ChemicalBook > CAS DataBase List > Itopride hydrochloride

Itopride hydrochloride

Product Name
Itopride hydrochloride
CAS No.
122892-31-3
Chemical Name
Itopride hydrochloride
Synonyms
Itax;HC-803;Ganato;hsr803;Ganaton;ITOPRIDE HCL;ITOPRIDE HYDROCHLORIDE;ltopride Hydrochloride;Itopride Hydrochloride >Itopride Hydrochloride - API
CBNumber
CB7310786
Molecular Formula
C20H27ClN2O4
Formula Weight
394.89
MOL File
122892-31-3.mol
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Itopride hydrochloride Property

Melting point:
194-1950C
storage temp. 
2-8°C
solubility 
H2O: ≥48mg/mL
form 
powder
color 
white to tan
λmax
258nm(MeOH)(lit.)
Merck 
14,5244
CAS DataBase Reference
122892-31-3(CAS DataBase Reference)
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Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
RTECS 
CV4552000
HS Code 
2924.29.7790
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0033
Product name
Itopride hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$117
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0033
Product name
Itopride hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$275.4
Updated
2024/03/01
TCI Chemical
Product number
I0948
Product name
Itopride Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
I0948
Product name
Itopride Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$91
Updated
2024/03/01
TRC
Product number
I931500
Product name
Itopride Hydrochloride
Packaging
10mg
Price
$85
Updated
2021/12/16
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Itopride hydrochloride Chemical Properties,Usage,Production

Description

Itopride, a gastroprokinetic benzamide derivative was launched in Japan for the relief of gastrointestinal symptoms in patients with chronic gastritis. ltopride is a dopamine D2-receptor antagonist that stimulates acetylcholine (Ach) release on the postganglionic cholinergic neurons to cause Ach accumulation at muscarinic receptors and, therefore, enhances Ach-induced gastric contractions. In animal models, itopride was reported to increase GI transit and gastric emptying.

Chemical Properties

Crystalline Solid

Originator

Hokuriku (Japan)

Uses

Dopamine D2-receptor antagonist with anticholinesterase activity. Gastroprokinetic

Uses

Dopamine D2 receptor blockade,acetylcholinesterase inhibitor

Uses

Anti-Spasmodics

brand name

Ganaton

General Description

Itopride hydrochloride is a new prokinetic drug.

Biochem/physiol Actions

Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.

in vitro

itopride was found to inhibit both ache and horse serum butyrylcholinesterase (buche). the itopride ic50 against ache was, however, 100-fold less than that against buche. the recovery of ache activity inhibited by low dose of neostigmine was partial, but that inhibited by itopride was complete. double reciprocal plots showed that both vmax and km were affected by itopride, indicating a "mixed" type inhibition, although primarily being an uncompetitive one. in addition, the inhibitory effect of itopride on cholinesterase (che) activity in guinea pig gastrointestine was much weaker than that on pure ache [1].

in vivo

previoius animal study showed that in conscious dogs with implanted strain gauge force transducers, itopride could stimulate contractile activity in the gastrointestinal tract from stomach to colon. whereas, mosapride was able to stimulate contractile activity only in the gastric antrum and ileum. moreover, in rats s andguinea pig, itopride could accelerate colonic luminal transit, however, both mosapride and cisapride failed to enhance colonic transit. such findings suggested that itopride had a stimulatory action on propelling colonic luminal contents, colonic peristalsis, which was quite different from mosapride and cisapride [2].

IC 50

2.04 μm

References

[1] iwanaga y,kimura t,miyashita n,morikawa k,nagata o,itoh z,kondo y. characterization of acetylcholinesterase-inhibition by itopride. jpn j pharmacol.1994 nov;66(3):317-22.
[2] tsubouchi t,saito t,mizutani f,yamauchi t,iwanaga y. stimulatory action of itopride hydrochloride on colonic motor activity in vitro and in vivo. j pharmacol exp ther.2003 aug;306(2):787-93.

Itopride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Itopride hydrochloride manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Itopride hydrochloride 122892-31-3
Price
US $476.00/KG
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
1000KG
Release date
2021-06-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Itopride hydrochloride 122892-31-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min HPLC
Supply Ability
100KGS
Release date
2021-07-23
Hebei Weibang Biotechnology Co., Ltd
Product
Itopride Hydrochloride 122892-31-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10mt
Release date
2024-10-30

122892-31-3, Itopride hydrochlorideRelated Search:

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  • 122892-31-3
  • C20H27ClN2O4
  • C20H26N2O4HCl
  • C20H26N2O4ClH
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