[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

Product Name: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
CAS No.: 1000669-72-6
Chemical Name: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
Synonyms: CS-468;KW 2449;KW-2449 100MG;KW2449;KW 2449;KW-2449;KW 2449; KW2449;KW-2449 hydrochloride HCL;[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone;Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-;3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE
CBNumber: CB72554360
Molecular Formula: C20H20N4O
Formula Weight: 332.4
MOL File: 1000669-72-6.mol

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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Property

Boiling point:: 604.1±55.0 °C(Predicted)
Density: 1.28
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
pka: 13.76±0.40(Predicted)
form: solid
color: Pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 5mg
Price: $35
Updated: 2024/03/01

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 10mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 25mg
Price: $149
Updated: 2024/03/01

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 50mg
Price: $263
Updated: 2024/03/01

AK Scientific

Product number: X7371
Product name: (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
Packaging: 50mg
Price: $290
Updated: 2021/12/16

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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties,Usage,Production

Description

KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3

Definition

ChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.

target

FLT3

References

Shiotsu et al. (2007) KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1, and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo; Blood; 110 1832 Shiotsu et al. (2009) KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation; Blood; 114 1607 Pratz et al. (2009) A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response; Blood; 113 3938

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Suppliers

China 86 France 1 India 1 United States 17 Global 105

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View Lastest Price from [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone manufacturers

Career Henan Chemical Co

Product: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone 1000669-72-6
Price: US $2000.00-1950.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100kg
Release date: 2018-08-04

1000669-72-6, [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanoneRelated Search:

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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

KW 2449

(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone

KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride

KW-2449;KW 2449; KW2449

[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone

KW-2449 100MG

{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone

3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE

KW2449;KW 2449

CS-468

Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone USP/EP/BP

KW-2449 hydrochloride HCL

1000669-72-6

Inhibitors

Inhibitor