Structure
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Menaquinone 7

Structure
Product Name
Menaquinone 7
CAS No.
2124-57-4
Chemical Name
Menaquinone 7
Synonyms
MK-7;MENAQUINONE-7;Vitamin K2-7;Menlaquinone 7;Menaquinone 7, Synthetic (90%);Vitamin MK 7;Vitamin K2(35);Menaquinone K7;Menaquinone-7(MK-7);Menatetrenone (MK-7)
CBNumber
CB7206357
Molecular Formula
C46H64O2
Formula Weight
649
MOL File
2124-57-4.mol
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Menaquinone 7 Property

Melting point:
54 °C
Boiling point:
bp0.0002 200° (some dec)
Density 
0.961
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
color 
Pale Yellow to Yellow
Stability:
Light and Temperature Sensitive
InChI
InChI=1S/C46H64O2/c1-34(2)18-12-19-35(3)20-13-21-36(4)22-14-23-37(5)24-15-25-38(6)26-16-27-39(7)28-17-29-40(8)32-33-42-41(9)45(47)43-30-10-11-31-44(43)46(42)48/h10-11,18,20,22,24,26,28,30-32H,12-17,19,21,23,25,27,29,33H2,1-9H3/b35-20+,36-22+,37-24+,38-26+,39-28+,40-32+
InChIKey
RAKQPZMEYJZGPI-LJWNYQGCSA-N
SMILES
C1(=O)C2=C(C=CC=C2)C(=O)C(C)=C1C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C
LogP
14.451 (est)
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Safety

HS Code 
2936299055
Hazardous Substances Data
2124-57-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
900074
Product name
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3)
Purity
≥98 atom % D, ≥95% (CP)
Packaging
1MG
Price
$2420
Updated
2024/03/01
Cayman Chemical
Product number
10011051
Product name
Menaquinone 7
Purity
≥98%
Packaging
1mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
10011051
Product name
Menaquinone 7
Purity
≥98%
Packaging
5mg
Price
$481
Updated
2024/03/01
Cayman Chemical
Product number
10011051
Product name
Menaquinone 7
Purity
≥98%
Packaging
10mg
Price
$841
Updated
2024/03/01
TRC
Product number
M218600
Product name
Menaquinone7,Synthetic(90%)
Packaging
50mg
Price
$275
Updated
2021/12/16
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Menaquinone 7 Chemical Properties,Usage,Production

Structure

Vitamin K2 is a fat-soluble vitamin that has the ability to cross the blood-brain barrier (BBB) due to its lipophilic nature. All the existing forms of vitamin K2 consist of a common moiety in their chemical structure, which is a 2-methyl-1,4-naphthoquinone ring. This core chemical structure of vitamin K2 is called menadione. Each form differs from the others with respect to the degree of saturation and length of side chains. Menaquinone (also called MK-n) differs in the length of its side chain, varying from 4 to 15 isoprene units; n denotes the number of isoprene units present in the structure. The figure depicts the chemical structures of members of the vitamin K2 family. The differences in side chains of different forms give each of them a unique potency and absorption efficiency. Menaquinones with the absence of methyl group on naphthoquinone moiety at position 3 are called dimethyl-menaquinones and serve as precursors to menaquinone.

Description

Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods. It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats. In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification. It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.

Chemical Properties

Light Yellow Crystalline Solid

Uses

Vitamin (prothrombogenic)

Uses

Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) can be used as a stable isotope internal standard for data interpretation in specific biological samples.

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-prote ins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health.

Definition

ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation.

General Description

Vitamin K2, also known as menaquinone, is a polyisoprenoid-substituted?napthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium.

Side effects

Menlaquinone 7 is usually well tolerated and side effects are rare. Mild digestive symptoms, such as nausea, bloating or diarrhoea, may occur with overdose, but these side effects are usually temporary and will subside on their own. There have been some reports of allergic reactions to Vitamin K2 MK7, including skin rashes and breathing difficulties. As Menlaquinone 7 interferes with the action of blood thinners such as warfarin. Therefore, if you are taking blood thinners, be sure to consult your healthcare provider before taking Vitamin K2 MK7 or any other vitamin or supplement. Therefore, if you are taking blood thinners, be sure to consult your healthcare provider before taking Vitamin K2 MK7 or any other vitamin or supplement.

Source

Vitamin K2, such as Menaquinone 7 (MK-7), can be obtained through natural fermentation and is shown to be the most superior form of K2. The main sources of menaquinones include animal-based foods like meat, fish, dairy products, etc. Short-chain menaquinones like MK-4 (having four isoprene units) are found majorly in animal-based food products. Menaquinones having long chains such as MK-7 to MK-13 are primarily synthesized by bacteria that include species of aerobic, anaerobic, facultative, as well as obligate anaerobic bacterial species that include Bacillus, Corynebacterium, Escherichia, Lactococcus and Vibrio. Some of these bacterial species are present as microflora in the gut. MK-7 or K2-7 is present in very high concentrations in a Japanese traditional food called natto. Natto is made by fermenting soybeans using Bacillus subtilis. Another source of menaquinones is the microflora of the intestine. Although intestinal synthesis has been shown to produce significant quantities of menaquinones, absorption from this source is inefficient to fulfill the required quantities. Menaquinone is analogous to ubiquinone in function as ubiquinone also contains isoprenoid side chains of varying lengths and, therefore, is used as an electron carrier in the electron transport chain by bacteria. Vitamin K2-7 is also detected in human milk samples depending on dietary intake[1].

References

[1] Nikita Jadhav. “Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities.” Frontiers in Pharmacology (2022): 896920.

Menaquinone 7 Preparation Products And Raw materials

Raw materials

Preparation Products

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Menaquinone 7 Suppliers

Shanghai Reson biotech Co., Ltd
Tel
021-56916686
Fax
021-61532877
Email
info@vk-2.com
Country
China
ProdList
15
Advantage
58
Shanghai Linka Biotechnology Co., Ltd.
Tel
15901858719
Fax
qq2126935757
Email
2126935757@qq.com
Country
China
ProdList
311
Advantage
55
SHANDONG OCTAGON CHEMICALS LIMITED
Tel
0535-15589503653 15589503653
Email
2959135512@qq.com
Country
China
ProdList
235
Advantage
58
Wuhan Fengyao Tonghui Chemical Products Co. LTD
Tel
027-87466205 15377579727
Email
1228964013@qq.com
Country
China
ProdList
8558
Advantage
58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.
Tel
029-86638659 18109298458
Email
50844069@qq.com
Country
China
ProdList
17
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-59402396 13419635609
Fax
027-83989310
Email
13419635609@163.com
Country
China
ProdList
1973
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@163.com
Country
China
ProdList
283
Advantage
58
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
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View Lastest Price from Menaquinone 7 manufacturers

Sinoway Industrial co., ltd.
Product
Vitamin K2 MK-7 2124-57-4
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2024-06-27
Hebei Weibang Biotechnology Co., Ltd
Product
Vitamin K2 2124-57-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-04
BINBO BIOLOGICAL CO.,LTD
Product
Menlaquinone 7 2124-57-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
1000 kg
Release date
2024-04-05

2124-57-4, Menaquinone 7Related Search:


  • MENAQUINONE-7
  • (all-E)-2-(3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-1,4-naphthalenedione
  • Menaquinone K7
  • Vitamin K2(35)
  • Vitamin MK 7
  • Menlaquinone 7
  • MK-7
  • 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyl-2,6,10,14,18,22,26-octacosaheptenyl]-3-methyl-1,4-naphthalenedione
  • Menaquinone-7 Standard
  • Menaquinone 7, Synthetic
  • Menaquinone 7, Synthetic (90%)
  • 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione
  • Heptamethene naphthene quinone
  • Vitamin K2 (MENAQUINONE-7)
  • Menaquinone-7, >98% ( Vitamin K2, MK-7)
  • Menatetrenone (MK-7)
  • Vitamin K2-7
  • 1,4-Naphthalenedione, 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaen-1-yl]-3-methyl-
  • Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3)
  • Vitamin K2(35) USP/EP/BP
  • Vitamin K2(MK-7),Widely advantage spot
  • Vitamin-K2-7 (menaquinone-7)
  • 2-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione
  • Menaquinone-7(MK-7)
  • Menaquinone-7 (3 x 50 mg) (Vitamin K2) (1381119)
  • 2H7]-Menaquinone-7 ([2H7]-MK7)
  • 13C6]-Menaquinone-7 ([13C6]-MK7)
  • Vitamin K2(Menaquinone-7)(P)
  • Menaquinone-7) 1.0% in Olive Oil
  • Vitamin K2 ( all trans MK7)
  • Vitamin K2(MK-7) in Acetonitrile
  • 2124-57-4
  • C10H4O2CH3C5H77H
  • C46H64O2
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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