ChemicalBook > CAS DataBase List > ML 141

ML 141

Product Name
ML 141
CAS No.
71203-35-5
Chemical Name
ML 141
Synonyms
ML 141;CS-1743;CID-2950007;ML141;ML 141;ML 141 USP/EP/BP;ML141(CID-2950007);ML141;ML 141;CID-2950007;Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem;5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline;4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
CBNumber
CB72538281
Molecular Formula
C22H21N3O3S
Formula Weight
407.49
MOL File
71203-35-5.mol
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ML 141 Property

Melting point:
216 °C(Solv: ethanol (64-17-5))
Boiling point:
622.9±65.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL (warmed, clear solution)
form 
Yellow-white solid
pka
10.39±0.10(Predicted)
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0407
Product name
ML 141
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
217708
Product name
Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
Packaging
25mg
Price
$216
Updated
2024/03/01
Cayman Chemical
Product number
18496
Product name
ML 141
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18496
Product name
ML 141
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0407
Product name
ML 141
Purity
≥98% (HPLC)
Packaging
25mg
Price
$505
Updated
2024/03/01
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ML 141 Chemical Properties,Usage,Production

Uses

ML 141 has been used:

  • to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
  • as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
  • as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
  • as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells

Definition

ChEBI: 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide is a sulfonamide.

Biochem/physiol Actions

ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking.

storage

Store at +4°C

ML 141 Preparation Products And Raw materials

Raw materials

Preparation Products

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71203-35-5, ML 141Related Search:

9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- Nodinitib-1 ML385 ML365 ML355 M348 ml390 (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML277 ML364 VU0456810 ML-327 IKK 16 Pictilisib NSC 23766 (hydrochloride) Entinostat EHT1864

  • 4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide
  • CID-2950007
  • 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141
  • 4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
  • ML 141
  • 5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline
  • ML141;ML 141
  • 4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
  • 4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
  • CS-1743
  • ML141(CID-2950007)
  • ML141;ML 141;CID-2950007
  • Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
  • 4-[2-(1-PIPERIDINYL)ETHYL]-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZI<WBR />NE TRIHYDROCHLORIDE
  • Benzenesulfonamide, 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-
  • ML 141 USP/EP/BP
  • 71203-35-5
  • Inhibitors
  • API