1-(1-Benzothiophen-4-yl)piperazine hydrochloride

Product Name: 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
CAS No.: 913614-18-3
Chemical Name: 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
Synonyms: 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride;1-Benzo[b]thien-4-yl-piperazine hydrochloride;7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one;1-Benzo[b]thien-4-ylpiperazine Monohydrochloride;1-benzo[b]thien-4-yl-;Brexpiprazole intermediate;Brexpiprazole Intermediate 2;Brexpiprazole Impurity 9 HCl;Brexpiprazole Impurity 32 HCl;1-Benzo[b]thien-4-yl-piperazinel HCl
CBNumber: CB72662777
Molecular Formula: C12H15ClN2S
Formula Weight: 254.7789
MOL File: 913614-18-3.mol

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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Property

Melting point:: >250°C (dec.)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Very Slightly)
form: Solid
color: White

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TRC

Product number: B194840
Product name: 1-Benzo[b]thien-4-yl-piperazineMonohydrochloride
Packaging: 5g
Price: $250
Updated: 2021/12/16

SynQuest Laboratories

Product number: 7H66-5-65
Product name: 1-(1-Benzothiophen-4-yl)piperazinehydrochloride
Packaging: 250mg
Price: $175
Updated: 2021/12/16

Apolloscientific

Product number: OR305616
Product name: 1-(1-Benzothiophen-4-yl)piperazinehydrochloride
Packaging: 25g
Price: $244
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139272
Product name: 1-Benzo[b]thien-4-ylpiperazine monohydrochloride
Packaging: 25g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: OR305616
Product name: 1-(1-Benzothiophen-4-yl)piperazinehydrochloride
Packaging: 5g
Price: $116
Updated: 2021/12/16

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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Chemical Properties,Usage,Production

Uses

4-Piperazinylbenzothiophene hydrochloride is the raw material for preparing piperazine-substituted benzothiophene, which can be used for the treatment and prevention of mental diseases including central nervous system diseases.

Synthesis

Synthesis of 4-(1-piperazinyl)benzo[b]thiophene hydrochloride 4-Chlorobenzo[b]thiophene (5.00 g), piperazine (5.11 g), palladium acetate (II) (2.7 mg), tri-tert-butylphosphonium tetraphenylborate (6.2 mg), sodium tert-butoxide (8.548 g), and xylene (70 ml) were stirred at 120 to 130°C for 5 hours. After the reaction mixture was cooled to room temperature, water was added thereto, and the layers were separated. The xylene layer was washed with water, and then with saline. After addition of activated carbon, the mixture was stirred at room temperature for 30 minutes. After filtration of the mixture, concentrated hydrochloric acid was added to the filtrate, and the resulting mixture was stirred at room temperature for 30 minutes. The precipitated crystals were collected by filtration and dried to obtain compound. Yield: 6.94 g. 1H-NMR (DMSO-d6) δ ppm; 3.30 (4H, br.s), 3.61 (4H, br.s), 6.97 (1H, d, J = 7.8 Hz), 7.32 (1H, br. dd, J = 8.4, 7.8 Hz), 7.53 (1H, d, J = 5.6 Hz), 7.70 (1H, d, J = 8.4 Hz), 7.76 (1H, d, J = 5.6 Hz), 9.37 (1H, br.s).

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Suppliers

China 207 India 11 United Kingdom 2 United States 7 Global 227

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Sphinx Scientific Laboratory (Tianjin) Co., Ltd.

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View Lastest Price from 1-(1-Benzothiophen-4-yl)piperazine hydrochloride manufacturers

Jinan Finer Chemical Co., Ltd

Product: 1-Benzo[b]thien-4-ylpiperazine monohydrochloride 913614-18-3
Price: US $0.00/Kg/Drum
Min. Order: 10g
Purity: 99%
Supply Ability: 100mt/year
Release date: 2021-06-23

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: 1-(1-Benzothiophen-4-yl)piperazine hydrochloride 913614-18-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-29

Henan Fengda Chemical Co., Ltd

Product: 1-(1-Benzothiophen-4-yl)piperazine hydrochloride 913614-18-3
Price: US $35.00-0.90/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-22

913614-18-3, 1-(1-Benzothiophen-4-yl)piperazine hydrochlorideRelated Search:

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913614-18-3