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D-Pantethine

Product Name
D-Pantethine
CAS No.
16816-67-4
Chemical Name
D-Pantethine
Synonyms
pantosin;Patethine;D-pantethine syrup;Lipodel;pantomin;PANTETHIN;Panthecin;pantetina;Dermorizin;LBF FACTOR
CBNumber
CB7155114
Molecular Formula
C22H42N4O8S2
Formula Weight
554.72
MOL File
16816-67-4.mol
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D-Pantethine Property

alpha 
D27 +13.5° (c = 3.75 in water)
Boiling point:
987.2±65.0 °C(Predicted)
Density 
1.1949 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
2-8°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
syrup
pka
12.71±0.20(Predicted)
color 
Crystals from MeOH/Me2CO
Stability:
Hygroscopic
InChI
InChI=1S/C22H42N4O8S2/c1-21(2,13-27)17(31)19(33)25-7-5-15(29)23-9-11-35-36-12-10-24-16(30)6-8-26-20(34)18(32)22(3,4)14-28/h17-18,27-28,31-32H,5-14H2,1-4H3,(H,23,29)(H,24,30)(H,25,33)(H,26,34)/t17-,18-/m0/s1
InChIKey
DJWYOLJPSHDSAL-ROUUACIJSA-N
SMILES
S(CCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO
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Safety

WGK Germany 
3
RTECS 
ES4392700
Toxicity
LD50 oral in rat: > 10gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P2125
Product name
D-Pantethine
Purity
analytical standard
Packaging
1g
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
P2125
Product name
D-Pantethine
Purity
analytical standard
Packaging
5g
Price
$396
Updated
2024/03/01
TRC
Product number
P205823
Product name
D-Pantethine
Packaging
50mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-4546
Product name
Pantethine
Purity
99.39%
Packaging
100mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-4546
Product name
Pantethine
Purity
99.39%
Packaging
500mg
Price
$84
Updated
2021/12/16
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D-Pantethine Chemical Properties,Usage,Production

Description

D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from D-pantothenic acid. It is known that the sulfhydryl group is the metabolically active part of the molecule. Coenzyme A is an essential cofactor in over 70 biological pathways, such as fatty acid oxidation, carbohydrate metabolism, and amino acid catabolism. Studies conducted in vitro suggest that D-Pantethine inhibits the activity of aldehyde dehydrogenase; however, related metabolites of the compound, such as Taurine (sc-202354), D-pantetheine, Coenzyme A, and D-pantothenate activate this enzyme.

Chemical Properties

Colorless to pale yellow, clear, viscous liquid

Originator

Atarone,Vinas

Uses

antilipemic

Definition

ChEBI: An organic disulfide that consists of two molecules of pantothenic acid linked by amide bonds to a cysteamine disulfide bridging group.

Manufacturing Process

To 11 g of hydrazine hydrate (85%) cooled in an ice bath are added 11.5 g of methyl d-pantothenate and the cold mixture is stirred vigorously. After the reaction takes place and the mixture is warmed to 30°C, it is allowed to stand at room temperature for two days, and then evaporated to dryness in vacuo at 50°C. The residue (14.7 g) of pantothenyl hydrazide is a clear glassy oil.
To 7.3 g of crude d-pantothenyl hydrazide dissolved in 21 ml of water and stirred in a beaker cooled on an ice bath is added sufficient. 6 N hydrochloric acid to shift the pH to 4. Then a solution of 1.7 g of sodium nitrite in 5 ml of water is added dropwise over a period of one hour, keeping the pH at 4 by additions of 6 N hydrochloric acid. After stirring for one-half hour, 2.8 g of bis(β-aminoethyl)disulfide dihydrochloride are added. The pH is then adjusted to 8.5 with 50% aqueous sodium hydroxide solution and the solution allowed to stir for one and one-half hours. It is then acidified to pH 7.5 and concentrated in vacuo to clear colorless viscous oil. The pure product can be isolated from this oil by the next method. The crude bis(Npantothenylamidoethyl)disulfide so obtained is purified by dissolving the crude reaction product in 45 ml of anhydrous n-butanol and pouring the resulting solution through a chromatograph column containing 272 g of activated carbon. The column is washed with n-butanol and fractions are collected from time to time and the fractions containing solids assaying about 25 to 40% pure bis(N-pantothenylamidoethyl)disulfide against Lactobacillus: helveticus 80 poured onto a chromatograph column containing 136 g of an alkaline earth aluminum silicate known commercially as Super -filtrol. The column is washed thoroughly with anhydrous n-butanol and the washings and main solution discarded. N-Butanol saturated with water is poured through the column to elute the bis(N-pantothenylamidoethyl)disulfide and the resulting solution evaporated to dryness in vacuum at low temperature to obtain the desired product in pure form.
Instead of pouring the anhydrous n-butanol solution onto the alkaline earth aluminum silicate chromatograph column, one can simply repeat the treatment with a carbon chromatograph column to obtain the pure product. In some instances, the first carbon treatment produces fractions containing pure bis(N-pantothenylamidoethyl)disulfide and in those cases it is, of course, not necessary to treat the fraction with alkaline earth aluminum silicate nor again with activated carbon.

Therapeutic Function

Growth factor, Antihyperlipidemic

Safety Profile

Moderately toxic by intravenous route. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

D-Pantethine Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Pantethine Suppliers

Hefei Topway Biotechnology Co.,Ltd
Tel
0551-65326752 14755135869
Fax
0086-551-65326751
Email
xxhasym@163.com
Country
China
ProdList
69
Advantage
60
Shaanxi Pioneer Biotech Co.,Ltd
Tel
029-029-84385017-8001-8001 18220517932
Fax
QQ3340501466
Email
sales5@pioneerbiotech.com
Country
China
ProdList
474
Advantage
58
Henan Evonik Biotechnology Co. LTD
Tel
17837010661
Email
2224986086@qq.com
Country
China
ProdList
4511
Advantage
58
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
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View Lastest Price from D-Pantethine manufacturers

Sinoway Industrial co., ltd.
Product
D-Pantethine 16816-67-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
50% up / Food grade
Supply Ability
20 tons
Release date
2021-08-17
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
Product
D-Pantethine 16816-67-4
Price
US $50.00-45.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
5500kg
Release date
2023-07-11
R&D Scientific Inc.
Product
D-pantethine 16816-67-4
Price
US $3500.00/Kg
Min. Order
1Kg
Purity
97
Supply Ability
500 Kg
Release date
2024-09-05

16816-67-4, D-PantethineRelated Search:


  • bis(pantothenamidoethyl)disulfide
  • butyramide,n,n’-(dithiobis(ethyleneiminocarbonylethylene))bis(2,4-dihydroxy-3,
  • d-(+)-3-dimethyl
  • d-bis(n-pantothenyl-beta-aminoethyl)disulfide
  • d-pantethineanhydrous
  • lbfdisulfide
  • PANTETHIN
  • Butanamide, N,N-dithiobis2,1-ethanediylimino(3-oxo-3,1-propanediyl)bis2,4-dihydroxy-3,3-dimethyl-, (2R,2R)-
  • N-[2-[2-[2-[3-[(2,4-dihydroxy-3,3-dimethyl-butanoyl)amino]propanoylamino]ethyldisulfanyl]ethylcarbamoyl]ethyl]-2,4-dihydroxy-3,3-dimethyl-butanamide
  • Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)- (9CI)
  • Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, [R-(R*,R*)]-
  • Butyramide, N,N'-[dithiobis(ethyleneiminocarbonylethylene)]bis[2,4-dihydroxy-3,3-dimethyl-, D-(+)- (8CI)
  • D-Bis-pantothenyl-b-aminoethyl disulfide
  • Lipodel
  • Panthecin
  • PANTETHINE BLEND 40% ACTIVE DRY POWDER
  • Bis(N-pantothenylamidoethyl) disulfide, LBF factor, Pantethein oxidized form
  • D-Pantethine hydrate
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  • Dermorizin
  • N,N'-[Dithiobis(ethyleneiminocarbonylethylene)]bis(2,4-dihydroxy-3,3-dimethylbutyramide)
  • D-Pantethine,Bis(N-pantothenylamidoethyl) disulfide, LBF factor, Pantethein oxidized form
  • Pantethine Liquid
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  • N,N’-[dithiobis(ethyleneiminocarbonylethylene)]bis(2,4-dihydroxy-3,3-dimethyl-,D-(+)-Butyramide
  • pantetina
  • pantomin
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  • (2R,2'R)-N,N'-(((disulfanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(3-oxopropane-3,1-diyl))bis(2,4-dihydroxy-3,3-dimethylbutanamide)
  • (2R,2'R)-N,N'-(((Disulfanediylbis(ethane-2,1-diyl))bis(azanediyl))bis(3-oxopropane-3,1-diyl))bis(2,4-dihydroxy-3,3-dimethylbutanamide)
  • 16816-67-4
  • C22H42N4O8S2
  • PA - PEN
  • Analytical Chromatography Product Catalog
  • Analytical Standards
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  • Inhibitors