ChemicalBook > CAS DataBase List > Mal-PEG6-COOH

Mal-PEG6-COOH

Product Name: Mal-PEG6-COOH
CAS No.: 1334177-79-5
Chemical Name: Mal-PEG6-COOH
Synonyms: Mal-PEG6-COOH;MAL dPEG6-acid;BMPA-PEG6-Acid;Mal-NH-PEG6-COOH;MALEIMIDE-NH-PEG6-;MAL-AMIDO-PEG6-COOH;Mal-amido-PEG6-acid;MAL-dPEG??-acid (QBD-10065);MaleiMide-NH-PEG6-CH2CH2COOH;Maleimide-PEG6-propionic acid
CBNumber: CB72603837
Molecular Formula: C22H36N2O11
Formula Weight: 504.53
MOL File: 1334177-79-5.mol

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Mal-PEG6-COOH Property

Boiling point:: 702.5±60.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 4.28±0.10(Predicted)
form: Solid
color: Off-white to gray
InChI: InChI=1S/C22H36N2O11/c25-19(3-6-24-20(26)1-2-21(24)27)23-5-8-31-10-12-33-14-16-35-18-17-34-15-13-32-11-9-30-7-4-22(28)29/h1-2H,3-18H2,(H,23,25)(H,28,29)
InChIKey: WKTGEZMXNNBFEZ-UHFFFAOYSA-N
SMILES: C(O)(=O)CCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M124985
Product name: Maleimide-NH-PEG6-CH2CH2COOH
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1474
Product name: Mal-amido-PEG6-acid
Packaging: 250mg
Price: $138
Updated: 2021/12/16

dPEG

Product number: 10065
Product name: MALdPEG®₆-acid
Packaging: 1000mg
Price: $150
Updated: 2021/12/16

BroadPharm

Product number: BP-22213
Product name: Mal-amido-PEG6-acid
Purity: 97%
Packaging: 100mg
Price: $190
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1474
Product name: Mal-amido-PEG6-acid
Packaging: 500mg
Price: $254
Updated: 2021/12/16

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Mal-PEG6-COOH Chemical Properties,Usage,Production

Description

Mal-amido-PEG6-acid is a PEG linker containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Uses

Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Mal-PEG6-COOH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mal-PEG6-COOH manufacturers

LAURENT

Product: Mal-NH-PEG6-CH2CH2COOH 1334177-79-5
Price: US $747.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-18

Xian confluore Biological Technology Co., Ltd.

Product: Mal-amido-PEG6-acid 1334177-79-5
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-27

1334177-79-5, Mal-PEG6-COOHRelated Search:

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MaleiMide-NH-PEG6-CH2CH2COOH

Mal-amido-PEG6-acid

Maleimide-PEG6-propionic acid

MAL-AMIDO-PEG6-COOH

Mal-NH-PEG6-COOH

Mal-PEG6-COOH

MALEIMIDE-NH-PEG6-

4,7,10,13,16,19-Hexaoxa-22-azapentacosanoic acid, 25-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-23-oxo-

Mal-amido-PEG6-propionic acid

MAL dPEG6-acid

1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22-hexaoxa-4-azapentacosan-25-oic acid

BMPA-PEG6-Acid

Mal-CH2CH2CONH-PEG6-CH2CH2COOH

MAL-dPEG??-acid (QBD-10065)

1334177-79-5

C22H36N2O11

Heterobifunctional PEG

peg