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Cibenzoline succinate

Product Name
Cibenzoline succinate
CAS No.
100678-32-8
Chemical Name
Cibenzoline succinate
Synonyms
ritmalan;ole(1:1);cipralan;Cinobezile;ro22-7796/001;Cibenzoline succinate;cibenzolinesuccinate(1:1);(+-)-2-(2,2-diphenylcyclopropyl)-2-imidazolinesuccinate(1:1);4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolsuccinate;4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolesuccinate
CBNumber
CB7255168
Molecular Formula
C18H18N2.C4H6O4
Formula Weight
380.44
MOL File
100678-32-8.mol
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Cibenzoline succinate Property

Melting point:
165°
storage temp. 
2-8°C
solubility 
H2O: ≥5mg/mL
form 
solid
color 
white to off-white
Water Solubility 
H2O: ≥5mg/mL
Stability:
Light Sensitive
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
EJ9960100
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1618
Product name
Cibenzoline succinate
Purity
≥97% (NMR), solid
Packaging
10mg
Price
$192
Updated
2024/03/01
Sigma-Aldrich
Product number
C1618
Product name
Cibenzoline succinate
Purity
≥97% (NMR), solid
Packaging
50mg
Price
$605
Updated
2024/03/01
TRC
Product number
C535725
Product name
Cibenzoline succinate
Packaging
5mg
Price
$115
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002004
Product name
CIBENOL
Purity
95.00%
Packaging
10MG
Price
$675.51
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002004
Product name
CIBENOL
Purity
95.00%
Packaging
50MG
Price
$1069.65
Updated
2021/12/16
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Cibenzoline succinate Chemical Properties,Usage,Production

Uses

Cardiac depressant (anti-arrhythmic).

Uses

Cibenzoline Succinate acts as a highly active class I antiarrhythmic agent.

Definition

ChEBI: Cibenzoline succinate is a diarylmethane.

General Description

Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(?) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.

Biochem/physiol Actions

Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.

Cibenzoline succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Cibenzoline succinate Suppliers

China 13 Germany 3 India 1 Italy 1 Switzerland 1 United Kingdom 2 United States 10 Global 31
Mitsubishi Chemical Europe GmbH
Tel
--
Fax
--
Email
info@mc-e.de
Country
Germany
ProdList
1250
Advantage
58
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
Archimica
Tel
--
Fax
--
Email
juergen.brockmann@clariant.com
Country
Germany
ProdList
526
Advantage
68

100678-32-8, Cibenzoline succinateRelated Search:

Cefazolin Dioctyl sulfosuccinate sodium salt 6alpha-Methylprednisolone sodium succinate Cefazolin sodium salt Tolazoline hydrochloride Dichlorodiphenylsilane Metroprolol succinate Succinic acid iron succinate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Disodium succinate Chlorodiphenylphosphine Imidazole Oxymetazoline hydrochloride BUTYRAMIDINE Cibenzoline Cibenzoline succinate 4-methylpentanimidamide

  • (+-)-2-(2,2-diphenylcyclopropyl)-2-imidazolinesuccinate(1:1)
  • ole(1:1)
  • ritmalan
  • ro22-7796/001
  • succinic acid, compound with 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole (1:2)
  • 2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate
  • 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate, Cibenol, Cipralan, Exacor
  • Cinobezile
  • Cibenzoline succinate
  • 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazol(+-)-1h-imidazolbutanedioate(
  • 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolesuccinate
  • 4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1h-imidazolsuccinate
  • butanedioicacid,compd.with2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidaz
  • butanedioicacid,compd.with2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1h-imidazole(1:1)
  • cibenzolinesuccinate(1:1)
  • cipralan
  • 100678-32-8
  • C18H18N2C4H6O4
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Voltage-gated Ion Channels
  • Potassium Channel Modulators
  • Ion Channels
  • Monovalent Ion Channels
  • Heterocyclic Compounds