FUCHSIN BASIC Property

Melting point:

250 °C

Boiling point:

300℃[at 101 325 Pa]

Density 

0.999 g/mL at 20 °C

vapor pressure 

0Pa at 25℃

refractive index 

n20/D 1.334

Flash point:

48 °F

storage temp. 

2-8°C

solubility 

H2O: soluble1mg/mL

form 

liquid

Colour Index 

42510

color 

Green to dark green

PH

5-6 (1g/l, H2O, 25°C)

Water Solubility 

4 G/L (25 ºC)

λmax

543 nm

Merck 

14,5652

BRN 

4166684

Biological Applications

Detecting cancer; treating Jock itch,oral fungal infection,piles; periodontal disease

LogP

1.632 at 25℃

IARC

2B (Vol. Sup 7, 57, 99, 100F) 2012

EPA Substance Registry System

C.I. Basic Violet 14 (632-99-5)

Safety

Hazard Codes 

F,Xn

Risk Statements 

40-22

Safety Statements 

7-16-36/37

WGK Germany 

3

RTECS 

CX9850000

TSCA 

Yes

HS Code 

3204 13 00

Hazardous Substances Data

632-99-5(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

FUCHSIN BASIC Chemical Properties,Usage,Production

Chemical Properties

Green crystal powder

Uses

As a dye or in manufacture of other dyes.

Uses

Biological stain for distinguishing coli and aerogene bacteriaBasic Fuchsin is useful for Ziehl-Neelson staining to detect acid-fast bacilli. It is also used to stain tubercle bacillus and bacterial flagella. It plays an important role for tissue sections to visualize elastic fibers, cardiac and skeletal muscle tissue. It also acts as bacterial and histological stains. Further, it is used to stain cellular elements, certain tissues, bacteria and also acts as a local anti-infective.

Definition

ChEBI: A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the major constituents of Basic fuchsin, together with pararosanilin, magenta II and new fuchsin.

General Description

Dark green powder. A dye derived from triphenylmethane.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

FUCHSIN BASIC neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Easily reduced to colorless leuco-bases .

Fire Hazard

Flash point data for FUCHSIN BASIC are not available, but FUCHSIN BASIC is probably combustible.

Flammability and Explosibility

Not classified

Clinical Use

Basic fuchsin is a mixture of the chlorides of rosaniline andp-rosaniline. It exists as a green crystalline powder with ametallic appearance. The compound is soluble in water andin alcohol but insoluble in ether. Basic fuchsin is a componentof carbol–fuchsin solution (Castellani’s paint), which isused topically in the treatment of fungal infections, notablyringworm and athlete’s foot.

Properties and Applications

Purification Methods

Purify the dye by dissolving it in EtOH, filtering and adding H2O. Filter or centrifuge it and wash the precipitate with Et2O and dry it in air. It has also been recrystallised from water and dried in vacuo at 40o. The crystals have a metallic green lustre. It has UV max in EtOH at 543nm ( 93,000). Its solubility in H2O is 0.26%. A carmine red colour is obtained in EtOH. It is paraRosaniline with a methyl group. [Scalan J Am Chem Soc 57 887 1937.]