Property

Boiling point:: 252.7±33.0 °C(Predicted)
Density: 1.181±0.06 g/cm3(Predicted)
refractive index: 1.4600 to 1.4640
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: powder to lump to clear liquid
pka: -0.98±0.20(Predicted)
color: White or Colorless to Light yellow
InChI: InChI=1S/C9H15NO3/c1-9(2,3)13-8(11)10-4-6-7(5-10)12-6/h6-7H,4-5H2,1-3H3
InChIKey: NXZIGGBPLGAPTI-UHFFFAOYSA-N
SMILES: C12C(O1)CN(C(OC(C)(C)C)=O)C2

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5385
Product name: tert-Butyl 6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate
Purity: >95.0%(GC)
Packaging: 1g
Price: $41
Updated: 2025/07/31

TCI Chemical

Product number: B5385
Product name: tert-Butyl 6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate
Purity: >95.0%(GC)
Packaging: 5g
Price: $152
Updated: 2025/07/31

TRC

Product number: O752195
Product name: 6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylicAcidtert-ButylEster
Packaging: 1g
Price: $140
Updated: 2021/12/16

Usbiological

Product number: 162185
Product name: 6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid tert-Butyl Ester
Packaging: 1g
Price: $425
Updated: 2021/12/16

TRC

Product number: O752195
Product name: 6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylicAcidtert-ButylEster
Packaging: 10g
Price: $1100
Updated: 2021/12/16

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3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane Chemical Properties,Usage,Production

Uses

6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylic Acid tert-Butyl Ester, can be used as an intermediate in the synthesis of pharmaceutical products including inhibitors and anticancer compounds. It is used in the synthesis of chiral pyrrolidine Inhibitors with the ability to bind to Neuronal Nitric Oxide Synthase.

Synthesis

73286-70-1

114214-49-2

General procedure for the synthesis of 3-N-Boc-6-oxa-3-azabicyclo[3.1.0]hexane from N-Boc-3-pyrroline: compound 1 (N-Boc-3-pyrroline, 4.0 g, 0.024 mol) was dissolved in dichloromethane (40 mL) at room temperature followed by the addition of isochloroperoxybenzoic acid (m-CPBA, 0.3 mol) . The reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the reaction was quenched with sodium sulfite (Na2SO3), followed by washing the organic layer with sodium bicarbonate (NaHCO3) solution. Finally, the organic phase was concentrated to give compound 2 (3-N-tert-butoxycarbonyl-6-oxa-3-azabicyclo[3.1.0]hexane, 4.4 g, 100% yield). The 1H NMR (400 MHz, CDCl3) data of compound 2 were as follows: δ 3.73 (multiple peaks, 2H), 3.60 (multiple peaks, 2H), 3.23 (multiple peaks, 2H), 1.37 (single peak, 9H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 21, p. 4770 - 4773
[2] Patent: WO2013/96744, 2013, A1. Location in patent: Page/Page column 221
[3] Patent: US2007/37853, 2007, A1. Location in patent: Page/Page column 23
[4] Tetrahedron, 2003, vol. 59, # 49, p. 9729 - 9742
[5] Patent: WO2006/71958, 2006, A1. Location in patent: Page/Page column 116

3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane Suppliers

Americas 1 China 146 Europe 1 India 3 Japan 1 United Kingdom 2 United States 18 Global 172

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

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View Lastest Price from 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane manufacturers

Changsha YuTeng New Materials Co., Ltd.

Product: 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane 114214-49-2
Price: US $0.00-0.00/g
Min. Order: 100g
Purity: 97%
Supply Ability: 500kg/M
Release date: 2024-11-07

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane 114214-49-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane 114214-49-2
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 2000tons
Release date: 2019-12-31

114214-49-2, 3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexaneRelated Search:

tert-butyl 6-oxo-3-aza-bicyclo[3.2.0]heptane-3-carboxylate (+/-)-BOC-ALPHA-PHOSPHONOGLYCINE TRIMETHYL ESTER 5-Bromoindole 4-CYANO-7-AZAINDOLE 4-FLUORO-2-HYDROXYBENZALDEHYDE 2-cyclopylcyclopropane-1-carboxylic acid (2R,5S)-tert-butyl 4-benzyl-2,5-diMethylpiperazine-1-carboxylate 5-Bromoindazole Pyrrolidine-3-carboxaMide hydrochloride 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 5-BROMO-2-METHYL-3-NITROPHENYL METHYLCARBOXYLATE 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester 1-METHYL-5-NITRO-1H-INDAZOLE 5-METHYL-4,5,6,7-TETRAHYDRO[1,3]THIAZOLO[5,4-C]PYRIDIN-2-AMINE rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl No Chinese name (6-Methylpyridazin-3-yl)MethanaMine dihydrochloride 1-Boc-4-(Hydroxymethyl)-4-methyl-piperidine

3-Boc-6-oxa-3-aza-bicyclo[3.1.0]hexane

6-Oxa-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

tert-butyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carbo

6-oxa-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester, 3-[(1,1-DiMethylethoxy)carbonyl]-6-oxa-3-azabicyclo[3.1.0]hexane-3

3-Boc-6-oxa-3-aza-bicyclo

6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

(1R,5S)-tert-butyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

6-Oxa-3-azabicyclo[3.1.0]hexane-3-carboxylic acid, 1,1-diMethylethyl ester

6-Oxa-3-azabicyclo[3.1.0]hexane, N-BOC protected

tert-Butyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate, 3-(tert-Butoxycarbonyl)-6-oxa-3-azabicyclo[3.1.0]hexane

Tert-butyl 6-oxa-3-azabicyclo[3.1.]hexane-3-carboxylate

3-Boc-6-Oxa-3-Aza-Bicyclo[3.1.0]Hexane(WX619109)

VOSA-011

N-Boc-6-Oxa-3-azabicyclo[3.1.0]hexane

3-Boc-6-oxa-3-azabicycL

o[3.1.0]hexane

ert-Butyl6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate

1-(tert-Butoxycarbonyl)-3,4-epoxypyrrolidine

1-Boc-3,4-epoxypyrrolidine

SWF-39

SW-39

114214-49-2

pharmacetical

Benzothiazoles,Thiazoles