Cefazedone
- Product Name
- Cefazedone
- CAS No.
- 56187-47-4
- Chemical Name
- Cefazedone
- Synonyms
- cefazedone;REFOSPORIN;Refosporen;Cefoxitone;Ceftazidone;Cefazedone acid;(6r-trans)--8-oxo;CEFAZEDONE SODIUM;Cefazedone USP/EP/BP;(6R-trans)-Cefazedone
- CBNumber
- CB7227198
- Molecular Formula
- C18H15Cl2N5O5S3
- Formula Weight
- 548.44
- MOL File
- 56187-47-4.mol
Cefazedone Property
- Melting point:
- 157 - 160°C
- Density
- 1.78±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 2.61±0.50(Predicted)
- form
- Solid
- color
- White to Off-White
- CAS DataBase Reference
- 56187-47-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C241500
- Product name
- Cefazedone
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 005849
- Product name
- Cefazedone
- Packaging
- 10mg
- Price
- $418
- Updated
- 2021/12/16
- Product number
- FC19847
- Product name
- Cefazedone
- Packaging
- 2g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-0079538
- Product name
- Cefazedone
- Purity
- ≥98.0%
- Packaging
- 25mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FC19847
- Product name
- Cefazedone
- Packaging
- 5G
- Price
- $140
- Updated
- 2021/12/16
Cefazedone Chemical Properties,Usage,Production
Originator
Cefazedone Sodium,Arocor Holdings Inc.
Uses
Semi-synthetic cephalosporin antibiotic. Antibacterial.
Definition
ChEBI: A cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and [(3,5-dichloro-4-oxopyridin-1(4H)-yl)acetamido side-groups.
Manufacturing Process
A solution of 1 eq. of the tert-butyl ester of 7-aminocephalosporanic acid and
1 eq. of dicyclohexylcarbodiimide in 100 ml of methylene chloride/DMF (1:1)
is cooled to 0°C. The mixture is combined with 1 eq. of 3,5-dichloro-4-
pyridone-1-acetic acid; after 5 min the ice bath is removed and the mixture
agitated for another 30 min at 25°C. The thus-formed urea is filtered off and
the filtrate filtered over silica gel (eluent: ethyl acetate/1% methanol). The
solvent is concentrated by evaporation, and the thus-obtained tert-butyl ester
of 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid
is crystallized from ether.
1 eq. of the tert-butyl ester is dissolved in 30 ml of trifluoroacetic acid. After
30 minutes, the solution is evaporated and the thus-produced 7-(3,5-dichloro-
1,4-dihydro-4-oxo-1-pyridylacetamido)cephalosporanic acid crystallized from
ether.
1 eq. of the obtained 7-(3,5-dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)
cephalosporanic acid is dissolved in 60 ml of saturated aqueous sodium
bicarbonate solution at a pH of below 7 and combined with 1 eq. of 5-methyl-
1,3,4-thiadiazole-2-thiol in 20 ml of acetone. The reaction solution is agitated
for 2 hours at 80°C and at a pH of 6.3 under a nitrogen atmosphere. The
acetone is thereupon removed, the solution is washed with ether and acidified
to pH 2. The thus-obtained 3-(1-methyltetrazolyl-5-mercaptomethyl)-7-(3,5-
dichloro-1,4-dihydro-4-oxo-1-pyridylacetamido)-3-cephem-4-carboxylic acid is
filtered off and dried. IR spectrum confirmed the structure of cefazedone.
In practice it is usually used as sodium salt.
Therapeutic Function
Antibiotic
Cefazedone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cefazedone manufacturers
- Product
- CEFAZEDONE SODIUM 56187-47-4
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-13
- Product
- Cefazedone 56187-47-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- Cefazedone 56187-47-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-25