Methyl bromoacetate Property

Melting point:

-50°C

Boiling point:

51-52 °C/15 mmHg (lit.)

Density 

1.616 g/mL at 25 °C (lit.)

vapor pressure 

18 hPa (50 °C)

refractive index 

n20/D 1.458(lit.)

Flash point:

145 °F

storage temp. 

Store below +30°C.

form 

Liquid

color 

Clear colorless to slightly yellow

Specific Gravity

1.416

Water Solubility 

Miscible with methanol, ether and acetone. Slightly miscible with water

FreezingPoint 

<-50℃

BRN 

506256

LogP

0.71 at 25℃

CAS DataBase Reference

96-32-2(CAS DataBase Reference)

NIST Chemistry Reference

Acetic acid, bromo-, methyl ester(96-32-2)

EPA Substance Registry System

Acetic acid, bromo-, methyl ester (96-32-2)

Safety

Hazard Codes 

T,Xi,F

Risk Statements 

25-34-37-23/24/25-40-36/37/38-38

Safety Statements 

26-36/37/39-45-28A-36-16

RIDADR 

UN 2643 6.1/PG 2

WGK Germany 

3

RTECS 

AF6300000

F 

19

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29159080

Hazardous Substances Data

96-32-2(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Methyl bromoacetate Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Methyl bromoacetate was used in the synthesis of novel coumarins. It was also employed in the synthesis of cis-cyclopropanes

Uses

Methyl bromoacetate is used in the synthesis of coumarins and cis-cyclopropanes. It reacts with the conjugate base of (methylmethoxycarbene)pentacarbonylchromium(0) to prepare alkylated carbene complexes. Further, it is used to make vitamins and pharmaceuticals.

Application

Methyl Bromoacetate is an organic building block that has been used as a reactant in the preparation of isoquinolinone indole acetic acid derivatives as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

General Description

A colorless to straw-colored liquid with a sharp penetrating odor. Denser than water and soluble in water. Severly irritates skin and eyes. Toxic by ingestion and inhalation. Used to make vitamins and pharmaceuticals.

Air & Water Reactions

Highly flammable. Soluble in water.

Reactivity Profile

Methyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Vapor is strong irritant to eyes.

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Safety Profile

Poison by intravenous route. When heated to decomposition it emits toxic fumes of Br-. See also ESTERS.