ETHYL 2-AMINO-5-BROMONICOTINATE

Product Name: ETHYL 2-AMINO-5-BROMONICOTINATE
CAS No.: 433226-06-3
Chemical Name: ETHYL 2-AMINO-5-BROMONICOTINATE
Synonyms: ETHYL 2-AMINO-5-BROMONICOTINATE;Ethyl 2-amino-5-bromopyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-aMino-5-broMo-, ethyl ester;Ethyl 2-amino-5-bromopyridine-3-carboxylate, 2-Amino-5-bromo-3-(ethoxycarbonyl)pyridine
CBNumber: CB7203169
Molecular Formula: C8H9BrN2O2
Formula Weight: 245.07
MOL File: Mol file

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ETHYL 2-AMINO-5-BROMONICOTINATE Property

Melting point:: 139-141°
Boiling point:: 290.6±35.0 °C(Predicted)
Density: 1.575±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 2.59±0.49(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: E899388
Product name: Ethyl2-amino-5-bromonicotinate
Packaging: 250mg
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-0041495
Product name: Ethyl2-amino-5-bromonicotinate
Purity: 99.14%
Packaging: 5g
Price: $88
Updated: 2021/12/16

Matrix Scientific

Product number: 042882
Product name: Ethyl 2-amino-5-bromonicotinate
Purity: 95+%
Packaging: 1g
Price: $48
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-9-X3
Product name: Ethyl 2-amino-5-bromonicotinate
Packaging: 1g
Price: $128
Updated: 2021/12/16

Matrix Scientific

Product number: 042882
Product name: Ethyl 2-amino-5-bromonicotinate
Purity: 95+%
Packaging: 5g
Price: $146
Updated: 2021/12/16

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ETHYL 2-AMINO-5-BROMONICOTINATE Chemical Properties,Usage,Production

Synthesis

13362-26-0

433226-06-3

General procedure for the synthesis of ethyl 2-amino-5-bromonicotinate from ethyl 2-aminonicotinate: to a stirred solution of ethyl 2-aminonicotinate (15 g; 90.36 mmol; 1 eq.) in anhydrous THF (150 mL) was added N-bromosuccinimide (NBS) (16 g; 90.36 mmol; 1 eq.) in batches at 0 °C. The resulting mixture was stirred at 23 °C for 18 hours. Upon completion of the reaction, the mixture was poured into ice-cold saturated aqueous NaHCO3 solution and the organic components were extracted with ethyl acetate (3 x 200 mL). The combined organic layers were washed with brine solution, dried over anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure to afford ethyl 2-amino-5-bromonicotinate (22 g, 100%) as an off-white solid. The product was confirmed by 1H NMR (DMSO-d6): δ 8.29 (d, 1H, J = 3Hz), 8.12 (d, 1H, J = 2Hz), 7.31 (s, 2H), 4.29 (q, 2H, J = 7Hz), 1.30 (t, 3H, J = 7Hz).The LCMS analysis resulted in: m/z = 245.0 [M + H]+, 247.0 [M + 2H]+, retention time (RT) = 3.34 min (program P1, column W).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0239; 0242; 0243
[2] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 236 - 246
[3] Patent: CN104402881, 2016, B. Location in patent: Paragraph 0022; 0023
[4] Patent: WO2007/67416, 2007, A2. Location in patent: Page/Page column 64; 134

ETHYL 2-AMINO-5-BROMONICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 2-AMINO-5-BROMONICOTINATE Suppliers

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433226-06-3, ETHYL 2-AMINO-5-BROMONICOTINATERelated Search:

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ETHYL 2-AMINO-5-BROMONICOTINATE

Ethyl 2-amino-5-bromopyridine-3-carboxylate

Ethyl 2-amino-5-bromopyridine-3-carboxylate, 2-Amino-5-bromo-3-(ethoxycarbonyl)pyridine

3-Pyridinecarboxylic acid, 2-aMino-5-broMo-, ethyl ester

433226-06-3

139-141