ChemicalBook > CAS DataBase List > BMS707035

BMS707035

Product Name: BMS707035
CAS No.: 729607-74-3
Chemical Name: BMS707035
Synonyms: CS-455;BMS707035;BMS707035 USP/EP/BP;BMS 707035;BMS707035;BMS-707035, 10 mM in DMSO;2-(1,1-DIOXOTHIAZINAN-2-YL)-N-[(4-FLUOROPHENYL)METHYL]-5-HYDROXY-1-METHYL-6-OXOPYRIMIDINE-4-CARBOXAMIDE;2-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide;2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1l4,2-thiazinane-1,1-bis(olate);4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin;N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-4-pyrimidinecarboxamide
CBNumber: CB72526158
Molecular Formula: C17H19FN4O5S
Formula Weight: 410.42
MOL File: 729607-74-3.mol

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BMS707035 Property

Density: 1.54
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥41 mg/mL in DMSO
form: Powder
pka: 4.50±1.00(Predicted)
color: Off-white to pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B596310
Product name: BMS-707035
Packaging: 50mg
Price: $1020
Updated: 2021/12/16

ApexBio Technology

Product number: A4069
Product name: BMS-707035
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0493
Product name: BMS-707035
Purity: 99.95%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

ApexBio Technology

Product number: A4069
Product name: BMS-707035
Packaging: 10mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0493
Product name: BMS-707035
Purity: 99.95%
Packaging: 10mg
Price: $125
Updated: 2021/12/16

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BMS707035 Chemical Properties,Usage,Production

Uses

BMS-707035 is a specific HIV-I integrase (IN) inhibitor.

in vivo

BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species^[1].
Pharmacokinetic Parameters of BMS-707035 in rat, dog and monkey (IV)^[1].

	Rat	Monkey	Dog
IV dose (mg/kg)	0.87	1	1
CL (ml/min/kg)	9.7	6.8	2.0
T_1/2(h)	4.0	6.5	6.0
V_ss(L/kg)	0.86	0.87	0.45
PO dose (mg/kg)	4.4	5	5.2
C_max(μM)	4.51	6.12	72.8
t_max(h)	0.25	0.25	0.25
AUC (μM*h)	19.1	19.2	162
F (%)	86	56	129

target

HIV-I integrase

BMS707035 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS707035 Suppliers

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729607-74-3, BMS707035Related Search:

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BMS707035

CS-455

BMS 707035;BMS707035

2-(1,1-DIOXOTHIAZINAN-2-YL)-N-[(4-FLUOROPHENYL)METHYL]-5-HYDROXY-1-METHYL-6-OXOPYRIMIDINE-4-CARBOXAMIDE

N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-4-pyrimidinecarboxamide

4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin

4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-

BMS707035 USP/EP/BP

2-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

BMS 707035,HIV-1 integrase strand transfer,HIV,Human immunodeficiency virus,antiviral,BMS707035,phamacokinetics,HIV Integrase,BMS-707035,CYP,inhibit,strand transfer,Inhibitor

BMS-707035, 10 mM in DMSO

2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1l4,2-thiazinane-1,1-bis(olate)

729607-74-3

C17H19FN4O5S

Inhibitors

Inhibitor