Tolperisone hydrochloride

Product Name: Tolperisone hydrochloride
CAS No.: 3644-61-9
Chemical Name: Tolperisone hydrochloride
Synonyms: Abbsa;n-553;Isocalm;Kineorl;muscalm;Atmosgen;Minacalm;midocalm;mydocalm;Arantoick
CBNumber: CB7200340
Molecular Formula: C16H24ClNO
Formula Weight: 281.82
MOL File: 3644-61-9.mol

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Tolperisone hydrochloride Property

Melting point:: 181-183°C
storage temp.: room temp
solubility: H2O: >20mg/mL
form: solid
color: white
PH: pH(50g/l, 25℃) : 4.5～5.5
Water Solubility: almost transparency
Merck: 14,9522
CAS DataBase Reference: 3644-61-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 20/21/22-52/53-36/37/38
Safety Statements: 26-36-45-61-36/37-37/39
WGK Germany: 3
RTECS: UH1575500
Toxicity: LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3577
Product name: Tolperisone hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 50mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: T3577
Product name: Tolperisone hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 250mg
Price: $442
Updated: 2024/03/01

TCI Chemical

Product number: T1319
Product name: Tolperisone Hydrochloride
Purity: >99.0%(HPLC)(T)
Packaging: 25g
Price: $75
Updated: 2021/12/16

Cayman Chemical

Product number: 26078
Product name: Tolperisone (hydrochloride)
Packaging: 1g
Price: $363
Updated: 2024/03/01

Cayman Chemical

Product number: 26078
Product name: Tolperisone (hydrochloride)
Packaging: 5g
Price: $1085
Updated: 2024/03/01

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Tolperisone hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Tolperisone hydrochloride,Shanghai Abochem Chemical Co.

Uses

Tolperisone hydrochloride can be used as a muscle relaxant.

Definition

ChEBI: Tolperisone hydrochloride is an aromatic ketone.

Manufacturing Process

To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added an excess of thionyl chloride and the reaction mixture refluxed until completed. It was then taken to dryness under reduced pressure and the residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate. An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone was purified by distilling the base (boiling point 106-107°C/1 mm) and reconverting to the hydrochloride, melting point 216-217°C.

Therapeutic Function

Muscle relaxant, Vasodilator

Biochem/physiol Actions

Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem.

Tolperisone hydrochloride Preparation Products And Raw materials

Raw materials

Piperidine 4'-Methylpropiophenone

Preparation Products

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Tolperisone hydrochloride Suppliers

Belgium 1 Canada 4 China 199 Europe 1 France 3 Germany 6 India 38 Japan 4 South Korea 3 Switzerland 2 United Kingdom 9 United States 38 Venezuela 1 Global 309

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28398
Advantage: 80

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View Lastest Price from Tolperisone hydrochloride manufacturers

Zibo Wei Bin Import & Export Trade Co. Ltd.

Product: Tolperisone hydrochloride 3644-61-9
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1t
Release date: 2023-07-11

airuikechemical co., ltd.

Product: Tolperisone hydrochloride 3644-61-9
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 20tons
Release date: 2024-04-07

Shanghai Affida new material science and technology center

Product: Tolperisone Hydrochloride 3644-61-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 10 tons
Release date: 2024-03-19

3644-61-9, Tolperisone hydrochlorideRelated Search:

M-METHYLPROPIOPHENONE Tolperisone Impurity A Tolperisone Impurity B Paroxetine hydrochloride Tolperisone Impurity C ETHYL-O-TOLYL KETONE 4'-Methylacetophenone 4'-Methylpropiophenone 1-(4-Ethylphenyl)-2-methyl-2-propen-1-one 1-(4-Ethylphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride 2-methyl-1-phenyl-3-(1-piperidyl)propan-1-one 1-Propanone, 1-(2-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride (1:1) Eperisone Impurity 6(Hydrochloride) 3-METHYLAMINO-1-PHENYLACETONE HYDROCHLORIDE Eperisone hydrochloride 3-(diethylamino)propiophenone Tolperisone hydrochloride Tolperisone

1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride

LABOTEST-BB LT00772344

2-Methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one hydrochloride

Tolperizone hydrochloride

4'-METHYL-2-(1-PIPERIDINYLMETHYL)-PROPIOPHENONE HCL

4'-methyl-2-(1-piperidinylmethyl)-propiophenone hydrochloride

2,4'-DIMETHYL-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE

2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride

TOLPERISONE HCL

TOLPERISONE HYDROCHLORIDE

1-Piperidino-2-methyl-3-(4-methylphenyl)propan-3-one hydrochloride

1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI)

Abbsa

Arantoick

Atmosgen

Besnoline

Isocalm

Kineorl

Menopatol

Metosomin

Minacalm

Naismeritin

Propiophenone, 2,4'-dimethyl-3-piperidino-, hydrochloride (7CI, 8CI)

Tolisartine

2-methyl-1-(4-methylphenyl)-3-piperidin-1-yl-propan-1-one hydrochloride

2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydrochloride

2-Methyl-1-(4-Methylphenyl)-3-(1-piperidinyl)-1-propanone Hydrochloride

1-Propanone, 2-Methyl-1-(4-Methylphenyl)-3-(1-piperidinyl)-, hydrochloride (1:1)

2,4’-dimethyl-3-piperidino-propiophenonhydrochloride

2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanonhydrochloride

2-methyl-3-piperidino-1-p-tolylpropan-1-onehydrochloride

midocalm

muscalm

mydocalm

n-553

Tolperisone hydrochloride, >=99%

Tolperisone Hydrochloridum

Topiperone hydrochloride

Tolperisonce hcl

Tolperisone hydrochloride USP/EP/BP

Tolperisone HCl (AV 650)

Tolperisone HydrochlorideQ: What is Tolperisone Hydrochloride Q: What is the CAS Number of Tolperisone Hydrochloride Q: What is the storage condition of Tolperisone Hydrochloride Q: What are the applications of Tolperisone Hydrochloride

TIANFU CHEM Tolperisone hydrochloride

Toperidone hydrochloride

Eperisone Impurity 18

Eperisone Impurity 2 HCl

Tolperisone HCl Reference Standard

3644-61-9

3944-61-9

3644-61-8

C16H23NOHCl

C16H23NOHClC16H24ClNO

C16H24NOCl

Intermediates & Fine Chemicals

Pharmaceuticals