Dehydrocrenatidine
- Product Name
- Dehydrocrenatidine
- CAS No.
- 65236-62-6
- Chemical Name
- Dehydrocrenatidine
- Synonyms
- TOP3;TOP 3;TOP-3;Dehydrocrenatidine;O-Methylpicrasidine I;1-ethenyl-4,8-dimethoxy-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 1-ethenyl-4,8-dimethoxy-
- CBNumber
- CB72519671
- Molecular Formula
- C15H14N2O2
- Formula Weight
- 254.28
- MOL File
- 65236-62-6.mol
Dehydrocrenatidine Property
- form
- Solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CFN97116
- Product name
- Dehydrocrenatidine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $463
- Updated
- 2021/12/16
- Product number
- CD32000710
- Product name
- Dehydrocrenatidine
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $730
- Updated
- 2021/12/16
Dehydrocrenatidine Chemical Properties,Usage,Production
Uses
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain[1][2].
in vivo
Dehydrocrenatidine inhibits JAK-STAT3 dependent DU145 and MDA-MB-468 cell survival and induces cell apoptosis. Dehydrocrenatidine inhibits JAKs-JH1 domain over-expression induced STAT3 and STAT1 phosphorylations[1].
Dehydrocrenatidine diminishes IL-6, IFNα and IFNγ stimulated STAT3 phosphorylation as well as constitutive STAT3 phosphorylation[1].
DHCT suppresses both tetrodotoxin-resistant (TTX-R) and sensitive (TTX-S) voltage-gated sodium channel (VGSC) currents with IC50 values of 12.36 μM and 4.87 μM, respectively[2].
References
[1] Jing Zhang, et al. Dehydrocrenatidine is a novel janus kinase inhibitor. Mol Pharmacol. 2015 Apr;87(4):572-81. DOI:10.1124/mol.114.095208
[2] Fang Zhao, et al. Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain. Toxins (Basel). 2019 Apr 18;11(4):229. DOI:10.3390/toxins11040229
Dehydrocrenatidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dehydrocrenatidine manufacturers
- Product
- Dehydrocrenatidine 65236-62-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons
- Release date
- 2020-03-12