LY2886721

ChemicalBook > CAS DataBase List > LY2886721

Uses

Product Name: LY2886721
CAS No.: 1262036-50-9
Chemical Name: LY2886721
Synonyms: CS-367;4-d][1;LY2886721;N-(3-((4aS;LY2886721HCL;7aS)-2-amino-4a;LY2886721, >=98%;LY2886721 HCL SALT;LY2886721 USP/EP/BP;LY2886721/LY-2886721
CBNumber: CB72516034
Molecular Formula: C18H16F2N4O2S
Formula Weight: 390.41
MOL File: 1262036-50-9.mol

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LY2886721 Property

Density: 1.57
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥19.52 mg/mL in DMSO
form: solid
pka: 10.08±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21599
Product name: LY2886721
Purity: ≥98%
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 21599
Product name: LY2886721
Purity: ≥98%
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 21599
Product name: LY2886721
Purity: ≥98%
Packaging: 10mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 21599
Product name: LY2886721
Purity: ≥98%
Packaging: 25mg
Price: $651
Updated: 2024/03/01

Usbiological

Product number: 474129
Product name: LY 2886721
Packaging: 100mg
Price: $1890
Updated: 2021/12/16

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LY2886721 Chemical Properties,Usage,Production

Uses

LY2886721 is a BACE inhibitor used to treat Alzheimer's disease.

Biological Activity

ly2886721 is an oral and furothiazine-based inhibitor of β site-amyloid protein cleaving enzyme (bace) with ic50 of 20.3nm. this product has the potency for the treatment of alzheimer's disease.bace, also known as beta-secretase 1, is an aspartic-acid protease that plays important role in the formation of myelin sheaths in peripheral nerve cells.in pdapp mice, oral administration of ly2886721 resulted in a reduction in brain aβ, c99 and sappβ in a dose-dependent pattern 2. aβ levels in the brain were decreased by 20% -65% as compared with the vehicle-treated groups 3 hours after treatment of ly2886721 at a dosage of 3-30 mg/kg per mice. in addition, ly2886721 significantly lowers plasma and csf aβs in the mad study 1.

in vitro

treatment of ly2886721 leads to the inhibition of aβ in hek293swe with ic50 of 18.7nm and pdapp neuronal culture with ic50 10.7 nm1. ly2886721 decreases csf sappβ and increases csf sappα in a dose- dependent manner 2.

target

BACE

References

1. vassar r. bace1 inhibitor drugs in

LY2886721 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LY2886721 manufacturers

Career Henan Chemical Co

Product: LY2886721 1262036-50-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kgs
Release date: 2019-12-17

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LY2886721

N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide

LY2886721 HCL SALT

LY2886721HCL

N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide LY2886721

LY2886721, >=98%

N-(3-((4aS,7aS)-2-aMino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinaMide

LY2886721/LY-2886721

N-(3-((4AS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)

CS-367

3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide

4-d][1

7aS)-2-amino-4a

7a-tetrahydro-4H-furo[3

LY 2886721;LY-2886721;N-(3-((4AS;7AS)-2-AMINO-4A;5;7;7A-TETRAHYDRO-4H-FURO[3;4-D][1;3]THIAZIN-7A-YL)-4-FLUOROPHENYL)-5-FLUOROPICOLINAMIDE

N-(3-((4aS

2-Pyridinecarboxamide, N-[3-[(4aS,7aS)-2-amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-

LY2886721 USP/EP/BP

N-(3-((4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-fluoropicolinamide

1262036-50-9

262036-49-6

C18H16F2N4O2S

Inhibitors