2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
- Product Name
- 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
- CAS No.
- 1030825-20-7
- Chemical Name
- 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
- Synonyms
- 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene;)-5-(4-fL;Canogliflozin;Canagliflozin-19;CanagliflozinINT;Canagliflozin INT4;2-(5-Bromo-2-methyL;CAGLIFLOZIN IMPURITY C;Canagliflozin Bromo Imp;Kagliflozin impurity 24
- CBNumber
- CB72603549
- Molecular Formula
- C18H14BrFS
- Formula Weight
- 361.27
- MOL File
- 1030825-20-7.mol
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Property
- Melting point:
- 103 °C
- Boiling point:
- 438.3±40.0 °C(Predicted)
- Density
- 1.388
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
- InChIKey
- VLRIERSBZHUCOW-UHFFFAOYSA-N
- SMILES
- C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B5335
- Product name
- 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- B5335
- Product name
- 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $93
- Updated
- 2024/03/01
- Product number
- B685970
- Product name
- 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
- Packaging
- 100mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- PC448035
- Product name
- 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
- Purity
- 98%
- Packaging
- 5g
- Price
- $107
- Updated
- 2021/12/16
- Product number
- 5H66-B-00
- Product name
- 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
- Packaging
- 5G
- Price
- $172
- Updated
- 2021/12/16
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Chemical Properties,Usage,Production
Uses
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.
Synthesis
prepares 2-(4-fluorophenyl) thiophene III:
Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.
Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
1H NMR(500MHz,CDCl 3)δ7.65～7.54(m,2H),7.33～7.22(m,2H),7.14～7.03(m,3H).Gc-Ms:178.1.
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Preparation Products And Raw materials
Raw materials
Preparation Products
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Suppliers
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View Lastest Price from 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene manufacturers
- Product
- 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2024-01-02
- Product
- 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-13
- Product
- 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-22