ChemicalBook > CAS DataBase List > Tolperisone hydrochloride

Tolperisone hydrochloride

Product Name
Tolperisone hydrochloride
CAS No.
3644-61-9
Chemical Name
Tolperisone hydrochloride
Synonyms
Abbsa;n-553;Isocalm;Kineorl;muscalm;Atmosgen;Minacalm;midocalm;mydocalm;Arantoick
CBNumber
CB7200340
Molecular Formula
C16H24ClNO
Formula Weight
281.82
MOL File
3644-61-9.mol
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Tolperisone hydrochloride Property

Melting point:
181-183°C
storage temp. 
room temp
solubility 
H2O: >20mg/mL
form 
solid
color 
white
PH
pH(50g/l, 25℃) : 4.5～5.5
Water Solubility 
almost transparency
Merck 
14,9522
CAS DataBase Reference
3644-61-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-52/53-36/37/38
Safety Statements 
26-36-45-61-36/37-37/39
WGK Germany 
3
RTECS 
UH1575500
Toxicity
LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3577
Product name
Tolperisone hydrochloride
Purity
≥98% (HPLC), solid
Packaging
50mg
Price
$144
Updated
2024/03/01
Sigma-Aldrich
Product number
T3577
Product name
Tolperisone hydrochloride
Purity
≥98% (HPLC), solid
Packaging
250mg
Price
$442
Updated
2024/03/01
TCI Chemical
Product number
T1319
Product name
Tolperisone Hydrochloride
Purity
>99.0%(HPLC)(T)
Packaging
25g
Price
$75
Updated
2021/12/16
Cayman Chemical
Product number
26078
Product name
Tolperisone (hydrochloride)
Packaging
1g
Price
$363
Updated
2024/03/01
Cayman Chemical
Product number
26078
Product name
Tolperisone (hydrochloride)
Packaging
5g
Price
$1085
Updated
2024/03/01
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Tolperisone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Tolperisone hydrochloride,Shanghai Abochem Chemical Co.

Uses

Tolperisone hydrochloride can be used as a muscle relaxant.

Definition

ChEBI: Tolperisone hydrochloride is an aromatic ketone.

Manufacturing Process

To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.

Therapeutic Function

Muscle relaxant, Vasodilator

Biochem/physiol Actions

Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.

Tolperisone hydrochloride Preparation Products And Raw materials

Raw materials

Piperidine 4'-Methylpropiophenone

Preparation Products

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Tolperisone hydrochloride Suppliers

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View Lastest Price from Tolperisone hydrochloride manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Tolperisone Hydrochloride 3644-61-9
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
50kg/Month
Release date
2024-10-09
Hebei Weibang Biotechnology Co., Ltd
Product
Tolperisone Hydrochloride 3644-61-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-11
airuikechemical co., ltd.
Product
Tolperisone hydrochloride 3644-61-9
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20tons
Release date
2024-04-07

3644-61-9, Tolperisone hydrochlorideRelated Search:

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  • 3644-61-9
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