ChemicalBook > CAS DataBase List > 1H-Benzimidazole-4-carboxylic acid

1H-Benzimidazole-4-carboxylic acid

Product Name
1H-Benzimidazole-4-carboxylic acid
CAS No.
46006-36-4
Chemical Name
1H-Benzimidazole-4-carboxylic acid
Synonyms
4-Carboxy-1H-benzimidazole;Benzimidazole-4-carboxylicacid;4-Benzimidazolecarboxylic acid;1H-BENZIMIDAZOLE-4-CARBOXYLIC ACID;1,3-Benzodiazole-4-carboxylic acid;1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID;benzimidazole-4-carboxylic acid HCl;1H-Benzimidazole-4-carboxylicacid97%;1H-benzo[d]imidazol-7-carboxylic acid;1H-1,3-benzodiazole-4-carboxylic acid
CBNumber
CB7164877
Molecular Formula
C8H6N2O2
Formula Weight
162.15
MOL File
46006-36-4.mol
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1H-Benzimidazole-4-carboxylic acid Property

Melting point:
>300 °C
Boiling point:
542.5±23.0 °C(Predicted)
Density 
1.506±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
0.17±0.10(Predicted)
Appearance
Off-white to light brown Solid
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36-51
Safety Statements 
53-26-61
RIDADR 
UN 3077 9 / PGIII
HazardClass 
IRRITANT
HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B197883
Product name
1H-Benzimidazole-4-carboxylicAcid
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
B197883
Product name
1H-Benzimidazole-4-carboxylicAcid
Packaging
500mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR6307
Product name
1H-Benzimidazole-4-carboxylicacid
Purity
97%
Packaging
250mg
Price
$37
Updated
2021/12/16
SynQuest Laboratories
Product number
4H21-1-C7
Product name
1H-Benzimidazole-4-carboxylic acid
Purity
97%
Packaging
250mg
Price
$40
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B11086
Product name
1H-Benzoimidazole-4-carboxylicacid
Purity
94%
Packaging
1g
Price
$45
Updated
2021/12/16
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1H-Benzimidazole-4-carboxylic acid Chemical Properties,Usage,Production

Synthesis

64-18-6

603-81-6

46006-36-4

To a 4M hydrochloric acid (20 mL) solution of formic acid (0.75 mL, 20.0 mmol) was added 2,3-diaminobenzoic acid (1.00 g, 6.6 mmol). The reaction mixture was heated at reflux temperature for 2 h and subsequently cooled to room temperature. The resulting pink precipitate was separated by filtration and dissolved in hot methanol. Decolorization was carried out by adding activated carbon and stirring for 10 min. The suspension was filtered and the solvent was evaporated under reduced pressure to afford benzimidazole-7-carboxylic acid (0.542 g, 51% yield) as white crystals with a melting point of 266-268 °C. The structure of the product was analyzed by 1H NMR (300 MHz, DMSO-d6) δ 9.64 (s, 1H), 8.11 (dd, J = 8.2, 0.9 Hz, 1H), 8.07 (dd, J = 7.6, 0.9 Hz, 1H), 7.65 (dd, J = 8.2, 7.6 Hz, 1H) and 13C NMR (75 MHz, DMSO-d6 ) δ 265.2, 142.0, 132.3, 129.3, 127.6, 125.6, 119.7, 117.6 confirmed.

References

[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 22, p. 4084 - 4097
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[3] Chemische Berichte, 1901, vol. 34, p. 905
[4] Patent: WO2018/42362, 2018, A1. Location in patent: Page/Page column 50

1H-Benzimidazole-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-Benzimidazole-4-carboxylic acid manufacturers

Career Henan Chemical Co
Product
1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID 46006-36-4
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-03-23

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