2,5-Dibromopyridine

ChemicalBook > CAS DataBase List > 2,5-Dibromopyridine

2,5-Dibromopyridine

Product Name: 2,5-Dibromopyridine
CAS No.: 624-28-2
Chemical Name: 2,5-Dibromopyridine
Synonyms: Dibromopyridine;NSC 76597;5-DibroMopyridine;2,5-Dibrompyridin;2,5-dibromopyridin;2,5 dibromopyrdine;2,5-DIBROMOPYRIDINE;3,6-DibroMopyridine;2,5 Di bromo pyridne;Perampanel Impurity 9
CBNumber: CB7283491
Molecular Formula: C5H3Br2N
Formula Weight: 236.89
MOL File: 624-28-2.mol

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2,5-Dibromopyridine Property

Melting point:: 92-95 °C (lit.)
Boiling point:: 235 °C / 772mmHg
Density: 2.0383 (rough estimate)
refractive index: 1.5800 (estimate)
Flash point:: 62℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: -1.57±0.10(Predicted)
form: Crystalline Powder
color: Almost white or light beige to brown
Water Solubility: insoluble
BRN: 109099
InChI: InChI=1S/C5H3Br2N/c6-4-1-2-5(7)8-3-4/h1-3H
InChIKey: ZHXUWDPHUQHFOV-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(Br)C=C1
CAS DataBase Reference: 624-28-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-36/37/39-36
RIDADR: UN2811
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D43107
Product name: 2,5-Dibromopyridine
Purity: 98%
Packaging: 10g
Price: $96.9
Updated: 2024/03/01

TCI Chemical

Product number: D1217
Product name: 2,5-Dibromopyridine
Purity: >99.0%(GC)
Packaging: 5g
Price: $24
Updated: 2024/03/01

TCI Chemical

Product number: D1217
Product name: 2,5-Dibromopyridine
Purity: >99.0%(GC)
Packaging: 25g
Price: $66
Updated: 2024/03/01

Alfa Aesar

Product number: A10937
Product name: 2,5-Dibromopyridine, 97%
Packaging: 10g
Price: $70.65
Updated: 2024/03/01

Alfa Aesar

Product number: A10937
Product name: 2,5-Dibromopyridine, 97%
Packaging: 50g
Price: $257.65
Updated: 2024/03/01

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2,5-Dibromopyridine Chemical Properties,Usage,Production

Description

Pyridine and its derivatives are distributed widely by nature. Many plant constituents are as contain pyridine ring compounds in the structure of alkaloids, etc.; they are the bases producing many vital compounds and are indispensable raw materials during medicine, agricultural chemicals, dyestuff, tension-active agents, rubber ingredients, fodder additives, foodstuff additives, tackiness agents, etc. are produced.2,5-dibromo pyridine is an important intermediate of organic synthesis and is mainly used in medicine intermediate, organic synthesis, and organic solvent, can also be applicable to aspects such as DYE PRODUCTION, pesticide production and spices. Selective monolithiation of 2,5-dibromopyridine at either the 2-position or the 5-position is reported. Solvent and concentration strongly influence the selectivity. Coordinating solvents and higher concentration favour the 5-position, while non-coordinating solvents and lower concentration favour the 2-position[1].

Chemical Properties

2,5-Dibromopyridine is an off-white crystalline solid. It is insoluble in water but soluble in strong polar organic solvents. It exhibits strong alkalinity.

Uses

2,5-Dibromopyridine (cas# 624-28-2) is a compound useful in organic synthesis.

Preparation

To synthesize 2,5-dibromopyridine, follow these steps:
Add 2-amino-5-bromopyridine (13.0 kg) into a water-cooled solution at 10 °C.
Slowly add 47% aqueous hydrogen bromide (37 L) to the mixture.
Introduce liquid bromine (11 L) into the mixture.
Maintain the reaction temperature below 10 °C.
Prepare a solution of NaNO2 (16.1 kg) and H2O (19 L) and add it dropwise to the mixture while keeping the temperature between 0-5 °C.
Stir the reaction mixture for 30 minutes.
Treat the mixture with a solution of NaOH (28.0 kg) in water (30 L) at a controlled rate below 20-25 °C.
Extract the reaction mixture with diethyl ether (3 × 40 L).
Dry the organic layer with anhydrous Na2SO4.
Remove the desiccant by filtration.
Evaporate the resulting filtrate under reduced pressure to dryness.
Suspend the residue in heptane (10 L).
Collect the target product molecule, 2,5-dibromopyridine, by filtration.
Synthesis method of 2,5-dibromopyridine

References

[1] Xin Wang. “Selective monolithiation of 2,5-dibromopyridine with butyllithium.” Tetrahedron Letters 41 1 (2000): 4335–4338.

2,5-Dibromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-Bromo-5-iodopyridine 5-Bromo-2-pyridinecarboxylic Acid 5-BROMOPYRIDINE-2-CARBONYL CHLORIDE 6-Methoxynicotinaldehyde 2-(5-BROMO-2-PYRIDYLAZO)-5-(DIETHYLAMINO)PHENOL 2-Bromopyridine-5-boronic acid 5-(Trifluoromethyl)pyridine-2-carboxylic acid 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIDINE 6-(1-PYRROLIDINYL)NICOTINALDEHYDE 5-Bromo-3-pyridinecarboxaldehyde 2-Trifluoromethyl-5-bromopyridine

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View Lastest Price from 2,5-Dibromopyridine manufacturers

Hebei Mujin Biotechnology Co.,Ltd

Product: 2,5-Dibromopyridine 624-28-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-12

Watson Biotechnology Co.,Ltd

Product: 2,5-Dibromopyridine 624-28-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20MT
Release date: 2024-08-02

Shanghai UCHEM Inc.

Product: 2,5-Dibromopyridine 624-28-2
Price: US $136.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100kg
Release date: 2023-11-17

624-28-2, 2,5-DibromopyridineRelated Search:

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2,5-DIBROMOPYRIDINE

PYRIDINE, 2,5-DIBROMO-

Dibromopyridine

2,5-Dibromopyridine, 97+%

2,5-dibromopyridin

2,5-DIBROMOPYRIDINE 2,5-DIBROMOPYRIDINE

2,5-Dibromo pyridine ,98%

2,5-DibroMopyridine, 97% 10GR

3,6-DibroMopyridine

NSC 76597

5-DibroMopyridine

2, 5-2 broMide pyridine

2,5 Di bromo pyridne

2,5-Dibromopyridine &gt

Perampanel Impurity 9

2,5-Dibromopyridine ISO 9001：2015 REACH

2,5-Dibrompyridin

2,5 dibromopyrdine

Hot Sale?2, 5-Dibromopyridine CAS?624-28-2?with Best Price

Pyronoprene Impurity 17

Nicotinic Acid Impurity 13

624-28-2

324-28-2

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Bromopyridines

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alkyl bromide

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bc0001

624-28-2