ChemicalBook > CAS DataBase List > 2-Chloropyridine-5-carbaldehyde
2-Chloropyridine-5-carbaldehyde
- Product Name
- 2-Chloropyridine-5-carbaldehyde
- CAS No.
- 23100-12-1
- Chemical Name
- 2-Chloropyridine-5-carbaldehyde
- Synonyms
- 6-CHLORONICOTINALDEHYDE;6-CHLORO-PYRIDINE-3-CARBALDEHYDE;TIMTEC-BB SBB004157;2-Chloropyridine-5-c;oropyridine-5-carbaL;6-Chloronicotildehyde;2-CHLORO-5-FORMYLPYRIDINE;6-Chloronicotinaldehyde 97%;6-CHLORO-PYRIDIN-3-CARBALDEHYDE;2-CHLOROPYRIDINE-5-CARBALDEHYDE
- CBNumber
- CB7205204
- Molecular Formula
- C6H4ClNO
- Formula Weight
- 141.56
- MOL File
- 23100-12-1.mol
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2-Chloropyridine-5-carbaldehyde Property
- Melting point:
- 77-81 °C(lit.)
- Boiling point:
- 117-119 °C(Press: 5 Torr)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -1.85±0.10(Predicted)
- form
- Crystalline Powder
- color
- White to yellow
- Water Solubility
- Soluble in water.
- InChI
- InChI=1S/C6H4ClNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
- InChIKey
- AFWWKZCPPRPDQK-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=CC=C1C=O
- CAS DataBase Reference
- 23100-12-1(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 596175
- Product name
- 6-Chloropyridine-3-carboxaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $39.9
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 596175
- Product name
- 6-Chloropyridine-3-carboxaldehyde
- Purity
- 96%
- Packaging
- 5g
- Price
- $144
- Updated
- 2023/06/20
TCI Chemical
- Product number
- C2519
- Product name
- 6-Chloro-3-pyridinecarboxaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 1g
- Price
- $44
- Updated
- 2025/07/31
TCI Chemical
- Product number
- C2519
- Product name
- 6-Chloro-3-pyridinecarboxaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $136
- Updated
- 2025/07/31
TRC
- Product number
- C380528
- Product name
- 6-Chloronicotinaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
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2-Chloropyridine-5-carbaldehyde Chemical Properties,Usage,Production
Chemical Properties
Off-white crystal
Uses
2-Chloropyridine-5-carboxaldehyde is used as pharmaceutical intermediates
Synthesis
21543-49-7
23100-12-1
The general procedure for the synthesis of 6-chloropyridine-3-carbaldehyde according to Lee et al. was as follows: oxalyl chloride (3.81 g, 30.0 mmol, 3.0 equiv.) was dissolved in dry dichloromethane (35 mL) at -78 °C (dry ice/acetone bath). Dimethyl sulfoxide (DMSO, 46.9 g, 0.60 mol, 60.0 eq.) was slowly added dropwise under stirring and stirring was continued for 30 min at -78 °C. Subsequently, 2-chloro-5-hydroxymethylpyridine (1.44 g, 10.0 mmol, 1.00 eq.) was dissolved in dichloromethane (10 mL) and added slowly dropwise via syringe to the cooled reaction mixture. After the reaction mixture was stirred at -78 °C for 40 min, triethylamine (NEt3, 91.9 g, 0.90 mol, 90.0 eq.) was added at a rate of 2.0 mL/min. Stirring was continued at -78 °C for 1 hour, then brought to room temperature and stirred for 1.5 hours. After completion of the reaction, the reaction mixture was diluted with ether (60 mL) and the organic phase was washed sequentially with saturated aqueous sodium bicarbonate (2 x 30 mL), 1M aqueous potassium bisulfate (60 mL) and saturated aqueous sodium bicarbonate (30 mL). After separation of the organic phase, it was dried with anhydrous sodium sulfate, filtered to remove solids, and concentrated under reduced pressure to remove solvent. Finally, it was purified by silica gel column chromatography (n-pentane/ethyl acetate/triethylamine=200/100/6) to afford the light yellow solid product 6-chloropyridine-3-carbaldehyde (1.35 g, 96% yield).
References
[1] Chemical Communications, 1999, # 18, p. 1907 - 1908
[2] Organic Letters, 2005, vol. 7, # 14, p. 2965 - 2967
[3] Electrochimica Acta, 2014, vol. 140, p. 101 - 107
[4] Chemistry - A European Journal, 2016, vol. 22, # 15, p. 5319 - 5326
[5] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 10, p. 1253 - 1255
2-Chloropyridine-5-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloropyridine-5-carbaldehyde manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 2-Chloropyridine-5-carbaldehyde 23100-12-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-23
Shaanxi Dideu New Materials Co. Ltd
- Product
- 2-Chloropyridine-5-carbaldehyde 23100-12-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-22
Henan Fengda Chemical Co., Ltd
- Product
- 6-Chloronicotinaldehyde 23100-12-1
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22
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