ChemicalBook > CAS DataBase List > 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

Product Name
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
CAS No.
788136-89-0
Chemical Name
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
Synonyms
Gefitinib analog III;Gefitinib IMpurity VIII;Gefitinib Intermediate 6;Gefitinib interMediate VI;4-((3-Chloro-4-fluorophenyl);-7-methoxyquinazolin-6-yl acetate;O-Desmorpholinopropyl Gefitinib Acetate;4-(3-Chloro-4-fluorophenylamino)-7-methoxyquizolin-6-yl acetate;4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl ac...;4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
CBNumber
CB71503974
Molecular Formula
C17H13ClFN3O3
Formula Weight
361.75
MOL File
788136-89-0.mol
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4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate Property

Boiling point:
471.5±45.0 °C(Predicted)
Density 
1.425
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
5.22±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Matrix Scientific
Product number
091222
Product name
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
Purity
95+%
Packaging
250mg
Price
$521
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0037425
Product name
4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-METHOXY-6-QUINAZOLINOL 6-ACETATE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
Matrix Scientific
Product number
091222
Product name
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate
Purity
95+%
Packaging
1g
Price
$1143
Updated
2021/12/16
AvaChem
Product number
2461
Product name
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
Packaging
10g
Price
$850
Updated
2021/12/16
Arctom
Product number
AS097578
Product name
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ylacetate
Purity
95%
Packaging
250mg
Price
$6
Updated
2021/12/16
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4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate Chemical Properties,Usage,Production

Uses

4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl Acetate, is an impurity of Gefitinib (G304000), an antineoplastic.

Synthesis

367-21-5

230955-75-6

788136-89-0

General procedure for the synthesis of 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol acetate from 3-chloro-4-fluoroaniline and 6-acetoxy-4-chloro-7-methoxyquinazoline: at 65°C, AuCl (4.2 g, 18 mmol), 6-acetoxy-4-chloro-7-methoxyquinazoline (12.6 g, 50 mmol) and 3-chloro-4-fluoroaniline (12.3 g, 85 mmol) were dissolved in 50 mL of methanol for substitution reaction. After completion of the reaction, the reaction mixture was filtered. The filtrate was concentrated and washed with petroleum ether to afford 16.9 g of the intermediate 4-(3-chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol acetate in 93.4% yield and 99.91% purity.

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 2, p. 870 - 879
[2] Patent: CN105693630, 2016, A. Location in patent: Paragraph 0033
[3] Patent: CN106045980, 2016, A. Location in patent: Paragraph 0024; 0025; 0026
[4] Patent: CN108047209, 2018, A. Location in patent: Paragraph 0041; 0047; 0048
[5] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00195

4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate 788136-89-0
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-07-25
Nanjing Fred Technology Co., Ltd
Product
4-(3-Chloro-4-fluorophenyl-ami-no)-7-methoxyquinazolin-6-yl acetate 788136-89-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%(HPLC)
Supply Ability
5000kg
Release date
2023-12-13
Career Henan Chemical Co
Product
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate 788136-89-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
500kg
Release date
2018-08-16

788136-89-0, 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetateRelated Search:

Glycine Iminodiacetic acid Nitrilotriacetic acid Cellulose acetate Ammonium acetate Vinyl acetate 2-Methoxyethanol Ethyl acetate Goserelin acetate Ethyl 3-aminopropanoate hydrochloride Butyl acetate Ethyl methoxyacetate Sodium acetate Methoxyacetic acid Benzyl acetate 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol Magnesium acetate 4-(3-Chloropropyl)morpholine

  • 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol 6-acetate
  • 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
  • 6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, 6-acetate
  • Gefitinib interMediate VI
  • Gefitinib IMpurity VIII
  • acetic acid [4-(3-chloro-4-fluoroanilino)-7-methoxy-6-quinazolinyl] ester
  • 4-((3-Chloro-4-fluorophenyl)
  • -7-methoxyquinazolin-6-yl acetate
  • 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquizolin-6-yl acetate
  • 6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-, 6-aceta
  • O-Desmorpholinopropyl Gefitinib Acetate
  • Gefitinib Intermediate 6
  • 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl ac...
  • 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate
  • Gefitinib analog III
  • 788136-89-0
  • C17H13ClFN3O3
  • C18H15ClFN3O3