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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide

Product Name
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
CAS No.
16673-34-0
Chemical Name
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
Synonyms
5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide;NLRP3i;NLRP3-IN-2;Einecs 240-722-5;16673-34-0 NLRP3i;Glyburide USP RC A;Glibenclamide Impurity 7;Glibenclamide EP Impurity A;Glyburide Related CoMpound A;NLRP3 Inflammasome InhibitorⅠ
CBNumber
CB7278059
Molecular Formula
C16H17ClN2O4S
Formula Weight
368.84
MOL File
16673-34-0.mol
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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Property

Melting point:
209-214 °C
Density 
1.356±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 45 mg/ml).
pka
10.14±0.10(Predicted)
form 
Solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI
InChI=1S/C16H17ClN2O4S/c1-23-15-7-4-12(17)10-14(15)16(20)19-9-8-11-2-5-13(6-3-11)24(18,21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H2,18,21,22)
InChIKey
KVWWTCSJLGHLRM-UHFFFAOYSA-N
SMILES
C(NCCC1=CC=C(S(N)(=O)=O)C=C1)(=O)C1=CC(Cl)=CC=C1OC
CAS DataBase Reference
16673-34-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
23-24-25
Safety Statements 
24/25
WGK Germany 
1
HS Code 
2935909550
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2414
Product name
Glyburide Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
50MG
Price
$534
Updated
2024/03/01
Sigma-Aldrich
Product number
BP071
Product name
4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonamide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
25MG
Price
$266
Updated
2024/03/01
Sigma-Aldrich
Product number
463442
Product name
5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
Purity
95%
Packaging
5g
Price
$66
Updated
2024/03/01
Sigma-Aldrich
Product number
1295516
Product name
Glyburide Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1490
Updated
2024/03/01
Cayman Chemical
Product number
30895
Product name
NLRP3i
Packaging
1g
Price
$62
Updated
2024/03/01
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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Chemical Properties,Usage,Production

Description

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising?in vivo?protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2?Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2

Chemical Properties

Light Yellow Solid

Uses

An impurity arising in the synthesis of Glyburide (G598350).

General Description

5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide is an organic building block. It has been reported as an intermediate in the synthesis of glyburide. Synthesis of 5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide has been reported.

storage

Store at +4°C

References

1) Fulp?et al.?(2018),?Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem.,?61?5412 2) Marchetti?et al.?(2014),?A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol.,?63?316

4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Preparation Products And Raw materials

Raw materials

5-CHLORO-2-METHOXYBENZOYL CHLORIDE 2-METHOXYBENZAMIDE 5-Chloro-2-hydroxybenzoic acid Thionyl chloride 5-Chloro-2-methoxybenzoic acid Dimethyl sulfate

Preparation Products

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4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide Suppliers

Canada 2 China 139 Germany 1 India 16 Japan 1 Slovakia 1 South Korea 1 Switzerland 1 United Kingdom 11 United States 26 Global 199
SIGMA-RBI
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide manufacturers

Career Henan Chemical Co
Product
4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide 16673-34-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1000kg
Release date
2019-06-26

16673-34-0, 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamideRelated Search:

Ethyl pyruvate P-AMINOBENZAMIDE GLUTAMIC ACID 2-(2-Aminoethylamino)ethanol Ethylparaben Ethyl acetate Ethyl formate Ethyl cyanoacetate Ethanol Ethyl acrylate Sulfanilamide Benzamide Diphenyl ether ISOXADIFEN-ETHYL PHENYL VALERATE PHENYL RESIN Phenylacetic acid Difluorochloromethane Glibenclamide

  • 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide
  • Glyburide Related Compound A (25 mg) (5-chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide)
  • 4-[2-(2-Methoxy-5-chlorobenzene-1-carboxaMido)ethyl]benzenesulfonaMide
  • 5-Chloro-N-(p-sulfaMoylphenethyl)-o-anisaMide
  • 5-Chloro-2-Methoxy-N-(4-sulfaMoylphenethyl)benzaMide
  • GlibenclaMide (Glyburide) IMpurity A
  • Glyburide Related CoMpound A
  • Glyburide Related Compound A (25 mg) (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide)
  • Glyburide USP RC A
  • 5-Chloro-2- methoxy-N-[2-(4-sulphamoylphenyl
  • 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95%
  • NLRP3 Inflammasome Inhibitor I
  • NLRP3 Inflammasome InhibitorⅠ
  • 5-chloro-2-methoxy-n-(2-(4-sulfamoyl-phenyl)ethyl
  • Glibenclamide Impurity 1(Glibenclamide EP Impurity A)
  • NLRP3i
  • N-(2-(4-(Aminosulfonyl)phenyl)ethyl)-5-chloro-2-methoxybenzamide
  • 4-(5-CHLORO-2-METHOXYBENZAMIDOETHYL)BENZENESULFONAMIDE
  • 4-[2-(5-CHLORO-2-METHOXY-BENZAMIDE)ETHYL]-BENZENESULPHONAMIDE
  • 4-(2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL)PHENYLSULFONAMIDE
  • 4-[2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL]PHENYLSULPHONAMIDE
  • 4-[2-(2-METHOXY-5-CHLOROBENZAMIDO)ETHYL]BENZENESULFONAMIDE
  • 5-CHLORO-2-METHOXY-N-[2-(P-SULFAMOYLPHENYL)ETHYL]BENZAMIDE
  • 5-CHLORO-2-METHOXY-N-[2-(4-SULFAMOYLPHENYL)ETHYL]BENZAMIDE
  • N-(2-(4-sulfamoyl)phenyl)ethyl-5-chloro-2-methoxybenzamide
  • N-[2-[4-(aminosulphonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
  • 4-[2-(2-Methoxy-5-Chloro Benzamido)Ethyl]Sulphonamide
  • [2-(5-Chloro-2.methoxybenzamido)-ethyl]-phenylsulfonamide
  • 4-Ethyl-3-(2-methoxy-5-chlorbenzamido)-benzolsulfonamid
  • 4-2-(5-CHLORO-2-METHOXYBENZAMIDO)-ETHYL BENZENSULFONAMIDE
  • BENZAMIDE, N-[2-[4-(AMINOSULFONYL) PHENYL]ETHYL]-5-CHLORO-2-METHOXY (GLYBIN SULFONAMIDE)
  • Einecs 240-722-5
  • N-[4-(Aminosulfonyl)phenethyl]-2-methoxy-5-chlorobenzamide
  • Glyburide USP Related Compound A
  • Glibenclamide (Glyburide) EP Impurity A
  • Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
  • 5-chloro-2-methoxy-N-[2-(4-sulphamoylphenyl)ethyl]benzamide
  • Glibenclamide EP Impurity A
  • 5-Chloro-2-methoxy-N-[2-(4-sulfamoy
  • 16673-34-0 NLRP3i
  • Benzamide, N-[2-[4-(aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxy-
  • NLRP3-IN-2
  • 4-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfamide ISO 9001：2015 REACH
  • Glibenclamide EP Impurity A/ Glyburide Related Compound A
  • Glibenclamide EP Impurity AQ: What is Glibenclamide EP Impurity A Q: What is the CAS Number of Glibenclamide EP Impurity A Q: What is the storage condition of Glibenclamide EP Impurity A Q: What are the applications of Glibenclamide EP Impurity A
  • Glibenclamide ImpurityⅠ:5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
  • Glyburide Related Compound A (4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide) (1295516)
  • Glibenclamide Impurity 7
  • Sulphonamide of Glibenclamide
  • Glibenclamide (Glyburide) EP Impurity A (Glibenclamide (Glyburide) USP Related Compound A)
  • 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide|||NLRP3 Inflammasome Inhibitor I
  • Glibenclamide Impurity Ⅰ(4-[2-(5-chloro-2-methoxybenzamido)ethyl]benzenesulfonamide)
  • 16673-34-0
  • C16H17ClN2O4S
  • ClC6H3OCH3CONHCH2C6H4SO2NH2
  • C16H17N2O4ClS
  • 36884
  • Sulfur Compounds