9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

ChemicalBook > CAS DataBase List > 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Product Name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
CAS No.: 981-34-0
Chemical Name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Synonyms: DB11;(9β,11β,16β)-;Einecs 213-563-4;9beta,11beta-Epoxy-1;11beta-Epoxy-17alpha;Betamethasone epoxide;16-beta Methyl Epoxid;16-BETA METHYL EPOXIDE;DB11(16B-Methyl Epoide);DB11(16β-Methyl Epoide)
CBNumber: CB72129663
Molecular Formula: C22H28O5
Formula Weight: 372.45
MOL File: 981-34-0.mol

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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Property

Melting point:: 210-220 ºC
Boiling point:: 564.9±50.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
vapor pressure: 0-357.304Pa at 25℃
storage temp.: Refrigerator
solubility: Chloroform (Slightly, Heated), Dioxane (Slightly, Heated), DMSO (Slightly, Heated)
form: Solid
pka: 12.56±0.70(Predicted)
color: White to Light Beige
InChIKey: GBDXNHBVYAMODG-OBDZOPJXNA-N
SMILES: C[C@]12C=CC(=O)C=C1CC[C@@]1([H])[C@]3([H])C[C@H](C)[C@](O)(C(=O)CO)[C@@]3(C)C[C@@H]3O[C@]213 |&1:1,10,12,15,17,23,26,28,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E589175
Product name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging: 250mg
Price: $95
Updated: 2021/12/16

TRC

Product number: E589175
Product name: 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Packaging: 2g
Price: $160
Updated: 2021/12/16

Usbiological

Product number: 262572
Product name: Betamethasone 9,11-epoxide
Packaging: 1g
Price: $360
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18569
Product name: Betamethasone 9,11-epoxide
Packaging: 50g
Price: $450
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18569
Product name: Betamethasone 9,11-epoxide
Packaging: 25g
Price: $250
Updated: 2021/12/16

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9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

Description

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione (Betamethasone EP Impurity E) is a metabolite of Mometasone Furoate (M490000) which is a tropical corticosteroid used as an anti-inflammatory. Low solubility in most solvent. 9,11β-epoxysteroid compounds can be prepared by 9-position fluorination to obtain dexamethasone. By modifying its 3-bit, 6-bit, 16-bit, and 21-bit, a series of drugs can be prepared.

Chemical Properties

Off-White Solid

Uses

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione is a metabolite of Mometasone furoate. It has low solubility in most solvents.

Preparation

Add sodium sulfite and sodium hydroxide to water, stir to dissolve, and then add methanol. The raw material was added for hydrolysis reaction. After the reaction for 3h, glacial acetic acid was added to adjust the pH=6~8. The water was added to the solution and crystallize at 0 ℃. Finally, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione was obtained after purification.

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione manufacturers

Nantong Guangyuan Chemicl Co,Ltd

Product: 16-beta Methyl Epoxide 981-34-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-11-03

LY Global chemicals co.,ltd .

Product: 9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione 981-34-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98.0%min
Supply Ability: 100kg
Release date: 2023-03-11

Hebei Zhanyao Biotechnology Co. Ltd

Product: Betamethasone 9,11-Epoxide 981-34-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-08

981-34-0, 9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione Related Search:

16-beta Methyl Epoxide ETHYLENE OXIDE Betamethasone 17-valerate Propylene glycol Estradiol Betamethasone 21-phosphate disodium 4,4'-Diphenylmethane diisocyanate Phenolic epoxy resin Basic Violet 1 Polyethylene Glycol Betamethasone 21-acetate Methylparaben Methylene Blue Kresoxim-methyl Acetonitrile BETAMETHASONE DIPROPIONATE MM(CRM STANDARD) Betamethasone Methyl acrylate

16-BETA METHYL EPOXIDE

9beta,11beta-epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione

DB11

(9β)-9,11β-Epoxy-16β-methyl-17,21-dihydroxypregna-1,4-diene-3,20-dione

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

Einecs 213-563-4

Betamethasone 9,11-Epoxide

(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione

(9β,11β,16β)-

9beta,11beta-Epoxy-1

DB11(16B-Methyl Epoide)

DB11(16β-Methyl Epoide)

(4aS,4bS,5aS,6aS,7R,8S,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a,8-triMethyl-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one

Betamethasone epoxide

(4aS,4bS,5aS,6aS,7R,9aS,9bS)-7-Hydroxy-7-(2-hydroxyacetyl)-4a,6a-Dimethyl-8-methylene-5a,6,6a,7,8,9,9a,9b,10,11-decahydrocyclopenta[1,2]phenanthro[4,4a-b]oxiren-2(4aH)-one

Pregna-1,4-diene-3,20-dione,9

17α,21-dihydroxy-9β,11β-epoxy-16β-methylpregna-1,4-diene-3,20-dione

Beclomethasone EP Impurity R

Betamethasone Impurity 5（Betamethasone EP Impurity E）

Beclometasone Dipropionate?EP Impurity R

16-beta Methyl Epoxid

9,11beta-Epoxy-17,21-dihydroxy-16be

9Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione[DB11]

Pregna-1,4-diene-3,20-dione, 9,11-epoxy-17,21-dihydroxy-16-methyl-, (9β,11β,16β)-

Beclomethasone Impurity 6

Beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-methylene-pregna-1,4-diene-3,20-dione

Beclomethasone propionate EP impurity R

Beclomethasone Impurity 15(Beclometasone Dipropionate EP Impurity R)

9-beta,11-beta-epoxy-17-alpha,21-dihydroxy-16-beta-methylene...

DB11(16β-Methyl Epoxide)

11beta-Epoxy-17alpha

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione

9,11β-Epoxy-17,21-dihydroxy-16β-methyl-9β-pregna-1,4-diene-3,20-dione

Beclomethasone dipropionate EP Impurity R

9-β,11-β-epoxy-17-α,21-dihydroxy-16-beta-methylenepregna-1,4-diene-3,20-dione

Beclometasone Dipropionate Impurity R

Beclometasone Propionate EP Impurity R

Betamethasone Impurity E

Beclometasone Propionate EP Impurity R（Betamethasone EP Impurity E）

Beclomethasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)

Betamethasone 9,11-Epoxide (Beclomethasone Dipropionate EP Impurity R)

Betamethasone epoxy hydrolysate

9β,11β-Epoxy-17,21-dihydroxy-16β-methylpregnα-1,4-diene-3,20-dione

9beta,11beta-Epoxy-17alpha,21-dihydroxy-16beta-met

93.113-Epoxy-17a,21-dihydroxy-16p -methylenepregna-1.4-diene-3.20-dione(DB11)

Beclometasone Dipropionate EP Impurity R (Betamethasone 9,11-Epoxide)

(9β,11β,16β)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

981-34-0

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids

981-34-0