Quinolinic acid

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Quinolinic acid

Product Name: Quinolinic acid
CAS No.: 89-00-9
Chemical Name: Quinolinic acid
Synonyms: PYRIDINE-2,3-DICARBOXYLIC ACID;2,3-PYRIDINEDICARBOXYLIC ACID;QUIN;2,3-Pyridinedicarboxylic;Pyridine-2,3-dicarboxylate;2,3-PyridinedicarboxylicAcid99%;109/KG;NSC 13127;NSC 18836;NSC 403247
CBNumber: CB7316162
Molecular Formula: C7H5NO4
Formula Weight: 167.12
MOL File: 89-00-9.mol

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Quinolinic acid Property

Melting point:: 188-190 °C (dec.) (lit.)
Boiling point:: 295.67°C (rough estimate)
Density: 1.5216 (rough estimate)
refractive index: 1.6280 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: 10g/l
pka: 2.43(at 25℃)
form: Crystalline Powder
color: White to light yellow-beige
Odor: odorless
Water Solubility: 0.55 g/100 mL
Merck: 14,8073
BRN: 137110
InChIKey: GJAWHXHKYYXBSV-UHFFFAOYSA-N
CAS DataBase Reference: 89-00-9(CAS DataBase Reference)
EPA Substance Registry System: 2,3-Pyridinedicarboxylic acid (89-00-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-33
Safety Statements: 26-36/37-24/25-37
WGK Germany: 3
RTECS: US7967250
TSCA: T
HazardClass: IRRITANT
HS Code: 29333999
Hazardous Substances Data: 89-00-9(Hazardous Substances Data)
Toxicity: Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P63204
Product name: 2,3-Pyridinedicarboxylic acid
Purity: 99%
Packaging: 25g
Price: $31.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: P63204
Product name: 2,3-Pyridinedicarboxylic acid
Purity: 99%
Packaging: 100g
Price: $34.8
Updated: 2024/03/01

TCI Chemical

Product number: P0550
Product name: 2,3-Pyridinedicarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $25
Updated: 2024/03/01

TCI Chemical

Product number: P0550
Product name: 2,3-Pyridinedicarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 500g
Price: $199
Updated: 2024/03/01

Alfa Aesar

Product number: A11414
Product name: Pyridine-2,3-dicarboxylic acid, 99%
Packaging: 25g
Price: $23.65
Updated: 2024/03/01

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Quinolinic acid Chemical Properties,Usage,Production

Chemical Properties

White powder;Light yellow powder

Uses

An inhibitor of glucose synthesis.

Uses

A matabolite of tryptophan and a putative NMDA receptor agonist.

Uses

Inhibits glucose synthesis

Uses

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an ?excitotoxic? metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Definition

ChEBI: Quinolinic acid is a pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. It has a role as a NMDA receptor agonist, a human metabolite, a mouse metabolite and an Escherichia coli metabolite. It is a conjugate acid of a quinolinate(1-) and a quinolinate.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3020, 1949 DOI: 10.1021/ja01177a021

Hazard

A poison by skin contact. Moderately toxic by ingestion. A mild skin irritant.

Industrial uses

The use of quinolinic acid during flotation of hematite results in the adsorption of quinoline on hematite, allowing amine to selectively adsorb onto the hematite surface.

Biological Activity

Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.

Safety Profile

A poison by skin contact. Moderately toxic by ingestion. Experimental reproductive effects. A mdd skinn irritant. When heated to decomposition it emits toxic vapors of NOx.

storage

Room temperature

Quinolinic acid Preparation Products And Raw materials

Raw materials

Diethyl oxalacetate Acrolein Quinoline Ethanol Dicarboxylic Acid Potassium permanganate

Preparation Products

3-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID METHYL 3-CYANOPYRIDINE-2-CARBOXYLATE 3-Amino-2-pyridinecarboxylic acid 5-Methylpyridine-2,3-dicarboxylic acid 3-CARBAMOYLPICOLINIC ACID 3-AMINO-6-BROMO-PYRIDIN-2-OL 5-Methoxymethyl-2,3-pyridinedicarboxylic acid 5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione METHYL 3-(CHLOROCARBONYL)PYRIDINE-2-CARBOXYLATE HYDROCHLORIDE 3-CYANOPYRIDINE-2-CARBOXYLIC ACID 2-(AMINOCARBONYL)NICOTINIC ACID 3-(METHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID

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View Lastest Price from Quinolinic acid manufacturers

Jinan Finer Chemical Co., Ltd

Product: Quinolinic acid 89-00-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 300mt
Release date: 2019-03-15

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Quinolinic acid 89-00-9
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200000kg
Release date: 2024-04-25

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Quinolinic Acid 89-00-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.6%
Supply Ability: 100000
Release date: 2024-04-24

89-00-9, Quinolinic acidRelated Search:

Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Ethoxyquin Pyridine Isoquinoline DIPIPERIDINOMETHANE OXALIC ACID Ethyl 2-(Chlorosulfonyl)acetate Chromium picolinate 2,6-Lutidine 5,6,7,8-TETRAHYDROISOQUINOLINE Folic acid Citric acid Glycine Ascoric Acid Quinclorac 2,5-PYRIDINEDICARBOXYLIC ACID 3,5-Pyridinedicarboxylic acid Pyridine-2,6-dicarboxylic acid

2,3-PyridinedicarboxylicAcid99%

QuinolinicAcid>99%

Pyridin-2,3-dicarbonsaeure

2,3-Pyridinedicarboxylic

2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID)

2,3-pyridine dicarbo

2,3-PYRIDINEDICARBOXYLIC ACID

AKOS BBS-00003814

AKOS AUF2085

PYRIDINE-2,3-DICARBOXYLI ACID

Quinolinic Acid 99%

2,3-Pyridinedicarboxylic acid, 99% 100GR

2,3-Pyridinedicarboxylic acid, 99% 25GR

NSC 13127

NSC 18836

NSC 403247

2,3-PYRIDINEDICARBOXYLIC ACID FOR SYNTHE

Pyridinecarboxylic acid-2,3- two

2,3-Pyridinedicarboxylic acid 99%

2,3-PYRIDINEDICARBOXYLIC ACID AKOS AUF2085

2,3-pyridinediacrboxylic acid

Pyridine-2,3-dicarboxylic acid (quinolinic acid)

109/KG

2,3-Pyridinedicarboxylic acid Vetec(TM) reagent grade, 98%

RARECHEM AL BO 0810

QUINOLIC ACID

QUINOLINIC ACID

PYRIDINE-2,3-DICARBOXYLIC ACID

2,3 PYRIDINE DICARBOXYLIC ACID (AS PER INVOICE AND PACKING LIST)

Pyridine-2,3-dicarboxylate

2,3-PyridinedicarboxylicAcid&gt

QUIN

Pyridine-2,3-Dicarboxylic Acid,99%,

2,3-PyridinedicarboxyL

Quinolinic acid (2,3-pyridinedihydroxy acid)

Pyridine Dicarbonylic Acid

89-00-9

98-00-9

Building Blocks

C7 and C8

CARBOXYLIC ACID

Pyridines

Quinolines

Heterocyclic Building Blocks

Pyridine series

Pyridine

pyridine derivative

Carboxylic Acids

Pyridines

Heterocyclic Compounds

Heterocycles

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Carboxylic Acids

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