N-(2-Aminoethyl)piperidine Property

Melting point:

67-70 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2))

Boiling point:

186 °C(lit.)

Density 

0.899 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.473(lit.)

Flash point:

136 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

Liquid

pka

pK1: 6.38;pK2: 9.89 (30°C)

color 

Clear colorless to yellow

Water Solubility 

Partly miscible in water.

Sensitive 

Air Sensitive

BRN 

103469

CAS DataBase Reference

27578-60-5(CAS DataBase Reference)

NIST Chemistry Reference

1-Piperidineethanamine(27578-60-5)

Safety

Hazard Codes 

C,Xi

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2734 8/PG 2

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

3

PackingGroup 

III

HS Code 

29333990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

N-(2-Aminoethyl)piperidine Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO YELLOW LIQUID

Uses

1-(2-Aminoethyl)piperidine is used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead and in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel. It is also used as a reactant for synthesis of: analogs of anticancer agents, inhibitor of botulinum neurotoxin serotype A light chain, P. falciparum malaria, and Ebola filovirus, cannabinoid CB1 receptor antagonists, small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, potent and selective 5-HT6 antagonists and N-mustards as anticancer agents. 1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.

General Description

1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.