6-Bromo-4-chloroquinazoline

Product Name: 6-Bromo-4-chloroquinazoline
CAS No.: 38267-96-8
Chemical Name: 6-Bromo-4-chloroquinazoline
Synonyms: 6-BROMO-4-CHLOROQUINAZOLINE;4-Chloro-6-bromoquinazoline;6-Bromo-4-chloroquinazoli...;6-BROMO-4-CHLOROQUINAZOLINE, 95+%;6-Bromo-4-chloro-quinazoline hydrochloride;4-Chloro-6-bromoquinazoline, CAS 38267-96-8;6-Bromo-4-chloroquinazoline ISO 9001：2015 REACH
CBNumber: CB7199336
Molecular Formula: C8H4BrClN2
Formula Weight: 243.49
MOL File: 38267-96-8.mol

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6-Bromo-4-chloroquinazoline Property

Melting point:: 160-163 °C
Boiling point:: 339.7±22.0 °C(Predicted)
Density: 1.763
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.07±0.30(Predicted)
Appearance: White to yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684723
Product name: 6-Bromo-4-chloroquinazoline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B684723
Product name: 6-Bromo-4-chloroquinazoline
Packaging: 500mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-2Q
Product name: 6-Bromo-4-chloroquinazoline
Purity: 97.0%
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB32832
Product name: 6-Bromo-4-chloroquinazoline
Packaging: 2g
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 049079
Product name: 4-Chloro-6-bromoquinazoline
Packaging: 250mg
Price: $10
Updated: 2021/12/16

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6-Bromo-4-chloroquinazoline Chemical Properties,Usage,Production

Synthesis

32084-59-6

38267-96-8

General procedure for the synthesis of 4-chloro-6-bromoquinazoline from 6-bromo-3H-quinazolin-4-one (20 g, 89 mmol): 6-bromo-3H-quinazolin-4-one was suspended in 140 mL of phosphorus oxychloride (POCl3), and the reaction was stirred for 3 hr at 140 °C. After completion of the reaction, the reaction mixture was concentrated under vacuum and the residue was dissolved in 500 mL of dichloromethane (CH2Cl2). The reaction solution was neutralized with 200 g of solid sodium bicarbonate (NaHCO3), filtered, and the filtrate was evaporated under vacuum to afford 4-chloro-6-bromoquinazoline (21 g, 95% yield) as a beige solid. The product was characterized by 1H-NMR (400 MHz, CDCl3, 298 K): δ 7.98 (d, 1H), 8.09 (d, 1H), 8.5 (s, 1H), 9.1 (s, 1H). Mass spectrometry (MS) analysis showed [M + 1]+ m/z 243.0-244.9, retention time (Rt) = 1.24 min.

References

[1] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 57
[2] Patent: WO2013/88404, 2013, A1. Location in patent: Page/Page column 186
[3] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0974-0975
[4] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 8, p. 762 - 767
[5] Patent: TWI557109, 2016, B. Location in patent: Page/Page column 48; 49; 83

6-Bromo-4-chloroquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromo-4-chloroquinazoline Suppliers

China 170 Germany 2 India 3 Ukraine 1 United Kingdom 3 United States 24 Global 203

J & K SCIENTIFIC LTD.

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Energy Chemical

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Shanghai Hanhong Scientific Co.,Ltd.

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Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
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View Lastest Price from 6-Bromo-4-chloroquinazoline manufacturers

Career Henan Chemical Co

Product: 6-Bromo-4-chloroquinazoline 38267-96-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-09

38267-96-8, 6-Bromo-4-chloroquinazolineRelated Search:

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6-BROMO-4-CHLOROQUINAZOLINE, 95+%

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6-Bromo-4-chloro-quinazoline hydrochloride

6-BROMO-4-CHLOROQUINAZOLINE

6-Bromo-4-chloroquinazoli...

6-Bromo-4-chloroquinazoline ISO 9001：2015 REACH

4-Chloro-6-bromoquinazoline, CAS 38267-96-8

38267-96-8

C8H4BrClN2

CHIRAL CHEMICALS