1H-Benzimidazole-4-carboxylic acid
- Product Name
- 1H-Benzimidazole-4-carboxylic acid
- CAS No.
- 46006-36-4
- Chemical Name
- 1H-Benzimidazole-4-carboxylic acid
- Synonyms
- 4-Carboxy-1H-benzimidazole;Benzimidazole-4-carboxylicacid;4-Benzimidazolecarboxylic acid;1H-BENZIMIDAZOLE-4-CARBOXYLIC ACID;1,3-Benzodiazole-4-carboxylic acid;1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID;benzimidazole-4-carboxylic acid HCl;1H-Benzimidazole-4-carboxylicacid97%;1H-benzo[d]imidazol-7-carboxylic acid;1H-1,3-benzodiazole-4-carboxylic acid
- CBNumber
- CB7164877
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 46006-36-4.mol
1H-Benzimidazole-4-carboxylic acid Property
- Melting point:
- >300 °C
- Boiling point:
- 542.5±23.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.17±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
N-Bromosuccinimide Price
- Product number
- B197883
- Product name
- 1H-Benzimidazole-4-carboxylicAcid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B197883
- Product name
- 1H-Benzimidazole-4-carboxylicAcid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR6307
- Product name
- 1H-Benzimidazole-4-carboxylicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $37
- Updated
- 2021/12/16
- Product number
- 4H21-1-C7
- Product name
- 1H-Benzimidazole-4-carboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- B11086
- Product name
- 1H-Benzoimidazole-4-carboxylicacid
- Purity
- 94%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
1H-Benzimidazole-4-carboxylic acid Chemical Properties,Usage,Production
Synthesis
64-18-6
603-81-6
46006-36-4
To a 4M hydrochloric acid (20 mL) solution of formic acid (0.75 mL, 20.0 mmol) was added 2,3-diaminobenzoic acid (1.00 g, 6.6 mmol). The reaction mixture was heated at reflux temperature for 2 h and subsequently cooled to room temperature. The resulting pink precipitate was separated by filtration and dissolved in hot methanol. Decolorization was carried out by adding activated carbon and stirring for 10 min. The suspension was filtered and the solvent was evaporated under reduced pressure to afford benzimidazole-7-carboxylic acid (0.542 g, 51% yield) as white crystals with a melting point of 266-268 °C. The structure of the product was analyzed by 1H NMR (300 MHz, DMSO-d6) δ 9.64 (s, 1H), 8.11 (dd, J = 8.2, 0.9 Hz, 1H), 8.07 (dd, J = 7.6, 0.9 Hz, 1H), 7.65 (dd, J = 8.2, 7.6 Hz, 1H) and 13C NMR (75 MHz, DMSO-d6 ) δ 265.2, 142.0, 132.3, 129.3, 127.6, 125.6, 119.7, 117.6 confirmed.
References
[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 22, p. 4084 - 4097
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 14, p. 3933 - 3937
[3] Chemische Berichte, 1901, vol. 34, p. 905
[4] Patent: WO2018/42362, 2018, A1. Location in patent: Page/Page column 50
1H-Benzimidazole-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Benzimidazole-4-carboxylic acid Suppliers
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- Country
- Russia
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View Lastest Price from 1H-Benzimidazole-4-carboxylic acid manufacturers
- Product
- 1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID 46006-36-4
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-03-23