2,5-Dibromopyridine
- Product Name
- 2,5-Dibromopyridine
- CAS No.
- 624-28-2
- Chemical Name
- 2,5-Dibromopyridine
- Synonyms
- Dibromopyridine;NSC 76597;5-DibroMopyridine;2,5-Dibrompyridin;2,5-dibromopyridin;2,5 dibromopyrdine;2,5-DIBROMOPYRIDINE;3,6-DibroMopyridine;2,5 Di bromo pyridne;Perampanel Impurity 9
- CBNumber
- CB7283491
- Molecular Formula
- C5H3Br2N
- Formula Weight
- 236.89
- MOL File
- 624-28-2.mol
2,5-Dibromopyridine Property
- Melting point:
- 92-95 °C (lit.)
- Boiling point:
- 235 °C / 772mmHg
- Density
- 2.0383 (rough estimate)
- refractive index
- 1.5800 (estimate)
- Flash point:
- 62℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- -1.57±0.10(Predicted)
- form
- Crystalline Powder
- color
- Almost white or light beige to brown
- Water Solubility
- insoluble
- BRN
- 109099
- InChI
- InChI=1S/C5H3Br2N/c6-4-1-2-5(7)8-3-4/h1-3H
- InChIKey
- ZHXUWDPHUQHFOV-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(Br)C=C1
- CAS DataBase Reference
- 624-28-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-36
- RIDADR
- UN2811
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D43107
- Product name
- 2,5-Dibromopyridine
- Purity
- 98%
- Packaging
- 10g
- Price
- $96.9
- Updated
- 2024/03/01
- Product number
- D1217
- Product name
- 2,5-Dibromopyridine
- Purity
- >99.0%(GC)
- Packaging
- 5g
- Price
- $24
- Updated
- 2024/03/01
- Product number
- D1217
- Product name
- 2,5-Dibromopyridine
- Purity
- >99.0%(GC)
- Packaging
- 25g
- Price
- $66
- Updated
- 2024/03/01
- Product number
- A10937
- Product name
- 2,5-Dibromopyridine, 97%
- Packaging
- 10g
- Price
- $70.65
- Updated
- 2024/03/01
- Product number
- A10937
- Product name
- 2,5-Dibromopyridine, 97%
- Packaging
- 50g
- Price
- $257.65
- Updated
- 2024/03/01
2,5-Dibromopyridine Chemical Properties,Usage,Production
Description
Pyridine and its derivatives are distributed widely by nature. Many plant constituents are as contain pyridine ring compounds in the structure of alkaloids, etc.; they are the bases producing many vital compounds and are indispensable raw materials during medicine, agricultural chemicals, dyestuff, tension-active agents, rubber ingredients, fodder additives, foodstuff additives, tackiness agents, etc. are produced.2,5-dibromo pyridine is an important intermediate of organic synthesis and is mainly used in medicine intermediate, organic synthesis, and organic solvent, can also be applicable to aspects such as DYE PRODUCTION, pesticide production and spices. Selective monolithiation of 2,5-dibromopyridine at either the 2-position or the 5-position is reported. Solvent and concentration strongly influence the selectivity. Coordinating solvents and higher concentration favour the 5-position, while non-coordinating solvents and lower concentration favour the 2-position[1].
Chemical Properties
2,5-Dibromopyridine is an off-white crystalline solid. It is insoluble in water but soluble in strong polar organic solvents. It exhibits strong alkalinity.
Uses
2,5-Dibromopyridine (cas# 624-28-2) is a compound useful in organic synthesis.
Preparation
To synthesize 2,5-dibromopyridine, follow these steps:
Add 2-amino-5-bromopyridine (13.0 kg) into a water-cooled solution at 10 °C.
Slowly add 47% aqueous hydrogen bromide (37 L) to the mixture.
Introduce liquid bromine (11 L) into the mixture.
Maintain the reaction temperature below 10 °C.
Prepare a solution of NaNO2 (16.1 kg) and H2O (19 L) and add it dropwise to the mixture while keeping the temperature between 0-5 °C.
Stir the reaction mixture for 30 minutes.
Treat the mixture with a solution of NaOH (28.0 kg) in water (30 L) at a controlled rate below 20-25 °C.
Extract the reaction mixture with diethyl ether (3 × 40 L).
Dry the organic layer with anhydrous Na2SO4.
Remove the desiccant by filtration.
Evaporate the resulting filtrate under reduced pressure to dryness.
Suspend the residue in heptane (10 L).
Collect the target product molecule, 2,5-dibromopyridine, by filtration.
Synthesis method of 2,5-dibromopyridine
References
[1] Xin Wang. “Selective monolithiation of 2,5-dibromopyridine with butyllithium.” Tetrahedron Letters 41 1 (2000): 4335–4338.
2,5-Dibromopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dibromopyridine manufacturers
- Product
- 2,5-Dibromopyridine 624-28-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2024-08-02
- Product
- 2,5-Dibromopyridine 624-28-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-13
- Product
- 2,5-Dibromopyridine 624-28-2
- Price
- US $136.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100kg
- Release date
- 2023-11-17