Hazard and Precautionary Statements (GHS)

DL-CAMPHORIC ACID Chemical Properties,Usage,Production

Uses

DL-Camphoric acid is produced by oxidation of camphor and is widely used in the pharmaceutical and chemical industries. It can be used as an organic synthesis reagent. Camphoroquinone, endo-2-hydroxyepicamphor and endo-3-hydroxycamphor can be efficiently synthesized using camphoric acid as a raw material. In the pharmaceutical industry, camphoric acid is often used for local antipruritic, analgesic and anti-irritant effects. It acts on the skin and mucous membranes to control excessive secretions. It is particularly effective in treating night sweats (such as those caused by tuberculosis), but is also valuable for controlling the heavy sweating that occurs during recovery from prostration fever^[1].

Definition

ChEBI: (+/-)-Camphoric acid is a dicarboxylic acid.

Biological Activity

Camphoric acid is structurally similar to glutamate receptor ligands and significantly induces the expression of NMDAR1, GluR3/4, and mGluR8. However, it showed weak modulatory activity at glutamate receptors in radioligand binding assays. Camphoric acid also significantly induced the activation of NF-κB and AP-1^[1].

References

[1] SU-UI LEE. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression[J]. Amino Acids, 2008, 38 1: 85-93. DOI:10.1007/s00726-008-0208-5.