ChemicalBook > CAS DataBase List > 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Product Name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
CAS No.
981-34-0
Chemical Name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Synonyms
DB11;(9β,11β,16β)-;Einecs 213-563-4;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid;16-BETA METHYL EPOXIDE;DB11(16B-Methyl Epoide);DB11(16β-Methyl Epoide)
CBNumber
CB72129663
Molecular Formula
C22H28O5
Formula Weight
372.45
MOL File
981-34-0.mol
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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Property

Melting point:
210-220 ºC
Boiling point:
564.9±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
vapor pressure 
0-357.304Pa at 25℃
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
form 
Solid
pka
12.56±0.70(Predicted)
color 
White to Light Beige
InChIKey
GBDXNHBVYAMODG-OBDZOPJXNA-N
SMILES
C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E589175
Product name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging
250mg
Price
$95
Updated
2021/12/16
TRC
Product number
E589175
Product name
9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging
2g
Price
$160
Updated
2021/12/16
Usbiological
Product number
262572
Product name
Betamethasone 9,11-epoxide
Packaging
1g
Price
$360
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18569
Product name
Betamethasone 9,11-epoxide
Packaging
50g
Price
$450
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB18569
Product name
Betamethasone 9,11-epoxide
Packaging
25g
Price
$250
Updated
2021/12/16
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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

Description

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemical Properties

Off-White Solid

Uses

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.

Preparation

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Suppliers

Canada 2 China 222 India 12 United Kingdom 1 United States 8 Global 245
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
Dalton Chemical Laboratories, Inc.
Tel
--
Fax
--
Email
chemist@dalton.com
Country
Canada
ProdList
965
Advantage
78
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View Lastest Price from 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione manufacturers

Nantong Guangyuan Chemicl Co,Ltd
Product
16-beta Methyl Epoxide 981-34-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-03
LY Global chemicals co.,ltd .
Product
9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione 981-34-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98.0%min
Supply Ability
100kg
Release date
2023-03-11
Hebei Zhanyao Biotechnology Co. Ltd
Product
Betamethasone 9,11-Epoxide 981-34-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-08

981-34-0, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Related Search:

16-beta Methyl Epoxide ETHYLENE OXIDE Betamethasone 17-valerate Propylene glycol Estradiol Betamethasone 21-phosphate disodium 4,4'-Diphenylmethane diisocyanate Phenolic epoxy resin Basic Violet 1 Polyethylene Glycol Betamethasone 21-acetate Methylparaben Methylene Blue Kresoxim-methyl Acetonitrile BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Betamethasone Methyl acrylate

  • 16-BETA METHYL EPOXIDE
  • 9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
  • DB11
  • (9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • Einecs 213-563-4
  • Betamethasone 9,11-Epoxide
  • (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione
  • (9β,11β,16β)-
  • 9beta,11beta-Epoxy-1
  • DB11(16B-Methyl Epoide)
  • DB11(16β-Methyl Epoide)
  • (4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
  • Betamethasone epoxide
  • (4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one
  • Pregna-1,4-diene-3,20-dione,9
  • 17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione
  • Beclomethasone EP Impurity R
  • Betamethasone Impurity 5（Betamethasone EP Impurity E）
  • Beclometasone Dipropionate?EP Impurity R
  • 16-beta Methyl Epoxid
  • 9,11beta-Epoxy-17,21-dihydroxy-16be
  • 9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]
  • Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-
  • Beclomethasone Impurity 6
  • Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione
  • Beclomethasone propionate EP impurity R
  • Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)
  • 9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...
  • DB11(16β-Methyl Epoxide)
  • 11beta-Epoxy-17alpha
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • 9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione
  • Beclomethasone dipropionate EP Impurity R
  • 9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione
  • Beclometasone Dipropionate Impurity R
  • Beclometasone Propionate EP Impurity R
  • Betamethasone Impurity E
  • Beclometasone Propionate EP Impurity R（Betamethasone EP Impurity E）
  • Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)
  • Betamethasone epoxy hydrolysate
  • 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione
  • 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met
  • 93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11)
  • (9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Betamethasone epoxide hydrolase
  • Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)
  • Beclometasone Impurity R
  • 981-34-0
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Steroids
  • 981-34-0