5-Bromo-2-iodobenzoic acid

Product Name: 5-Bromo-2-iodobenzoic acid
CAS No.: 21740-00-1
Chemical Name: 5-Bromo-2-iodobenzoic acid
Synonyms: NSC 190696;RARECHEM AL BO 0892;5-BROMO-2-IODOBENZOIC ACID;5-Bromo-2-iodobenzoicAcid>Benzoic acid, 5-broMo-2-iodo-;5-Bromo-2-iodobenzoic acid 97+%;5-BroMo-2-iodobenzoic acid
CBNumber: CB7222623
Molecular Formula: C7H4BrIO2
Formula Weight: 326.91
MOL File: 21740-00-1.mol

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5-Bromo-2-iodobenzoic acid Property

Melting point:: 161-163°C
Boiling point:: 133-134 °C(Press: 1 Torr)
Density: 2.331±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: Solid
pka: 2.47±0.10(Predicted)
color: White to Light yellow
Water Solubility: Slightly soluble in water.
Sensitive: Light Sensitive
InChI: InChI=1S/C7H4BrIO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)
InChIKey: IGBNDUKRHPTOBP-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(Br)=CC=C1I
CAS DataBase Reference: 21740-00-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 763462
Product name: 5-Bromo-2-iodobenzoic acid
Purity: 97%
Packaging: 5g
Price: $82
Updated: 2022/05/15

TCI Chemical

Product number: B4296
Product name: 5-Bromo-2-iodobenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $42
Updated: 2025/07/31

TRC

Product number: B687793
Product name: 5-Bromo-2-iodobenzoic Acid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B687793
Product name: 5-Bromo-2-iodobenzoic Acid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 001778
Product name: 5-Bromo-2-iodobenzoic acid
Purity: 98%
Packaging: 25g
Price: $44
Updated: 2021/12/16

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5-Bromo-2-iodobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

off-white light yellow powder

Uses

It is an important raw material and intermediate used in organic synthesis agrochemical, pharmaceutical and dyestuff field.

Synthesis

5794-88-7

21740-00-1

General procedure for the synthesis of 5-bromo-2-iodobenzoic acid from 2-amino-5-bromobenzoic acid: a solution of 2-amino-5-bromobenzoic acid (3.9 g, 0.018 mol), sodium nitrite (NaNO2, 1.5 g, 0.022 mol) and sodium hydroxide (NaOH, 0.90 g, 0.023 mmol) in water (55 mL) was added dropwise to a stirred of a concentrated hydrochloric acid solution. The hydrochloric acid (HCl, 6.4 mL) in water (9 mL) solution was cooled at 0°C for 1.5 hours. After dropwise addition, stirring was continued for 30 minutes at 0°C. The formed diazonium salt suspension was added to a stirred solution of potassium iodide (KI, 4.5 g, 0.027 mol) and concentrated hydrochloric acid. A solution of sulfuric acid (H2SO4, 1.1 mL) in water (7.4 mL) was slowly added over 20 minutes at 35 to 40°C. The mixture was then heated to 90 °C and stirred for 30 min. Unreacted iodine was removed by steam distillation. The mixture was stirred and cooled. The crude product was filtered and washed with cold water, then dissolved in 40% aqueous sodium hydroxide. The polymer fraction was separated by decantation and the clarified solution was acidified with concentrated hydrochloric acid. The product was extracted with ether (Et2O). The extract was dried with anhydrous magnesium sulfate (MgSO4) and concentrated in vacuum. The residue was crystallized from a solvent mixture of methanol (MeOH) and water (H2O) (1:1, v/v) to give 5-bromo-2-iodobenzoic acid (3.56 g, 0.0109 mol, 60% yield) as a light yellow solid.

References

[1] Angewandte Chemie - International Edition, 2011, vol. 50, # 46, p. 10851 - 10854
[2] Organic Letters, 2008, vol. 10, # 14, p. 3001 - 3004
[3] Tetrahedron, 2011, vol. 67, # 1, p. 125 - 143
[4] Angewandte Chemie - International Edition, 2012, vol. 51, # 12, p. 2925 - 2929
[5] Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 1, p. 86 - 109

5-Bromo-2-iodobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-iodobenzoic acid Suppliers

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View Lastest Price from 5-Bromo-2-iodobenzoic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Bromo-2-iodobenzoic acid 21740-00-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-11

Hebei Chuanghai Biotechnology Co,.LTD

Product: 5-Bromo-2-Iodobenzoic Acid 21740-00-1
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

Henan Fengda Chemical Co., Ltd

Product: 5-Bromo-2-iodobenzoic acid 21740-00-1
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

21740-00-1, 5-Bromo-2-iodobenzoic acidRelated Search:

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5-BROMO-2-IODOBENZOIC ACID

RARECHEM AL BO 0892

Benzoic acid, 5-broMo-2-iodo-

5-Bromo-2-iodobenzoic acid 97+%

5-<WBR>BroMo-<WBR>2-<WBR>iodobenzoic acid

NSC 190696

5-Bromo-2-iodobenzoicAcid&gt

21740-00-1

C7H3BrIO2

Benzoic acid

Acids & Esters

Bromine Compounds

Iodine Compounds

Benzoic acid series

bc0001