2-(chloromethyl)-4-methylquinazoline

Product Name: 2-(chloromethyl)-4-methylquinazoline
CAS No.: 109113-72-6
Chemical Name: 2-(chloromethyl)-4-methylquinazoline
Synonyms: Quinazoline,2-(chloroMethyl)-4-Methyl-;Linaint-I;Linagliptin INT3;Linagliptin Impurity 67;Linagliptin interMediate A;CHLOROMETHYL)-4-METHYLQUINAZOLINE;2-chloroMethyl-4-Methyl quinaoline;2-(chloromethyl)-4-methylquizoline;Linagliptin 2-Chloromethyl Impurity;2-(chloromethyl)-4-methylquinazolin
CBNumber: CB71648970
Molecular Formula: C10H9ClN2
Formula Weight: 192.64
MOL File: 109113-72-6.mol

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2-(chloromethyl)-4-methylquinazoline Property

Melting point:: 61.0 to 65.0 °C
Boiling point:: 240.0±32.0 °C(Predicted)
Density: 1.251
vapor pressure: 0Pa at 20℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: powder to crystal
pka: 1.86±0.50(Predicted)
color: Light yellow to Yellow to Orange
Water Solubility: 3.11g/L at 20℃
λmax: 318nm(EtOH)(lit.)
InChIKey: UHCUBOJGMLASBY-UHFFFAOYSA-N
LogP: 1.9 at 25℃

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Safety

RIDADR: 3261
HazardClass: 8
PackingGroup: III
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2928
Product name: 2-(Chloromethyl)-4-methylquinazoline
Purity: >98.0%(GC)
Packaging: 1g
Price: $78
Updated: 2024/03/01

TCI Chemical

Product number: C2928
Product name: 2-(Chloromethyl)-4-methylquinazoline
Purity: >98.0%(GC)
Packaging: 200mg
Price: $28
Updated: 2024/03/01

TRC

Product number: C369850
Product name: 2-(Chloromethyl)-4-methylquinazoline
Packaging: 2.5g
Price: $95
Updated: 2021/12/16

TRC

Product number: C369850
Product name: 2-(Chloromethyl)-4-methylquinazoline
Packaging: 5g
Price: $155
Updated: 2021/12/16

TRC

Product number: C369850
Product name: 2-(Chloromethyl)-4-methylquinazoline
Packaging: 25g
Price: $400
Updated: 2021/12/16

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2-(chloromethyl)-4-methylquinazoline Chemical Properties,Usage,Production

Chemical Properties

White to yellow powder

Uses

2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 23, p. 1263, 1986 DOI: 10.1002/jhet.5570230458

Flammability and Explosibility

Not classified

Synthesis

Into a 500ml reaction flask, add o-aminoacetophenone, chloroacetonitrile, 1,4-dioxane, and N-methyl-3(3-sulfopropyl)imidazolium hydrogen sulfate prepared above. Stir to dissolve, cool the reaction system to 8°C, and dropwise add hydrochloric acid to the reaction system. The reaction temperature was kept unchanged during the dropwise addition. After that, the reaction was continued at 8°C for 18 hours to complete the reaction process. After the reaction, ammonia water (the concentration of ammonia water was 10wt%) at 5°C was added to the reaction system. After stirring and crystallizing at 5 for 30 minutes, filter to obtain a filter cake, washing the filter cake with water. Recrystallized with 200ml of dichloromethane to obtain 2-(chloromethyl)-4-methylquinazoline. yield: 85.14%

2-(chloromethyl)-4-methylquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(chloromethyl)-4-methylquinazoline Suppliers

Americas 1 China 374 Europe 1 India 79 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 3 United States 13 Global 475

Emei shan Hongsheng Pharmaceutical Co., LTD

Tel: 0833-6186272、6186278、6170066 18990613291
Fax: 0833-5590359
Email: sales@hongshengpharm.com
Country: China
ProdList: 58
Advantage: 60

Shandong Sihuan Pharmaceutical Co., Ltd.

Tel: 0531-88993983 13065008173
Fax: QQ:787658403
Email: nora.zhang@sdsihuanpharm.com
Country: China
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Shijiazhuang Qiyue Chemical Co. LTD

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Email: sjzqiyuekeji@163.com
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Suzhou lipin Chemical Co., Ltd

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Jinan Dexinjia Bio&Tech Co., Ltd

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ShenZhen H&D Pharmaceutical Technology Co., LTD

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Beijing Huikang Boyuan Chemical Tech Co., Ltd

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Fax: 010-68882204
Email: sales@huikangchem.com
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
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JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
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View Lastest Price from 2-(chloromethyl)-4-methylquinazoline manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 2-(Chloromethyl)-4-methylquinazoline 109113-72-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: hundreds of kg
Release date: 2022-02-17

PNP Biotech Co. Ltd

Product: 2-(chloromethyl)-4-methylquinazoline 109113-72-6
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%-99%
Supply Ability: Inquiry
Release date: 2022-10-19

Nanjing Fred Technology Co., Ltd

Product: 2-(chloromethyl)-4-methylquinazoline 109113-72-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1 ton
Release date: 2023-11-17

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