X-376

ChemicalBook > CAS DataBase List > X-376

Product Name: X-376
CAS No.: 1365267-27-1
Chemical Name: X-376
Synonyms: X-396;X-376;CS-1720;Ensartinib;Ensartinib (X-376);(R)-6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide;6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide;6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide;3-Pyridazinecarboxamide, 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-
CBNumber: CB72667853
Molecular Formula: C25H25Cl2FN6O3
Formula Weight: 547.41
MOL File: 1365267-27-1.mol

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X-376 Property

Boiling point:: 695.1±55.0 °C(Predicted)
Density: 1.428±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Ethanol:13.0(Max Conc. mg/mL);23.75(Max Conc. mM)
form: A crystalline solid
pka: 10.70±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21341
Product name: Ensartinib
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21341
Product name: Ensartinib
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21341
Product name: Ensartinib
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 21341
Product name: Ensartinib
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-6077
Product name: X-376
Purity: 98.36%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

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X-376 Chemical Properties,Usage,Production

Uses

X-376 is an ALK inhibitor with potential efficacy in the treatment of non-small cell lung cancer.

Side effects

The more common side effects of X-376 treatment include rash, itching, edema, and anemia.

Physiological effects

Ensatinib (X-376) is a second-generation tyrosine kinase inhibitor (TKI) small-molecule targeted drug targeting ALK fusion, which can selectively bind to the products of two driver gene mutations, ALK and MET. Block the activation and transmission of downstream signaling pathways, thereby inhibiting the growth and proliferation of cancer cells with these mutations, and exerting anti-cancer effects.

X-376 Preparation Products And Raw materials

Raw materials

Preparation Products

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1365267-27-1, X-376Related Search:

AZD-6244 ARRY-334543 Dovitinib Volitinib Erlotinib Sunitinib SU 6668 3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione INCB39110 Filgotinib Decernotinib Masitinib Lestaurtinib CAL-101 PLX3397 (Pexidartinib) CO-1686 Momelotinib 790299-79-5

X-376

X-396

6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide

Ensartinib

(R)-6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide

6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide

CS-1720

3-Pyridazinecarboxamide, 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-

Ensartinib (X-376)

1365267-27-1

C25H25Cl2FN6O3