ChemicalBook > CAS DataBase List > BAY-1125976.

BAY-1125976.

Product Name
BAY-1125976.
CAS No.
1402608-02-9
Chemical Name
BAY-1125976.
Synonyms
CS-2913;BAY1125976;BAY 1125976;BAY-1125976.;BAY-1125976; BAY 1125976;inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976;2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide;Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
CBNumber
CB73133467
Molecular Formula
C23H21N5O
Formula Weight
383.45
MOL File
1402608-02-9.mol
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BAY-1125976. Property

storage temp. 
Store at -20°C
solubility 
DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
10mg
Price
$243
Updated
2024/03/01
ChemScene
Product number
CS-6212
Product name
BAY1125976
Purity
99.86%
Packaging
2mg
Price
$132
Updated
2021/12/16
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BAY-1125976. Chemical Properties,Usage,Production

Description

BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC50s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC50 = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC50s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.

BAY-1125976. Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-1125976. Suppliers

China 55 United States 6 Global 61
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1402608-02-9, BAY-1125976.Related Search:

BAY1895344 2HCl BAY-2402234 BAY-885 BAY-985 BAY 1316957) BAY-1163877 BAY1895344 HCl BAY-1895344 Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl- BAY 2666605 BAY 2416964

  • 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide
  • BAY-1125976; BAY 1125976
  • CS-2913
  • BAY 1125976
  • BAY1125976
  • BAY-1125976.
  • Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
  • inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976
  • 1402608-02-9