ChemicalBook > CAS DataBase List > BMS707035
BMS707035
- Product Name
- BMS707035
- CAS No.
- 729607-74-3
- Chemical Name
- BMS707035
- Synonyms
- CS-455;BMS707035;BMS707035 USP/EP/BP;BMS 707035;BMS707035;BMS-707035, 10 mM in DMSO;2-(1,1-DIOXOTHIAZINAN-2-YL)-N-[(4-FLUOROPHENYL)METHYL]-5-HYDROXY-1-METHYL-6-OXOPYRIMIDINE-4-CARBOXAMIDE;2-(1,1-Dioxido-1,2-thiazinan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide;2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-1l4,2-thiazinane-1,1-bis(olate);4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin;N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-4-pyrimidinecarboxamide
- CBNumber
- CB72526158
- Molecular Formula
- C17H19FN4O5S
- Formula Weight
- 410.42
- MOL File
- 729607-74-3.mol
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BMS707035 Property
- Density
- 1.54
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥41 mg/mL in DMSO
- form
- Powder
- pka
- 4.50±1.00(Predicted)
- color
- Off-white to pink
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B596310
- Product name
- BMS-707035
- Packaging
- 50mg
- Price
- $1020
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0000931
- Product name
- BMS-707035
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $12650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0493
- Product name
- BMS-707035
- Purity
- 99.95%
- Packaging
- 100mg
- Price
- $720
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A4069
- Product name
- BMS-707035
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0493
- Product name
- BMS-707035
- Purity
- 99.95%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
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BMS707035 Chemical Properties,Usage,Production
Uses
BMS-707035 is a specific HIV-I integrase (IN) inhibitor.
in vivo
BMS-707035 has a low clearance effect in the rat, dog and monkey with moderate to long elimination half-lives in all species[1].
Pharmacokinetic Parameters of BMS-707035 in rat, dog and monkey (IV)[1].
| Rat | Monkey | Dog | |
| IV dose (mg/kg) | 0.87 | 1 | 1 |
| CL (ml/min/kg) | 9.7 | 6.8 | 2.0 |
| T1/2(h) | 4.0 | 6.5 | 6.0 |
| Vss(L/kg) | 0.86 | 0.87 | 0.45 |
| PO dose (mg/kg) | 4.4 | 5 | 5.2 |
| Cmax(μM) | 4.51 | 6.12 | 72.8 |
| tmax(h) | 0.25 | 0.25 | 0.25 |
| AUC (μM*h) | 19.1 | 19.2 | 162 |
| F (%) | 86 | 56 | 129 |
target
HIV-I integrase
BMS707035 Preparation Products And Raw materials
Raw materials
Preparation Products
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BMS707035 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
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