BAY-1125976.

Product Name: BAY-1125976.
CAS No.: 1402608-02-9
Chemical Name: BAY-1125976.
Synonyms: CS-2913;BAY1125976;BAY 1125976;BAY-1125976.;BAY-1125976; BAY 1125976;inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976;2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide;Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
CBNumber: CB73133467
Molecular Formula: C23H21N5O
Formula Weight: 383.45
MOL File: 1402608-02-9.mol

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BAY-1125976. Property

storage temp.: Store at -20°C
solubility: DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28913
Product name: BAY-1125976
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 28913
Product name: BAY-1125976
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Cayman Chemical

Product number: 28913
Product name: BAY-1125976
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 28913
Product name: BAY-1125976
Packaging: 10mg
Price: $243
Updated: 2024/03/01

AK Scientific

Product number: 2002DU
Product name: 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide
Packaging: 5mg
Price: $252
Updated: 2021/12/16

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BAY-1125976. Chemical Properties,Usage,Production

Description

BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC₅₀s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC₅₀ = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC₅₀s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.

BAY-1125976. Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1125976. Suppliers

China 49 United States 5 Global 54

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

1402608-02-9, BAY-1125976.Related Search:

BAY1895344 2HCl BAY-2402234 BAY-885 BAY-985 BAY 1316957) BAY-1163877 BAY1895344 HCl BAY-1895344 Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl- BAY 2666605 BAY 2416964

2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide

BAY-1125976; BAY 1125976

CS-2913

BAY 1125976

BAY1125976

BAY-1125976.

Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-

inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976

1402608-02-9