ChemicalBook > CAS DataBase List > [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

Product Name
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
CAS No.
1000669-72-6
Chemical Name
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
Synonyms
CS-468;KW 2449;KW-2449 100MG;KW2449;KW 2449;KW-2449 ，S2158;KW-2449, 10 mM in DMSO;KW-2449;KW 2449; KW2449;KW-2449 hydrochloride HCL;[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
CBNumber
CB72554360
Molecular Formula
C20H20N4O
Formula Weight
332.4
MOL File
1000669-72-6.mol
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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Property

Boiling point:
604.1±55.0 °C(Predicted)
Density 
1.28
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
pka
13.76±0.40(Predicted)
form 
solid
color 
Pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22207
Product name
KW 2449
Purity
≥98%
Packaging
5mg
Price
$35
Updated
2024/03/01
Cayman Chemical
Product number
22207
Product name
KW 2449
Purity
≥98%
Packaging
10mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
22207
Product name
KW 2449
Purity
≥98%
Packaging
25mg
Price
$149
Updated
2024/03/01
Cayman Chemical
Product number
22207
Product name
KW 2449
Purity
≥98%
Packaging
50mg
Price
$263
Updated
2024/03/01
AK Scientific
Product number
X7371
Product name
(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
Packaging
50mg
Price
$290
Updated
2021/12/16
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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties,Usage,Production

Description

KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3

Uses

KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.

Definition

ChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.

in vivo

Oral administration of KW-2449 shows dose-dependent and significant tumor growth inhibition in FLT3-mutated xenograft model with minimum bone marrow suppression. In FLT3 wild-type human leukemia, it induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis. In imatinib-resistant leukemia, KW-2449 contributes to release of the resistance by the simultaneous down-regulation of BCR/ABL and Aurora kinases. Furthermore, the antiproliferative activity of KW-2449 is confirmed in primary samples from AML and imatinib-resistant patients. The inhibitory activity of KW-2449 is not affected by the presence of human plasma protein, such as α1-acid glycoprotein[1].

target

FLT3

IC 50

Abl: 4 nM (IC50); ABL-T315I: 14 nM (IC50); FGFR1: 36 nM (IC50); Aurora A: 48 nM (IC50); FLT3/D835Y: 1 nM (IC50); FLT3: 6.6 nM (IC50); JAK2: 150 nM (IC50); SRC: 400 nM (IC50); PDFGRα: 1700 nM (IC50)

References

[1] Y. SHIOTSU. KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1 and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo .[J]. Blood, 2007, 110 1: 1832-1832. DOI:10.1182/blood.v110.11.1832.1832
[2] KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation
[3] KEITH W PRATZ. A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response.[J]. Blood, 2009, 113 17: 3938-3946. DOI:10.1182/blood-2008-09-177030

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Suppliers

China 119 France 1 India 1 United States 18 Global 139
Chembest Research Laboratories Limited
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+86-21-20908456
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Jinan Trio PharmaTech Co., Ltd.
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0531-88811783
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+86 (531) 55696010 QQ 1762738062
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Dalian Meilun Biotech Co., Ltd.
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Shanghai civi chemical technology co.,Ltd
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Shanghai Topbiochem Technology Co., Ltd
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NCE Biomedical Co.,Ltd.
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+86-27-87599188
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Haoyuan Chemexpress Co., Ltd.
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021-58950125
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(86) 21-58955996
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-6206333 13167063860
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021-50323701
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China
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Nanjing Dulai Biotechnology Co., Ltd.
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025-846993838003-8003 18013301590
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025-84699383-8003
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Nanjing Sunlida Biological Technology Co., Ltd.
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025-57019371
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View Lastest Price from [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone manufacturers

Career Henan Chemical Co
Product
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone 1000669-72-6
Price
US $2000.00-1950.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100kg
Release date
2018-08-04

1000669-72-6, [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanoneRelated Search:

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  • [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
  • KW 2449
  • (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
  • KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride
  • KW-2449;KW 2449; KW2449
  • [4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone
  • KW-2449 100MG
  • {4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone
  • 3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE
  • KW2449;KW 2449
  • CS-468
  • Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-
  • [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone USP/EP/BP
  • KW-2449 hydrochloride HCL
  • (4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
  • KW-2449, 10 mM in DMSO
  • KW-2449 ，S2158
  • 1000669-72-6
  • Inhibitors
  • Inhibitor