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COPTISINE

Product Name
COPTISINE
CAS No.
3486-66-6
Chemical Name
COPTISINE
Synonyms
Coptisin;COPTISINE;COPTISINE(P);Coptisine Sulfate;2-Benzenedioic acid;COPTISINE USP/EP/BP;Coptisine, 10 mM in DMSO;Coptisine, 98%, from Coptis chinensis Franch.;6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium;Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-
CBNumber
CB7246829
Molecular Formula
C19H14NO4+
Formula Weight
320.32
MOL File
3486-66-6.mol
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COPTISINE Property

Melting point:
212-217 °C
storage temp. 
Store at 2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
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Safety

Hazardous Substances Data
3486-66-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
300099
Product name
Coptisine
Packaging
20mg
Price
$575
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC73787
Product name
Coptisine
Packaging
5mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC73787
Product name
Coptisine
Packaging
10mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
N1737
Product name
Coptisine
Packaging
20mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC73787
Product name
Coptisine
Packaging
25mg
Price
$250
Updated
2021/12/16
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COPTISINE Chemical Properties,Usage,Production

Chemical Properties

Very slightly soluble in water, slightly soluble in ethanol, soluble in alkali. Derived from the root of the poppy family plant celandine.

Uses

Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.

Definition

ChEBI: A natural product found in Coptis japonica.

Hazard

A poison.

Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx.

in vivo

Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2].

IC 50

IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki)

References

[1] Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. DOI:10.3233/JAD-140414
[2] He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. DOI:10.1007/s11745-014-3983-7
[3] Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565. DOI:10.1177/1010428317694565

COPTISINE Preparation Products And Raw materials

Raw materials

Preparation Products

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COPTISINE Suppliers

China 162 Germany 4 India 1 United Kingdom 3 United States 18 Global 188
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apin Chemicals Ltd.
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6807
Advantage
42
Apin Chemicals Limited (UK)
Tel
--
Fax
--
Email
info@apinchemicals.com
Country
United Kingdom
ProdList
6184
Advantage
60
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View Lastest Price from COPTISINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Coptisine 3486-66-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20T
Release date
2024-07-10
Baoji Guokang Healthchem co.,ltd
Product
COPTISINE 3486-66-6
Price
US $630.00/G
Min. Order
1G
Purity
98%
Supply Ability
100kgs
Release date
2021-06-07
Career Henan Chemical Co
Product
COPTISINE 3486-66-6
Price
US $2.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000kg
Release date
2018-08-10

3486-66-6, COPTISINERelated Search:

Cevadine veratramine daurisoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRIDINE L-Hyoscyamine Worenine menisdaurin Xanthiazone Tetrahydroepiberberine, Sinactine 5,6-Dihydro-2,3-(methylenedioxy)-9,10-dimethoxy-13-methyldibenzo[a,g]quinolizinium Daurinoline Xanthiside epiberberine (-)-STYLOPINE COPTISINE COPTISINE CHLORIDE,COPTISINE CHLORIDE(P) COPTISINE CHLORIDE(RG)

  • COPTISINE
  • Coptisin
  • 5,6-Dihydro-2,3:9,10-bis(methylenedioxy)dibenzo[a,g]quinolizinium
  • 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium
  • Coptisine Sulfate
  • Coptisine, 98%, from Coptis chinensis Franch.
  • COPTISINE(P)
  • Bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizinium,6,7-dihydro-
  • COPTISINE USP/EP/BP
  • 2-Benzenedioic acid
  • 6,7-Dihydro-[1,3]dioxolo[4',5':7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium
  • Coptisine, 10 mM in DMSO
  • 3486-66-6
  • C19H14NO4
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Alkaloids