2-Chloro-4-hydroxypyridine
- Product Name
- 2-Chloro-4-hydroxypyridine
- CAS No.
- 17368-12-6
- Chemical Name
- 2-Chloro-4-hydroxypyridine
- Synonyms
- 2-CHLOROPYRIDIN-4-OL;12.15;2-CHLORO-4-PYRIDINOL;2-Chloro-4-hydroxypy;4-Pyridinol, 2-chloro-;Oliceridine Impurity 18;2-chloro-1H-pyridin-4-one;2-CHLORO-4-HYDROXYPYRIDINE;2-Chloro-4-hydroxylpyridine;2-Chloro-4-hydroxypyridine95%
- CBNumber
- CB7307520
- Molecular Formula
- C5H4ClNO
- Formula Weight
- 129.54
- MOL File
- 17368-12-6.mol
2-Chloro-4-hydroxypyridine Property
- Melting point:
- 169-172°C
- Boiling point:
- 401.8±25.0 °C(Predicted)
- Density
- 1.392±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 7.94±0.10(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C5H4ClNO/c6-5-3-4(8)1-2-7-5/h1-3H,(H,7,8)
- InChIKey
- VBEHFOMFHUQAOW-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(O)=C1
- CAS DataBase Reference
- 17368-12-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2516
- Product name
- 2-Chloro-4-hydroxypyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $18
- Updated
- 2025/07/31
- Product number
- C2516
- Product name
- 2-Chloro-4-hydroxypyridine
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- C585913
- Product name
- 2-Chloro-4-hydroxypyridine
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J53798
- Product name
- 2-Chloro-4-hydroxypyridine
- Packaging
- 25g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FC55412
- Product name
- 2-Chloro-4-hydroxypyridine
- Packaging
- 25g
- Price
- $90
- Updated
- 2021/12/16
2-Chloro-4-hydroxypyridine Chemical Properties,Usage,Production
Chemical Properties
White crystal
Uses
2-Chloro-4-hydroxypyridine is a chemical that is used as a building block for various organic synthesis reactions.
Preparation
2-Chloro-4-hydroxypyridine can be produced by the reaction of chloroform and pyridine, which results in the formation of 2-chloro-4-hydroxypyridine.
Reactions
2-Chloro-4-hydroxypyridine has been shown to react with copper metal under dehydrogenative conditions to form monochloropyridine. It also reacts with tribromide to form tribromopyridine and with graphene oxide to form hydroxypyridinium bromide. Lastly, it reacts with an organic solvent such as acet.
Synthesis
14432-12-3
17368-12-6
The general procedure for the synthesis of 2-chloro-4-hydroxypyridine from 2-chloro-4-aminopyridine is as follows: in a round-bottomed flask, 2-chloro-4-aminopyridine (3.0 g, 23.3 mmol) was dissolved in 40% sulfuric acid solution (50 g). The solution was stirred at 0 °C and sodium nitrite (1.93 g, 28.0 mmol) was added slowly. After addition, the reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the reaction solution was neutralized by dropwise addition of aqueous sodium hydroxide and aqueous sodium bicarbonate. Subsequently, the organic phase was extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered, distilled to remove the solvent and dried under reduced pressure to give 2-chloro-4-hydroxypyridine (light brown solid, 2.78 g, 92% yield). The product was characterized by 1H-NMR (270 MHz, DMSO-d6): δ 11.20 (s, 1H, -OH), 8.09 (d, 1H, J = 5.4 Hz, ArH), 6.81 (s, 1H, ArH), 6.77 (d, 1H, J = 2.2 Hz, ArH).
References
[1] Patent: WO2009/11447, 2009, A2. Location in patent: Page/Page column 37-38
2-Chloro-4-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-4-hydroxypyridine Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 2-Chloro-4-hydroxypyridine manufacturers
- Product
- 2-Chloro-4-hydroxypyridine 17368-12-6
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-06
- Product
- 2-Chloro-4-hydroxypyridine 17368-12-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 2-Chloro-4-hydroxypyridine 17368-12-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11